Medical Xpress: Commercial #tea bags release millions of #microplastics, entering human #intestinal cells
https://medicalxpress.com/news/2024-12-commercial-tea-bags-millions-microplastics.html

Both proteins & mRNAs have global basal-apical polarization in mouse #intestinal epithelium. Study of human intestinal cells by @SItzkovitz &co shows that while mRNAs are similarly polarized, human #mitochondria & #ribosomes are less polarized #PLOSBiology https://plos.io/3OGRZ1M

@Infoseepage Here another proof of what you're saying: #Pathogenesis of #H5N1 #Influenza Virus Infections in #Mice & #Ferret Models Differs According to #Respiratory Tract or #Digestive System Exposure, J Infect Dis.: https://academic.oup.com/jid/article/199/5/717/902376?login=false

Our results demonstrated that exposure of digestive system to H5N1 influenza viruses could initiate infection either through the #tonsil, with spread to respiratory tissues, or through #intestinal infection, with spread to the liver and #pancreas.

The findings showed that consuming #natto induced changes in the #intestinal #microflora, suppressing #inflammation and preventing #arteriosclerosis.
#NutritionalScience #Medical #Health #sflorg
https://www.sflorg.com/2023/12/nut12202301.html

Clostridioides difficile (C. diff) #intestinal #infections can cause severe, debilitating #diarrhea in patients who are hospitalized or on #immunosuppressive therapies. The infections can be very hard to eradicate
#Microbiology #Medical #sflorg
https://www.sflorg.com/2023/10/mcb10262301.html

The gut #microbiome—the population and variety of #bacteria within the intestine—is thought to influence a number of #behavioral and #disease traits in humans. Most obviously, it affects #intestinal health. #Cancer, inflammatory bowel disease, and #celiac disease
#Microbiology #Chemistry #Engineering #Biology #sflorg
https://www.sflorg.com/2023/10/mcb10142301.html

• #Mitochondrial dysfunction of #intestinal epithelial cells leads to gut #microbiota dysbiosis.
• #Mitochondria of intestinal epithelial cells may be a newly-found important factor in the pathogenesis of depression.
• Protection of the mitochondrial function of intestinal epithelial cells serves as a potential new strategy for treating #depression.
https://www.sciencedirect.com/science/article/pii/S014976342300372X

New findings suggest that the #mitochondria of #intestinal epithelial cell may be a newly found important factor in the pathogenesis of #depression & represent a potential new strategy for treating depression.
https://www.sciencedirect.com/science/article/pii/S014976342300372X

Rosalind Xu is up!
From Moffitt lab at Harvard Med and Children's Hospital
https://moffittlab.github.io/people.html

"A single-cell spatial atlas of the mouse gut reveals spatial- and microbiota-dependent sensation"

Using MERFISH which was developed for brain, so she had to develop protocol that works in gut

#SingleCell
#CSSingleCells23
#microbiota
#intestinal
#Transcriptomics

Ars Technica: Here’s what happens when a swim team competes with an intestinal pathogen https://arstechnica.com/?p=1951178 #Tech #arstechnica #IT #Technology #waterbornedisease #Cryptosporidium #cryptoexchange #massachusetts #intestinal #diarrhea #parasite #pathogen #swimmers #swimming #Science #college #Health #pool #CDC

Long COVID: The Persistence of #SARSCoV2 in the Mucous Membranes May Be A Factor - https://presse.inserm.fr/en/covid-long-la-persistance-du-sars-cov-2-dans-les-muqueuses-pourrait-etre-en-cause/66975/ “initial severity of #COVID is associated with a higher risk of developing #longCOVID,” specify the researchers. “One hypothesis is that people with more exacerbated early #immunodeficiency develop more severe initial forms of #COVID19 and fail to effectively eliminate the virus that passes into the #intestinal mucosa, where it settles for a long time.”

2019: #Gut #microbiota and #neurological effects of #glyphosate

Abstract: "There are currently various concerns regarding certain environmental toxins and the possible impact they can have on developmental diseases. Glyphosate (Gly) is the most utilised herbicide in agriculture, although its widespread use is generating controversy in the scientific world because of its probable #carcinogenic effect on human cells. Gly performs as an inhibitor of 5-enolpyruvylshikimate-3-phospate synthase (EPSP synthase), not only in plants, but also in bacteria. An inhibiting effect on EPSP synthase from intestinal microbiota has been reported, affecting mainly beneficial bacteria. To the contrary, Clostridium spp. and Salmonella strains are shown to be resistant to Gly. Consequently, researchers have suggested that Gly can cause dysbiosis, a phenomenon which is characterised by an imbalance between beneficial and pathogenic microorganisms. The overgrowth of bacteria such as #clostridia generates high levels of noxious metabolites in the #brain, which can contribute to the development of neurological deviations. This work reviews the impact of Glyphosate-induced #intestinal dysbiosis on the central nervous system, focusing on emotional, #neurological and #neurodegenerative disorders. A wide variety of factors were investigated in relation to brain-related changes, including highlighting #genetic abnormalities, #pregnancy-associated problems, #diet, #infections, vaccines and heavy metals. However, more studies are required to determine the implication of the most internationally used #herbicide, Gly, in behavioural disorders."

#RoundUp #Herbicides #Soy #Wheat #Corn

Read more:
https://pubmed.ncbi.nlm.nih.gov/31442459/

A species of ordinary #gut #bacteria that we all carry flourishes when the #intestinal #flora is knocked out by a course of #antibiotics. Since the bacteria is naturally resistant to many antibiotics, it causes problems, particularly in #healthcare settings.
#Microbiology #Chemistry #Pharmaceutical #sflorg
https://www.sflorg.com/2023/04/mcb04182301.html

How is #selfrenewal of #intestinal #stemcells at the crypt base regulated?

Zusen Fan and coworkers identify #circBtnl1 circular RNA #circRNA that inhibits ISC self-renewal via #mRNA decay of #Sox9 #transcription activator #Atf4

https://www.embopress.org/doi/10.15252/embj.2022112039

Cover feature in issue 42/2:

#Golgi #oxygen sensor controlling #intestinal ‘mucin #glycosylation
by Tal Ilani, Deborah Fass and colleagues with SciStories.com

And:
Gut colonization via #GTPase-less EF-G paralog
#Yeast cells in two minds about #cellcycle start
#MASTL/#PP2A module restraining #PI3K-Akt
Zinc-dependent structural transition in ALS-mutated #SOD1
https://www.embopress.org/toc/14602075/2023/42/2

Rinse aids in #commercial #dishwashers often contain #alcohol #ethoxylate. This substance damages the #intestinal #epithelium, which can lead to chronic #diseases.
#Medical #Microbiology #sflorg
https://www.sflorg.com/2022/12/med12012201.html

Did you know that starting a high-fat #diet causes an adaptation of the #intestinal #epithelium within only 24 hours?

In this interesting study, Jacob Enriquez and colleagues at Cincinnati Children's Hospital Medical Center used physiological metrics and single-cell transcriptomics to interrogate the intestinal epithelial cell response to a high-fat diet in mice.

Article in Cell Reports: https://www.cell.com/cell-reports/fulltext/S2211-1247(22)01512-1

#Intestinal #bacteria composition is crucial to driving the recovery of #neutrophils counts in the blood of mice following treatments such as stem cell #transplants or #chemotherapy.
#Microbiology #Biology #Medical #sflorg
https://www.sflorg.com/2022/11/mcb11212201.html

I’m a little late with an introduction post but we study #malaria transmission, particularly how changes in mammalian host #immunity and #metabolism control parasite transmission to and infection of the #mosquito host. We’re also interested in how malaria-induced activation of #basophils and #mast cells disrupts #intestinal barrier integrity. I’m passionate about #training that highlights the direct connections among #plant, #animal and #human health from the #cellular to the #ecosystem scales.