It's my birthday and I'm sick and it's alright.

I had #longcovid in 2022 and developed an #immunodeficiency (igg2 SAD) from it. I basically spent a good part of that year in bed. It was a pause on my whole life, and I'm still rebuilding it.

I learned some skills for this moment that I forget when I'm well. Mostly: you can't do anything when you're not caring for yourself. And in periods of overwhelm, next right action is the only thing that matters - to yourself and the collective

According to an excellent explanation from #TACT the wave of mystery pneumonias follows in time and space any wave of #pirola aka the #BA286 family.
In particular the most infectious variant to date, #JN1 "with extreme immune evasion and suppression". In other words, this is the variant most likely to induce #immunodeficiency.
Anything that can cause "secondary" pneumonia is on the list, particularly in children and the elderly whose immune systems are already weakened.
At the end of the article, there is a warning that adults will be the next to be affected, in the coming weeks.
Source: https://tactnowinfo.substack.com/p/the-cause-of-the-mysterious-pneumonia?utm_source=post-email-title&publication_id=1225454&post_id=139291689&utm_campaign=email-post-title&isFreemail=true&r=lr6zj&utm_medium=email
#COVID #Immunodefficiency #Pneumonia #MysteriousDisease

New research combining computer modeling and experiments with macaques shows the body’s #immune system helps control human #immunodeficiency virus (HIV) #infections largely by suppressing viral production in already infected cells while also killing #viral infected cells
#Biology #Virology #HIV #sflorg
https://www.sflorg.com/2023/10/bio10312301.html

There does not seem to be any rhyme or reason to when I feel well. So far, today is a good day. Yesterday was a very high pain day.

Results are still pending for the major autoimmune blood test and my theory is that it was positive so they had to run more tests.

I do have something called hypogammaglobulinemia which explains why I get sick so easily. Sigh. At least I never stopped masking.

https://en.m.wikipedia.org/wiki/Hypogammaglobulinemia

Immunodeficiency in humans is not good.

Wearing masks, improving ventilation, avoiding crowds and getting fully vaccinated and boosted can help avoid it and keep your immune system healthier.

https://www.nature.com/articles/s41392-021-00749-3

Researchers explore how patients with a rare and severe #immunodeficiency were still able to defend themselves normally against #viruses, including #COVID-19
#Medical #Biology #Virology #sflorg
https://www.sflorg.com/2023/05/med05082302.html

A new UCLA-led study suggests that advanced #genome #editing #technology could be used as a one-time treatment for the rare and deadly genetic #disease #CD3 delta severe combined #immunodeficiency.
#Medical #Biology #sflorg #Science
https://www.sflorg.com/2023/03/med03212301.html

New primary atopic disorder / monogenic gastrointestinal disease!
---
RT @JExpMed
International collaborative team discover that gain-of-function variants in STAT6 explain some cases of severe, early-onset allergic disease: https://bit.ly/3J81uEa
@TurveyLab @casanova_lab @dan_leung_ @BeziatV @IsabelleMeyts
#allergies #immunodeficiency
https://twitter.com/JExpMed/status/1633550425218764801

A newly discovered #immunodeficiency in children should expand the catalogue documenting such diagnostic genes. Researchers from #mdcBerlin, ECRC and Charité Berlin identified a mutation in a transcription factor that plays a key role in the #ImmuneSystem: https://www.mdc-berlin.de/news/press/inborn-immunodeficiency-discovered-and-explained

There is an ongoing debate right now about "immunodeficiency" effects of #Covid19 .

I went back to its definition again so..

#immunodeficiency

https://www.ncbi.nlm.nih.gov/books/NBK500027/

Recently Published!

Immunodeficiency, Leukemia, and Lymphoma

https://link.springer.com/chapter/10.1007/16833_2022_82

Lentiviral Gene Therapy for Artemis-Deficient SCID
#immunology #ImmunologyMastodon #immunodeficiency #genetherapy https://www.nejm.org/doi/full/10.1056/NEJMoa2206575?query=TOC&ssotoken=U2FsdGVkX1%2FHRBcFgjORF00I2MUyqu10WliErDNHp0C5LVkEd2Bz204VoiDBv7BqiNzLbfIIB52zQ2GI6mzY3lt0mnroAel1A25DNPeYqprqPt2lF%2BOBrhDDitT%2BMLFglpMSpdh89Zxed5IaIHsyFJW42Nc%2F%2BGpYBu6hlJYccd23jd2jVOIIz8iF69uQ58SmcaK9nC9YzDQoX9%2FzGDiqQw%3D%3D&cid=NEJM%20eToc,%20December%2022,%202022%20DM1802081_NEJM_Non_Subscriber&bid=1326909370

Ignore the title and reference to ivermectin. This article is not primarily political, but the title reflects how the pandemic in general is political. Don't let that turn you off.

The article explains our situation really well, including why so many hospitals are filling with sick kids. It's important that people understand the issues discussed in this post.

#immunodeficiency #ImmuneDysfunction #immunityDebt #LongCovid #postCOVID #OrganDamage #RSV #Strep #SickKids

https://thegauntlet.substack.com/p/with-immunity-debt-democrats-are

RT/ Dr. @lisa_iannattone is pulling no punches. ​

"It’s absolutely wild to me that we’re pretending that the higher than average number of #respiratory tract infections and the pandemic of adults with pneumonia this year is not a warning sign of #immune impairment.

This is literally how #immunodeficiency would present."

This is a fabulous post on why people are sicker this year than in years past.

#Flu #RSV #Influenza #Fever #Cough

Hint: it's not #ImmunityDebt

#immunodeficiency #CovidIsNotOver

https://jessicawildfire.substack.com/p/it-was-never-mild-and-we-dont-have

@tootiatricians @jessicawildfire

@profcelentyx @cellpress Interesting... I get #IgG infusions for #immunodeficiency. Some batches cause severe knee joint pain-worse than my baseline and the joints make horrible noises. Now I'm wondering if the IgG is inflammatory sometimes? I've only started IgG a year ago so I don't know what it was like in the before times. Are there other diseases that do this or just covid? I was unaware of #glycosylation until now.

#introduction

I have #MECFS #ehlersdanlos #posturalorthostatictachycardiasyndrome #MCAS #immunodeficiency etc..

I spend a lot of time reading research trying to find something to help me be more functional. MCAS was a big cause of pain, but the fatigue portion I haven't made much progress.

Now I'm just trying to not get covid-I don't need new problems. Sadly vaccines don't work on me & reactivated my EBV.

Otherwise I make art, and have kitties, and foster kittens.

First steps here and learning! Time for #introduction part2 with hashtags. I’m a physician-scientist in Helsinki (the happiest people on Earth live here!) and topics close to my heart are (not in any order) #thymus #myastheniagravis #aps1 #AIRE #helios #Tfh #tregs #MAITs #RTEs #thymopoiesis #immunodeficiency #immunology #immunophenotyping #flowcytometry #humanimmunology #viruses #viralimmunology #GerminalCenters #SingleCell #Transcriptomics - here to read and learn more about these!