We bumped into #preLighter and former intern (also @the_node & @focalplane_jcs) Ryan Harrison. #biologists100

Here, he presented a beautiful (pink ) poster detailing his work on cell organisation & 3D shape emergence in a posterior neuruloid system.

#Comparison of Contemporary and Historic Highly Pathogenic Avian #Influenza A(#H5N1) Virus #Replication in #Human #Lung #Organoids, https://etidiohnew.blogspot.com/2025/01/comparison-of-contemporary-and-historic.html

PhD Opportunity with me!

Calling for aspiring bioengineers to join us!

Develop organotypic models to explore host-microbe dynamics due to metabolic signals. Work with tissue systems, biofilms, imaging, and mass spectrometry.

Get in touch, and apply here: https://www.cpm.qmul.ac.uk/cdt/applications/

How well do human neural #organoids replicate brain biology? @JonathanMWerner & Jesse Gillis compare >170 gene expression profiles between primary tissue & neural organoids to quantify biological fidelity across diverse organoid models #PLOSBiology https://plos.io/3ZlFBJo

Just published

Human Brain Organoids

https://link.springer.com/book/10.1007/978-3-031-72371-1

This book explores the ethical challenges of brain organoid research, offering guidance through collaboration between neuroscientists and ethicists. It aims to foster understanding and responsible management of this groundbreaking field.

Enjoy

#Bioethics #Organoids #Research #Neuroscience #Neuroethics #Bioengineering #Ethics #StemCells #Interdisciplinarity #Consciousness #Collaboration #AI #Books @Harvard

What if we could model Alzheimer’s disease in a dish? Well now we can!

Manuel Lessi covers work from the Xu Lab describing an innovative organoid platform that captures the cellular diversity of the human brain.

Check out his preLight + responses from the authors

https://prelights.biologists.com/highlights/alzheimers-disease-patient-brain-extracts-induce-multiple-pathologies-in-vascularized-neuroimmune-organoids-for-disease-modeling-and-drug-discovery/

Mind blowing stuff from Sergiu Pasca as always... four distinct types of brain organoids connected in their in vivo context and showing synchronised firing patterns.

https://www.biorxiv.org/content/10.1101/2024.10.13.617729v1

53BP1 regulates gene expression for #tumor suppression & #neural development, how is it regulated? This study shows that phosphorylation of 53BP1 by #ATM kinase is crucial for modulating genetic programs in neural progenitors & cortical #organoids #PLOSBiology https://plos.io/3XKEm70

Autism Severity Linked to Brain Overgrowth, Research Shows
https://scitechdaily.com/autism-severity-linked-to-brain-overgrowth-research-shows/ #autism #neurophysiology #BrainGrowth #development #ASD #organoids #neurons

LOL, "General AI"-Diskurs (AGI) mal anders rum:

Can Brain ‘#Organoids’ Become Sentient? A Neuroscientist Tries to Answer the Startling Question

https://www.inverse.com/science/brain-organoids-become-sentient-neuroscientist-bci-technology

New paper @PLOSPathogens: Infection of human #organoids supports an intestinal niche for #Chlamydia trachomatis. @lab_rudel @Uni_WUE @SinaBartfeld @TUBerlin
https://nachrichten.idw-online.de/2024/08/23/chlamydia-can-settle-in-the-intestine

Human Brain Cells’ Potential in Computer Design Is Imminent #brain #computers #organoids #diseases #programs #medicine #computerinterfaces https://buff.ly/4csy0gB

Enhanced #replication of contemporary #human #HPAI #H5N1 virus isolate in human #lung #organoids compared to bovine isolate, BioRxIV: https://www.biorxiv.org/content/10.1101/2024.08.02.606417v1

Compared virus replication & host responses in human alveolar epithelium infected with H5N1 viruses. A/Vietnam/04 replicated most efficiently, followed by A/Texas/24, then A/bovine/Ohio/24. Induction of IF-stimulated genes was lower w/A/Texas/24 & A/bovine/Ohio/24, which may indicate a reduced disease severity of these viruses.

Scientists just grew the 1st-ever 'minibrains' from multiple people's cells
https://www.livescience.com/health/neuroscience/scientists-just-grew-the-1st-ever-minibrains-from-multiple-peoples-cells #biology #brain #organoids #minibrains #hybrid #chimera #chimeroids

Earliest Biological Signals of Autism Found in Mini-Brains Experiment
https://www.sciencealert.com/earliest-biological-signals-of-autism-found-in-mini-brains-experiment #psychology #brain #autism #mini—brains #iPSCs #organoids #BCOs #ASD

NIH Study Confirms: Humans Unlikely To Catch Deer Prion Disease
https://scitechdaily.com/nih-study-confirms-humans-unlikely-to-catch-deer-prion-disease/ Health #disease #prion #deer #ChronicWasting #cerebral #organoids #species #barrier

World's first #bioprocessor uses 16 #human brain #organoids for ‘a million times less power’ consumption than a digital #chip | Tom's Hardware #technology #gamechanger
https://www.tomshardware.com/pc-components/cpus/worlds-first-bioprocessor-uses-16-human-brain-organoids-for-a-million-times-less-power-consumption-than-a-digital-chip

Check out the latest preprint from David Butler & team: development of an #intrabody collection that targets a-Synuclein, a key protein that accumulates in Parkinson's disease. Efficacy data were generated using #organoids from PD patient stem cell lines in vitro as well as with two in vivo models.

#ParkinsonAwarenessMonth #NeuraCell

This work was supported by the Michael J. Fox Foundation, Parkinson's Foundation, NIH's NIDDK & NIA, & NYSDOH.

Preprint | https://zurl.co/M4aF

4-APR-2024
Shaking tiny clusters of #brain cells, scientists reveal an overlooked protein’s role in traumatic brain injury

https://www.eurekalert.org/news-releases/1039503 #science #organoids #StemCells #neuroscience