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#glycosylation
The #evolution of #hemagglutinin-158 and #neuraminidase-88 #glycosylation sites modulates antigenicity and #pathogenicity of clade 2.3.2.1 #H5N1 avian #influenza viruses, https://etidiohnew.blogspot.com/2024/12/the-evolution-of-hemagglutinin-158-and.html
Keyhole Limpet Hemocyanin (KLH) is used to produce #antibodies and as an #immunostimulant. Interestingly 3-4% of it's weight is #carbohydrate.
In this month's interesting facts about #glycans we take a look at the unusual #glycosylation of KLH.
Read at: https://research.bidmc.org/ncfg/blog/facts-about-keyhole-limpet-hemocyanin-klh-and-its-unusual-glycosylation
Immune Evasion, #Cell-Cell #Fusion, and #Spike Stability of the #SARS-CoV-2 #XEC #Variant: Role of #Glycosylation #Mutations at the N-terminal Domain
Source: BioRxIV, AbstractSARS-CoV-2 continues to evolve, producing new variants that drive global COVID-19 surges. XEC, a recombinant of KS.1.1 and KP.3.3, contains T22N and F59S mutations in the spike protein's N-terminal domain (NTD). The T22N mutation, similar to the DelS31 mutation in KP.3.1.1, introduces a potential…
Glycosylation Modulates the Structure and Functions of Collagen: A Review (2024)
In this month's interesting facts about #glycans we look at the #glycoprotein collagen and its unique #glycosylation
Read the post: https://research.bidmc.org/ncfg/blog/facts-about-collagen-and-its-glycosylation-one-most-common-glycoproteins-all-animals
For more interesting facts check: https://research.bidmc.org/ncfg/interestingfacts/interesting-facts-about-glycans
#Hemagglutinin #glycosylation pattern-specific effects: implications for the #fitness of H9.4.2.5-branched #H9N2 avian #influenza viruses, Emerg Microbes Infect.: https://www.tandfonline.com/doi/full/10.1080/22221751.2024.2364736
Overall, our study provides a systematic insight into how changes in HA glycosylation patterns regulate the evolutionary fitness and epidemiological dominance drift of h9.4.2.5-branched H9N2 AIVs, which will be of great benefit for the glycosylation-dependent vaccine design.
Avian #influenza virus #NA #stalk length & #HA #glycosylation patterns reveal molecularly directed #reassortment promoting emergence of highly pathogenic #clade 2.3.4.4b A (#H5N1) viruses http://biorxiv.org/cgi/content/short/2024.05.22.595329v1?rss=1
These observations led us to establish and validate hypothesis that pairing of avian virus HA & NA subtypes is not stochastic but is rather molecularly programmed by HA glycosylation & NA stalk length, modulating fitness & emergence of novel avian influenza viruses.
This month on our blog - we highlight interesting facts about Pectin - One of the Most Complex Polysaccharides in Nature and its Healing Properties.
For more interesting facts about glycans check out our page: https://research.bidmc.org/ncfg/interestingfacts/interesting-facts-about-glycans
Many #Asgard #Archaea have a multiprotein complex #oligosaccharyltransferase https://www.nature.com/articles/s41586-023-06186-2 This is wild! The established view was that the ancestral eukaryote had a single protein Stt3 enzyme and subunits were added during eukaryotic evolution to regulate #glycosylation.
The #MGAT5 #glycosylation #enzyme plays a crucial role in #brain development, according to a study by University of California, Irvine researchers, a discovery that may contribute to new therapeutic purposes for #neural stem cells.
#Neuroscience #Biology #sflorg
https://www.sflorg.com/2023/05/ns05162301.html
Referenced link: https://medicalxpress.com/news/2023-05-team-glycosylation-enzyme-critical-brain.html
Discuss on https://discu.eu/q/https://medicalxpress.com/news/2023-05-team-glycosylation-enzyme-critical-brain.html
Originally posted by Phys.org / @physorg_com: http://nitter.platypush.tech/medical_xpress/status/1658553920011096071#m
RT by @physorg_com: Research team identifies #glycosylation enzyme critical in brain formation @ISSCR https://linkinghub.elsevier.com/retrieve/pii/S2213671123001418 https://medicalxpress.com/news/2023-05-team-glycosylation-enzyme-critical-brain.html
Do you know the mammalian monosaccharides? Most people who know their #aminoacids and #nucleotides answer no to this quesion... Want to learn? Download our new #glycogang #glycotime poster today! http://glyco-alberta.ca/educational-resources/ (in the for educators tab). Learn more about #glycosylation #education #biochemistry
Interesting! ST3GAL1 sialylates CD18, inducing nonspecific tissue sequestration of CAR-T cells by altering LFA-1 endocytic recycling. CAR-T cells with expression of ßII-spectrin that bind LFA-1 improve tumor-specific homing of CAR T cells. https://tinyurl.com/4w3zhvxs
'Blockade of the inhibitory FcγRIIB in combination with anti–PD-L1 improved antitumor responses. Similarly, afucosylation of the IgG1 Fc region improved antitumor responses, and this was due to alterations in the tumor microenvironment.'
Cover feature in issue 42/2:
#Golgi #oxygen sensor controlling #intestinal ‘mucin #glycosylation
by Tal Ilani, Deborah Fass and colleagues with SciStories.com
And:
Gut colonization via #GTPase-less EF-G paralog
#Yeast cells in two minds about #cellcycle start
#MASTL/#PP2A module restraining #PI3K-Akt
Zinc-dependent structural transition in ALS-mutated #SOD1
https://www.embopress.org/toc/14602075/2023/42/2
What determines specificity of #flagellin #glycosylation in #bacteria?
Patrick Viollier, Nicolas Kint et al reveal #stereoisomer selectivity wired into species-specific C-terminal domain of #FlmG #glycosyltransferases
"Our results suggest that, in a cellular context, Fab glycans inhibit IgG–hFcRn interaction and thus negatively affect the transplacental transfer of IgG. As Fab-glycosylated Abs are frequently associated with autoimmune and malignant disorders and may be potentially harmful, this might encompass a regulatory mechanism, limiting the half-life and transport of such Abs."
@profcelentyx @cellpress Interesting... I get #IgG infusions for #immunodeficiency. Some batches cause severe knee joint pain-worse than my baseline and the joints make horrible noises. Now I'm wondering if the IgG is inflammatory sometimes? I've only started IgG a year ago so I don't know what it was like in the before times. Are there other diseases that do this or just covid? I was unaware of #glycosylation until now.
#Introduction time! I'm a professor at the #UniversityOfQueensland interested in #glycosylation #glycotime #MassSpectrometry #virology #yeast #wine and #beer! https://scmb.uq.edu.au/profile/75/benjamin-schulz