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#glp1

2 posts2 participants1 post today
Public
DrBob, Neurologist, 🧠Mechanic

GLP-1s Are Crazy Effective — Just Not Cost-Effective

I’ll make the argument that the most effective drugs in the past decade are the GLP-1 receptor agonists, drugs like semaglutide and tirzepatide. At least in terms of weight loss, they are truly unparalleled. They are clearly effective. But are they worth it? Are they cost-effective? That is a much harder question, and, as you’ll see in a minute, despite their amazing effects, the answer — for now, at least — is no.

#mounjaro #ozempic #zepbound #wegovy #glp1
medscape.com/viewarticle/glp-1

Medscape · GLP-1s Are Crazy Effective — Just Not Cost-EffectiveBy F. Perry Wilson, MD, MSCE
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BedastGPT

To be clear: Ozempic is a diabetes drug while Wegovy is the weight loss counterpart. This “new" molecule does NOT address glucose management by improving sensitivity to insulin nor improving insulin response to the consumption of carbs. This new molecule will also NOT have a protective nor regenerative effect on pancreatic beta cell islets as GLP-1 does.

This, strictly, appears to target satiety for weight loss.

The only relation to semaglutide is that it's a peptide and it promotes weight loss. It has no other similarites with GLP-1. The comparison only exists to indicate efficacy of intended effect.

#Diabetes #Ozempic #GLP1
twit.social/@twitnews/11413868

TWiT.socialTWiT News Feed (@twitnews@twit.social)Naturally occurring molecule rivals Ozempic in weight loss, sidesteps side effects - https://medicalxpress.com/news/2025-03-naturally-molecule-rivals-ozempic-weight.html A naturally occurring molecule identified by Stanford Medicine researchers appears similar to semaglutide—also known as Ozempic—in suppressing appetite and reducing body weight. Notably, testing in ... #im
Continued thread
Public
Brittany Trang

Some patients in trials for the newest weight-loss drugs are losing ~too much~ weight, eating peanut butter and skipping doses to avoid losing more.

But that conflicts with the industry's hunger for ever-larger weight loss percentages. How are those two interests getting reconciled?

statnews.com/2025/02/20/too-mu

STAT · How much weight loss is too much? Pharma is pushing the limit with new obesity drugsHow much weight loss is too much? Pharma is pushing the limit with new obesity drugs.
#GLP1#obesity#weightloss
Public
DrBob, Neurologist, 🧠Mechanic

Forget Psychedelics 😵‍💫

Everyone’s Microdosing Ozempic Now 🤔

“Shamoon has joined the wave of people who are taking limited amounts not of psychedelics — to which the microdosing trend usually applies — but of the diabetes drug #Ozempic (#semaglutide), and other #GLP1 receptor agonists like #Mounjaro

They are doing it not primarily for weight loss — the effect that has made Ozempic a Hollywood staple and a reliable awards-show punchline — but for the surprising and widely touted side benefits, particularly its anti-inflammatory properties”

hollywoodreporter.com/lifestyl

Text Shot: Dr. Caroline Messer, a top Manhattan endocrinologist, reported that many of the people asking her about microdosing have come in because they are genetically predisposed to Alzheimer’s. “The key is not decreased blood sugar,” she says, “but decreased inflammation. In patients without diabetes, it doesn’t lower blood sugar but still has an anti-inflammatory effect.” And, it makes sense, she notes, because “Alzheimer’s is sometimes referred to as Type 3 diabetes. The brain in someone with Alzheimer’s exhibits insulin resistance, similar to what is seen in Type 2 diabetes.” Microdosing can have a lasting effect in achieving a mental edge, says Dr. Anetta Reszko, a Park Avenue dermatologist. “Unlike traditional dosing, which primarily targets appetite suppression and glucose regulation, microdosing semaglutide may provide a more gradual, sustained effect on the brain, immune system and overall cellular health,” she notes. “By modulating these pathways, it may help reduce…
Public
Nonya Bidniss :CIAverified:

Eye doctors at the University of Utah Health and elsewhere published the research, which describes several cases of vision complications possibly tied to these obesity and diabetes drugs. The medications were linked to three different eye conditions, all of which can lead to blindness. But as the doctors caution, the cases alone do not prove that GLP-1 drugs can cause these issues, and more research is needed to understand exactly what’s going on. #health #GLP1 gizmodo.com/eye-doctors-are-fi

Gizmodo · Eye Doctors Are Finding New Links Between Ozempic and Vision ProblemsA new case series links GLP-1 use to three different eye conditions, all of which can lead to blindness.
Continued thread
Public
Carolyn Barber, MD

weeks.

“We need more data to understand whether the benefits are sustained over long periods of time, & we don’t know whether these meds carry serious long-term risks after five or 10 years of use,” says @zalaly

And at an unsavory cost of $1-1.3K/month, we need to know. More here @Fortune
🎁 link: shorturl.at/XBEbn


Fortune · Largest-ever Ozempic and GLP-1 drug study finds they lower risk of 42 health conditions, including heart attacks and Alzheimer’s diseaseBy Carolyn Barber
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