#CauliflowerMushroom - #SparassisCrispa.
One of my fave #edible & #medicinal #WildMushrooms. It's found in many places around the world, including forests on #VancouverIsland.
We #forage for these wild #mushrooms & use it in making some soups & stir fry dishes.

It's used often in #traditional #Chinese #medicine #TCM because it contains active #pharmacological ingredients. In order to study its medicinal value better, the genomic sequence of S. crispa was published in Oct 2018.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6207663

Dry weight of the #basidiocarp was found to contain up to 43.6% #BetaGlucan, which was approved for the treatment of #cancer in #Japan & recommended for #COVID19 patients to overcome #inflammation.

Experiments suggest that S. crispa contains chemicals that may stimulate the #ImmuneSystem & has many #biological properties including: #AntiTumor, #antiviral activity (reverse transcriptase inhibitory activity), #neuroprotection, #cardioprotection, #AntiInflammation, #hyperlipidemia, #AntiDiabetic medication, #antimicrobial compounds, & methicillin resistant Staphylococcus aureus #MRSA.

A #YTHDF2/#m6A/NF-κB axis controls #antitumor #immunity by regulating intratumoral #Tregs

Linda Zhang, Chuan He and colleagues

https://www.embopress.org/doi/full/10.15252/embj.2022113126

The powerful new substance could become the basis for #antitumor drugs because it affects the #pathology that leads to the development of malignant #tumors, such as #cancer of the #breast, #lung, #prostate, and #lymph nodes.
#Chemistry #Medical #sflorg
https://www.sflorg.com/2023/01/chm01172301.html

The antitumour effects of caloric restriction are mediated by the gut microbiome

https://www.nature.com/articles/s42255-022-00716-4
#cancer #microbiome #diet #Antitumor

“Personalized cancer vaccines are designed to prime the immune system so that a patient can generate a tailored antitumor response specific to their tumor mutation signature.” https://investors.modernatx.com/news/news-details/2022/Moderna-and-Merck-Announce-mRNA-4157V940-an-Investigational-Personalized-mRNA-Cancer-Vaccine-in-Combination-with-KEYTRUDAR-pembrolizumab-Met-Primary-Efficacy-Endpoint-in-Phase-2b-KEYNOTE-942-Trial/default.aspx

#paperoftheday

Amazing work showing that #genetic #disruption of the #kinase module (CDK) of Mediator complex in chimeric #antigen receptor T cell (CAR T) resulted in enhanced effector function and increased #antitumor activity (disruption of CDK module increases core Mediator #chromatin occupancy at #enhancers)

https://www.science.org/doi/10.1126/science.abn5647