Bring bacteria back! The influence of microbial manipulation on sugar kelp development.

Jasmine Talevi covers work from Jungsoo Park & team (#ParfreyLab) that highlights the fundamental role microbiomes play across diverse biological systems. #preprint

#preLight
https://prelights.biologists.com/highlights/an-experimental-test-of-the-influence-of-microbial-manipulation-on-sugar-kelp-saccharina-latissima-supports-the-the-core-influences-host-function-hypothesis/

The tooth, the whole tooth and nothing but the… frog? – the not-so bite-sized mystery of frog tooth re-evolution

Check out this really fun post prepared by Ryan Harrison, covering recent work from the #FraserLab. #preprint

#preLight
https://prelights.biologists.com/highlights/tooth-development-in-frogs-implications-for-the-re-evolution-of-lost-mandibular-teeth-and-the-origin-of-a-morphological-innovation/

An intriguing twist! TDP-43 (linked to #ALS) keeps RNAs out of neuronal projections by making them unstable, preventing RNA buildup in neurites. #preprint from the #TaliaferroLab

Another excellent post prepared by Felipe Del Valle Batalla

#preLight
https://prelights.biologists.com/highlights/tdp-43-directly-inhibits-rna-accumulation-in-neurites-through-modulation-of-rna-stability/

Listen to your gut – lessons from the brain.

Dang M. Nguyen & team (#BilboLab) demonstrate how prenatal environmental stressors disrupt gut immune cells, impair synaptic pruning in the gut + contribute to neurodevelopmental issues. #preprint

Another great #preLight by Jeny Jose

https://prelights.biologists.com/highlights/prenatal-exposure-to-environmental-stressors-alters-gut-macrophage-development-and-gastrointestinal-function-of-male-offspring/

Stalling the stress response: chronic low-level stress inhibits stress granule formation via translation elongation impairment.

New post from Mohammed Jalloh #UniversityofArizona highlighting work from the Ivanov lab. #preprint

#preLight
https://prelights.biologists.com/highlights/chronic-stress-antagonizes-formation-of-stress-granules/

Heads or… Heads?

The Layden & Rentzsch labs identify a possible role for the nervous system as a source of positional information during regeneration in the cnidarian Nematostella vectensis. #preprint

Another great #preLight from Isabella Cisneros

https://prelights.biologists.com/highlights/ectopic-head-regeneration-after-nervous-system-ablation-in-a-sea-anemone/

Hyaluronic acid deposition & a soft ECM promote digit regeneration in mice.

@JontyTownson covers the first #preprint from the Storer lab.

Jonathan: "I really appreciated the combination of many different techniques to build a compelling narrative about the role of different cell types regulating HA networks in regenerative wounds and the influence stiffness has on this process."

#preLight

https://prelights.biologists.com/highlights/hyaluronic-acid-and-emergent-tissue-mechanics-orchestrate-digit-tip-regeneration/

A biological phenomenon triggers faster evolution rates in woodland salamanders

Stefan Friedrich Wirth posted a #preLight covering work from Brian Waldron & team. #preprint

Stefan: “The authors were able to use a (…) suitable model to address a topic that researchers in zoology are often confronted with: polymorphisms.”

#preLight
https://prelights.biologists.com/highlights/loss-of-a-morph-is-associated-with-asymmetric-character-release-in-a-radiation-of-woodland-salamanders/

Hearts in time

The first #preLight of Theodora Stougiannou covers work (from Boris Martinac & team) showing that deletion of the Piezo1 gene in mice results in reduced survival, premature cardiac ageing and fibrosis. #preprint

Take a look! https://prelights.biologists.com/highlights/deletion-of-piezo1-in-adult-cardiomyocytes-accelerates-cardiac-aging-and-causes-premature-death/

Two new preLights today

Say hi to the new ChatGPT.. for proteins!

Jawdat Sandakly covers a #preprint in which the authors (Fajie Yuan & team) introduce #Evolla, a large-scale model designed to answer functional protein questions.

#preLight!
https://prelights.biologists.com/highlights/decoding-the-molecular-language-of-proteins-with-evolla/

What’s that on your tail?

Sidney Leedham, Roger Kissane & James Charles review an exciting #preprint from Andrew K. Schulz & team exploring how the development of a scaly-organ at the base of the tail of flying squirrels helps them stick to trees.

#preLight: https://prelights.biologists.com/highlights/scaly-tail-organ-enhances-static-stability-during-pels-scaly-tailed-flying-squirrels-arboreal-locomotion/

The megakaryocyte: trapped in a cage of its own making 𐂺

In this #preprint, Claire Masson & colleagues report the discovery of novel structures controlling megakaryocyte protrusion events.

Excellent #preLight from Simon Cleary

https://prelights.biologists.com/highlights/megakaryocyte_cages/

Targeting the root of NLRP3 inflammation

This #preprint from Rebecca Coll & team “highlights the complexity of immune signaling and the importance of considering many variables (...) when developing (…) therapeutic compounds”

Excellent #preLight prepared by Roberto Amadio

https://prelights.biologists.com/highlights/discovery-of-a-potent-and-selective-inhibitor-of-human-nlrp3-with-a-novel-binding-modality-and-mechanism-of-action/

Another excellent preLight prepared by Felipe Del Valle Batalla

He highlights work showing that Fis1 regulates dendritic mitochondrial dynamics by promoting fission/fusion balance and motility, impacting neuronal function and connectivity. #preprint

#preLight
https://prelights.biologists.com/highlights/fis1-is-required-for-the-development-of-the-dendritic-mitochondrial-network-in-pyramidal-cortical-neurons/

The smoking gun: Plastic is harmful for your neurons

Manuel Lessi highlights a #preprint describing molecular mechanisms altered by polystyrene nanoplastics in neuronal cells.

#preLight includes a thoughtful discussion with first author Winanto

https://prelights.biologists.com/highlights/polystyrene-nanoplastics-promote-neurodegeneration-by-catalyzing-tdp43-hyperphosphorylation/

Fibrin gels to glue granular units

“…the concept of gluing granular systems using thrombin as a catalyzer is novel and can open up new ways in jam-packed granular microgel applications.” #preprint from James Armstrong & team.

First #preLight of Castro Johnbosco

https://prelights.biologists.com/highlights/coagulative-granular-hydrogels-with-an-enzyme-catalyzed-fibrin-network-for-endogenous-tissue-regeneration/

Adriani Felix just posted two #preLights as part of a wonderful #preprint review initiative led by Marcus Oliveira #UFRJ

Adriani covers work from the Skidmore group, presenting BeHepI as a valuable tool for heparin quality control and structural analysis. Work that paves the way for safer and more effective blood thinners.

#preLight: https://prelights.biologists.com/highlights/enzymatic-access-to-the-rare-%ce%b4ua-1%e2%86%924-glc-3-6-n-sulfated-heparin-disaccharide-implications-for-heparin-quality-control/

Feeling tense? Macrophages sense that!

Macrophages prefer to "nibble" (trogocytose) soft targets and "engulf" (phagocytose) stiff ones. Stiffness matters for immune responses! #preprint #FletcherLab

Check out the #preLight written by Felipe Del Valle Batalla

https://prelights.biologists.com/highlights/target-cell-tension-regulates-macrophage-trogocytosis/