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#inflammation

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David Usharauli

Mutations don’t act in isolation! 🧬🦠 These findings highlight the need to consider how genetic changes especially immune-related ones influence endogenous microbiota and, in turn, host physiology.

#microbiota
#Immunology
#inflammation
#genetics

biorxiv.org/content/10.1101/20

bioRxiv · Susceptibility of Kit-mutant mice to sepsis caused by enteral dysbiosis, not mast cell deficiencyKit-mutant mice are highly susceptible to polymicrobial sepsis elicited by cecal ligation and puncture (CLP). This vulnerability has been attributed to the mast cell deficiency of Kit mutants, suggesting important roles of mast cells in defense against bacteria. We show here that mice lacking mast cells but wild-type for Kit are as resistant to sepsis as mast cell-proficient mice, excluding mast cells as protective factor. Induction of sepsis by direct injection of intestinal microbiota instead of surgical gut perforation revealed comparable protection of Kit-deficient and Kit wild-type mice, indicating normal bacterial immune defense in the absence of Kit. Notably, compared to wild-type mice, we observed more that 1000-fold greater E. coli colony-forming units in the cecal content of Kit-mutant mice, consistent with dysbiosis from gastrointestinal pathophysiology. Thus, upon intestinal puncture, this vast overrepresentation of pathogenic bacteria led to incomparable infections, likely explaining the apparent susceptibility of Kit-mutants. These findings highlight the importance of considering potential effects of genetic mutations on endogenous microbiota composition in cecal ligation and puncture studies of mutant mice. Collectively, our results suggest that the susceptibility of Kit-mutant mice to sepsis is associated with their enteral dysbiosis rather than mast cell-deficiency. ### Competing Interest Statement The authors have declared no competing interest.
Public
Bytes Europe

Impact of excessive alcohol consumption on digestive health byteseu.com/825831/ #alcohol #Cancer #carcinoma #Chronic #Cirrhosis #Colorectal #ColorectalCancer #Compound #DigestiveSystem #dna #EsophagealCancer #ethanol #Fibrosis #Gallstones #GastricCancer #gastroenterology #GastrointestinalTract #Genetic #Health #Inflammation #Liver #Metabolism #Pancreas #Pancreatitis #PublicHealth #Smoking #Steatosis

Bytes Europe · Impact of excessive alcohol consumption on digestive healthExcessive alcohol consumption is a significant public health concern, responsible for approximately 6% of all deaths and contributing to 5.1% of the global disease burden. Alcohol use is a major risk factor for over 200 diseases, including liver cirrhosis, pancreatitis, and esophageal cancer, with a particularly high incidence of gastrointestinal diseases. More than 50% of alcohol-related deaths are caused by gastrointestinal diseases, highlighting the importance of understanding how ethanol affects the digestive system. This review aims to provide an overview of ethanol metabolism and the diseases caused by alcohol consumption, with a focus on the liver, gastrointestinal tract, pancreas, and
Public
Howard Smith MD, AM

Flossing Lowers Stroke Risk: Those who flossed at least once weekly had a 21% lower incidence of ischemic stroke and a 44% lower risk of stroke associated with atrial fibrillation. #flossing #stroke #periodontitis #plaque #inflammation #atrialfibrillation
instagram.com/drhowardsmithrep

InstagramHoward G. Smith MD, AM on Instagram: "Flossing Lowers Stroke Risk University of South Carolina neurologists just reported to the International Stroke Conference that that regular flossing lowers the risk of certain strokes. Their study followed 6,278 participants for more than 25 years. Those who flossed at least once weekly had a 21% lower incidence of ischemic stroke and a 44% lower risk of stroke associated with atrial fibrillation. The flossing prevents gum disease and reduces plaque buildup that both increase the level of inflammation in brain blood vessels but also in the heart leading to atrial fibrillation. There is growing evidence that oral health is closely linked to heart health. Regular flossing as well as brushing are habits that have major health benefits. The study looked at once a week, but we all should be flossing as well as brushing after every meal. https://www.medscape.com/viewarticle/regular-flossing-tied-reduced-ischemic-stroke-risk-2025a10002t7?ecd=a2a #flossing #stroke #periodontitis #plaque #inflammation #atrialfibrillation"0 likes, 0 comments - drhowardsmithreports on March 11, 2025: "Flossing Lowers Stroke Risk University of South Carolina neurologists just reported to the International Stroke Conference that that regular flossing lowers the risk of certain strokes. Their study followed 6,278 participants for more than 25 years. Those who flossed at least once weekly had a 21% lower incidence of ischemic stroke and a 44% lower risk of stroke associated with atrial fibrillation. The flossing prevents gum disease and reduces plaque buildup that both increase the level of inflammation in brain blood vessels but also in the heart leading to atrial fibrillation. There is growing evidence that oral health is closely linked to heart health. Regular flossing as well as brushing are habits that have major health benefits. The study looked at once a week, but we all should be flossing as well as brushing after every meal. https://www.medscape.com/viewarticle/regular-flossing-tied-reduced-ischemic-stroke-risk-2025a10002t7?ecd=a2a #flossing #stroke #periodontitis #plaque #inflammation #atrialfibrillation".
Public
Technische Universität München

Scientists at our university and LMU University Hospital Munich combine dietary therapy with fecal microbiome transfer to improve long-term treatment for #Crohns disease. By reshaping the #gutmicrobiome, they aim to sustain remission and reduce #inflammation: go.tum.de/395259

📷 A.Eckert

go.tum.deClinical study on new therapy for Crohn's diseaseResearchers from TUM and LMU are investigating a new therapy for Crohn's disease. This involves a "microbiome reboot" followed by a microbiome transfer.
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