Create accountLogin

Recent searches

No recent searches

Search options

Only available when logged in.
med-mastodon.com is one of the many independent Mastodon servers you can use to participate in the fediverse.
Medical community on Mastodon

Administered by:

Server stats:

413
active users

med-mastodon.com: AboutProfiles directoryPrivacy policy

Mastodon: AboutGet the appKeyboard shortcutsView source codev4.3.7

#preprint

8 posts7 participants0 posts today
Public
preLights

New #preLights post from Vibha Singh! 👀

In this highlighted #preprint, the research team (#NalbantLab) introduces a powerful new approach to studying mechanobiological regulation in cancer. In doing so, they describe how tumour cells manage to “pull” themselves away from the tumour bulk during invasion.

Read the #preLight here 👉 prelights.biologists.com/highl

#CancerResearch#Optogenetics#Mechanobiology
Public
CWTS | Leiden University

🆕 **#preprint** on Academic Collaborations and Public Health co-authored by our colleague @AndreaRE_altibel.

💡 Learn more about how lessons from the history of the tobacco industry collaboration can inform current debates on fossil fuel ties in academia. 👉 zenodo.org/records/15274865.

ZenodoAcademic Collaborations and Public Health: Lessons from Dutch Universities' Tobacco Industry Partnerships for Fossil Fuel TiesTobacco and fossil fuels are both leading commercial drivers of mortality, yet academic collaboration with these industries is treated differently. While the WHO and many academics recognise an “irreconcilable conflict” between the tobacco industry and public health interests, many universities justify fossil fuel collaborations if linked to the energy transition. This report draws lessons from the history of tobacco industry collaborations in the Netherlands to inform current debates on fossil fuel ties in academia. We examine the evolving policies and attitudes toward tobacco in the Netherlands, the industry’s historical and ongoing influence on academia, and parallels with fossil fuel strategies—such as casting doubt on health risks, leveraging industry-funded research, shifting blame, and emphasising consumer responsibility and economic importance.
Public
preLights

The Good, the Bad and the Ugly: How Fgf21 creates (and destroys!) muscle homeostasis

First #preLight from Jórdan Sampar, a PhD student in Developmental Biology #UNICAMP. Here, Jórdan highlights work from the group of Sato Ryuichiro #preprint

Check it out! ⬇️
prelights.biologists.com/highl

#biology#neuroscience#physiology
Public *
conscientious objector🇨🇭🪂

Studie zeigt langfristige Immun- und Stoffwechselschäden nach einer #Corona Infektion.

Die University of California San Francisco, NIH und das Frederick National Cancer Laboratory zeigen, dass COVID-19 zu erheblichen und dauerhaften Veränderungen des Immun- und Stoffwechselsystems betroffener Personen führen kann.

Das heißt neben #LongCovid leider auch #Krebs.

Auch 2025 solltet Ihr besser kein #Corona bekommen.

polybio.org/polybio-supported-

Forscher und Mitarbeiter des Long-term Impact of Infection with Novel Coronavirus (LIINC)-Programms der UCSF stehen am Freitag, den 8. August 2024, im Zuckerberg San Francisco General Hospital in San Francisco. (Foto: Noah Berger)
#Covid#preprint
Public
preLights

Bring bacteria back! 🦠 The influence of microbial manipulation on sugar kelp development.

Jasmine Talevi covers work from Jungsoo Park & team (#ParfreyLab) that highlights the fundamental role microbiomes play across diverse biological systems. #preprint

#preLight ⬇️ 👀
prelights.biologists.com/highl

#biology#ecology#kelp
Public
petersuber

I like this idea for a #LettersToTheEditor #preprint server.
link.springer.com/article/10.1

"Such a preprint server would offer three major benefits…: format-free ease of swift communication, increased author visibility and accountability, and avoiding the homelessness of unpublished [letters]."

PS: I've sent letters to journals that had policies not to publish them, but without saying so anywhere. Once I sent a letter to a new journal that had never received or published one and needed time to think about it. Right now #SocialMedia takes up this slack and does a pretty good job. But posting letters as preprints would give authors more space, prevent even published letters from languishing behind #paywalls, and offer better opportunities for #PIDs, #metadata, and #discoverability.

SpringerLinkReinventing the Letter to the Editor in Science: A Dedicated Preprint Server - Publishing Research QuarterlyAlthough letters to the editor (LTEs, or Correspondence) have a wide range of communicative functions within science, they also present several drawbacks, three of which we highlight: editorial ambiguity, technological limitations and skewed perceptions about their format. An assessment of Scopus (September 16, 2023) indicated that letters account for 1.7% to 3.2% per year, relative to articles and reviews, suggesting that the LTE field is undeveloped. We argue that the creation of a new preprint server, which we name CoArXiv or LettersArXiv, would allow LTEs—with timely and valuable knowledge and insight—to be posted in much the same way as other preprints, and would be one way to overcome needed reform of LTE-publishing culture, ultimately expanding the range of science communication channels for multidisciplinary research. We consider that such a preprint server would offer three major benefits for scientific research: format-free ease of swift communication, increased author visibility and accountability, and avoiding the homelessness of unpublished LTEs.
#ScholComm
Public *
preLights

Listen to your gut – lessons from the brain. 🧠

Dang M. Nguyen & team (#BilboLab) demonstrate how prenatal environmental stressors disrupt gut immune cells, impair synaptic pruning in the gut + contribute to neurodevelopmental issues. #preprint

Another great #preLight by Jeny Jose ⬇️ 👀

prelights.biologists.com/highl

#biology#immunology#neuroscience
Public
Amelia Cervera 🧬

30S-seq redefines the bacterial Ribosome Binding Site.

#Ribosomes #30Ssubunit #ShineDalgarnoMotif #TranslationInitiation #Ecoli #Preprint

biorxiv.org/content/10.1101/20

bioRxiv · 30S-seq redefines the bacterial Ribosome Binding SiteThe translation initiation step is rate limiting for the efficiency of gene expression in all organisms. However, the mechanism of ribosome recruitment to mRNA start sites strikingly differs between eukaryotes and prokaryotes. The eukaryotic small (40S) ribosomal subunit binds 5' end caps and scans for the start codon while the bacterial small (30S) subunit directly binds to the Shine-Dalgarno (SD) motif close to the initiation site. Pioneer studies have shown rare 30S loading events further upstream within 5' untranslated regions (5'UTRs), at ribosome standby sites (1-3). Together with the frequent occurrence of long bacterial mRNA 5'UTRs and degenerated SD sequences, this indicates that the 30S subunit might bind upstream of the SD more commonly than currently thought. We therefore developed 30S-seq to map 30S-mRNA interactions in a bacterial transcriptome (Escherichia coli), inspired by translation complex profile sequencing (TCP-seq) previously used in eukaryotes (4,5). Our results provide new and unsuspected insights into the behaviour of 30S and 70S complexes during the canonical translation initiation process. Notably, 30S subunits are recruited upstream of the start codon, primed to receive the SD released by the departing 70S ribosome. Remarkably, we also find hundreds of non-canonical 30S binding sites within mRNA 5'UTRs, sometimes over 100 nucleotides upstream of the start region. We validated several of these upstream ribosome binding sites, and demonstrated their strong impact on gene expression. Thus, even in bacteria, ribosomes frequently bind mRNAs outside of the start region to initiate translation, challenging the classic ribosome binding site model. ### Competing Interest Statement The authors have declared no competing interest.
ExploreLive feeds
About