'Although COVID-19 was originally considered a respiratory illness, it is now well established that #SARSCoV2 infection can have far-reaching impacts on the nervous system.' @virusesimmunity.bsky.social @jannamoen.bsky.social @bakermind.bsky.social #Yale

https://onlinelibrary.wiley.com/doi/10.1111/pcn.13855?utm_medium=email&utm_source=substack

UPDATED: Northern Health est.'d #COVID19 cases, extrapolated from #PrinceGeorge #wastewater #SARSCoV2 load.

According to #BCCDC ww. data: on average, from 6/5 - 6/11, there would've been 19 cases/day in Northern Health ( 18, 5/29 - 6/4).

https://ratnegative.tumblr.com/BCWastewater 5/5

UPDATED: Interior Health est.'d #COVID19 cases, wastewater #SARSCoV2 load.

According to #BCCDC ww. data: on average, from 6/6 - 6/12, there would've been 39 cases/day in Interior Health ( 29, 5/30 - 6/5).

https://ratnegative.tumblr.com/BCWastewater 4/5

UPDATED: Island Health est.'d #COVID19 cases, wastewater #SARSCoV2 load.

According to #BCCDC ww. data: on average, from 6/6 - 6/12, there would've been 43 cases/day in Island Health ( 35, 5/30 - 6/5).

https://ratnegative.tumblr.com/BCWastewater 3/5

UPDATED: Metro #Vancouver est.'d #COVID19 cases, wastewater #SARSCoV2 load.

According to #BCCDC ww. data: on average, from 6/5 - 6/11, there would've been 216 & 619 cases/day in the Van. Coastal & Fraser HAs ( 175 & 494, 5/29 - 6/4).

https://ratnegative.tumblr.com/BCWastewater 2/5

Too bad the main body of https://www.sciencedirect.com/science/article/abs/pii/S0306452225006980 is paywalled. The intro gives a great overview of the current state of knowledge around Long COVID neuropathy:

Specifically neuropsychiatric sequelae appear to be often reported by individuals recovering from COVID-19, with about a third of patients presenting fatigue, brain fog and sleep disturbances, and about one fourth anxiety and depression (Premraj et al., 2022); of particular interest, the prevalence of such symptoms appears to increase when investigating long (beyond 6 months) rather than short term consequences of the infection (Premraj et al., 2022).

Significant longitudinal effects were identified in a large UK Biobank sample by comparing brain MRI scans acquired before and after SARS-CoV-2 infection. The study reported a substantial reduction in cortical thickness, specifically in the orbitofrontal cortex and the parahippocampal gyrus. Additionally, widespread alterations in white matter microstructure were observed, with decreased integrity in tracts involving the orbitofrontal cortex, anterior cingulate cortex, insular regions, and the amygdala (Douaud et al., 2022).

Magnetic resonance imaging studies in patients from 2 to 4 months after infection compared to healthy controls (HC) have shown, independently of illness severity, changes in WM microstructure, especially in the frontal and limbic systems (Qin et al., 2021, Silva et al., 2021), and in functional connectivity, in particular in the visuospatial network (Silva et al., 2021). Similarly, a reduction in fiber density has been reported in association, projection, and commissural tracts (Bispo et al., 2022). Further, recent longitudinal studies showed that WM alterations persist up to 2 years after the infection (Huang et al., 2022, Huang et al., 2023), suggesting that long term consequences of COVID-19 could be associated with long-lasting changes in brain structure.

via @Brad