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PLOS BiologyMutations in SOD1 gene can cause <a href="https://fediscience.org/tags/familialALS" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#familialALS</a> in a process involving dissociation of the <a href="https://fediscience.org/tags/SOD1" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#SOD1</a> dimer. This study shows that a novel cyclic thiosulfinate cross-linker can stabilize the SOD1 dimer in vivo, with therapeutic implications for fALS <a href="https://fediscience.org/tags/PLOSBiology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#PLOSBiology</a> <a href="https://plos.io/3UpT8yL" rel="nofollow noopener noreferrer" target="_blank">https://plos.io/3UpT8yL</a>

Monica Di, PhD :verified:<a href="https://med-mastodon.com/tags/FDA" class="mention hashtag" rel="tag">#FDA</a> just approved Qalsody (tofersen) for <a href="https://med-mastodon.com/tags/ALS" class="mention hashtag" rel="tag">#ALS</a> with <a href="https://med-mastodon.com/tags/SOD1" class="mention hashtag" rel="tag">#SOD1</a> mutation (~2% of ALS cases), based on a ⬇️ of the <a href="https://med-mastodon.com/tags/biomarker" class="mention hashtag" rel="tag">#biomarker</a> neurofilament (NFL) in the plasma. 🔹 ALS is a progressive neurodegenerative disorder, attacking nerve cells that control voluntary muscles (e.g., breathing) 🔹 Qalsody is given intrathecally (in the spine) with 3 initial doses at 14-day intervals and maintenance every 28 days 🔹 Most common side effects were pain, fatigue, joint pain, ⬆️ white blood cells in the CSF, and muscle pain

The EMBO JournalCover feature in issue 42/2:<a href="https://sciencemastodon.com/tags/Golgi" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Golgi</a> <a href="https://sciencemastodon.com/tags/oxygen" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#oxygen</a> sensor controlling <a href="https://sciencemastodon.com/tags/intestinal" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#intestinal</a> ‘mucin <a href="https://sciencemastodon.com/tags/glycosylation" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#glycosylation</a> by Tal Ilani, Deborah Fass and colleagues with SciStories.comAnd: Gut colonization via <a href="https://sciencemastodon.com/tags/GTPase" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#GTPase</a>-less EF-G paralog <a href="https://sciencemastodon.com/tags/Yeast" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Yeast</a> cells in two minds about <a href="https://sciencemastodon.com/tags/cellcycle" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#cellcycle</a> start <a href="https://sciencemastodon.com/tags/MASTL" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#MASTL</a>/#PP2A module restraining <a href="https://sciencemastodon.com/tags/PI3K" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#PI3K</a>-Akt Zinc-dependent structural transition in ALS-mutated <a href="https://sciencemastodon.com/tags/SOD1" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#SOD1</a> <a href="https://www.embopress.org/toc/14602075/2023/42/2" rel="nofollow noopener noreferrer" target="_blank">https://www.embopress.org/toc/14602075/2023/42/2</a>

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