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#BloodBrainBarrier

2 posts2 participants1 post today

DATE: February 25, 2025 at 07:30AM
SOURCE: BioWorld MedTech

Direct article link at end of text block below.

Intranasal bacterium for targeted brain delivery

t.co/pxRktVUnf8

#medtech #bloodbrainbarrier

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t.co/pxRktVUnf8

#medtech

Articles can be found by scrolling down the page at bioworld.com/topics/85-bioworl .

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t.coIntranasal bacterium for targeted brain deliveryIn a recent publication in Cell, researchers from the National University of Singapore and collaborators have proposed using commensal bacteria in the nasal cavity as a delivery vector for precision therapy targeting the OE and brain.

DATE: February 24, 2025 at 05:30PM
SOURCE: BioWorld MedTech

Direct article link at end of text block below.

Intranasal bacterium for targeted brain delivery

t.co/pxRktVTPpA

#medtech #bloodbrainbarrier

Here are any URLs found in the article text:

t.co/pxRktVTPpA

#medtech

Articles can be found by scrolling down the page at bioworld.com/topics/85-bioworl .

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NYU Information for Practice puts out 400-500 good quality health-related research posts per week but its too much for many people, so that bot is limited to just subscribers. You can read it or subscribe at @PsychResearchBot
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Since 1991 The National Psychologist has focused on keeping practicing psychologists current with news, information and items of interest. Check them out for more free articles, resources, and subscription information: nationalpsychologist.com
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t.coIntranasal bacterium for targeted brain deliveryIn a recent publication in Cell, researchers from the National University of Singapore and collaborators have proposed using commensal bacteria in the nasal cavity as a delivery vector for precision therapy targeting the OE and brain.

Microplastics are accumulating in human brains at an alarming rate
youtu.be/0PT5c1z3LL8

Katie Couric did a great job interviewing Dr Matthew J Campen. I'm so grateful when journalists pose smart questions to scientists.

I am wondering if differences in p-glycoprotein function could account for differences in accumulation between individuals since it could affect the rate of efflux across the BBB? (from the fish studies and what Dr Campen said about reaching an equilibrium, it seems there must be at least some efflux). If true, then some medications might affect the amount of microplastic accumulation in the brain since they can change p-glycoprotein function.

The #BloodBrainBarrier, a network of blood vessels and tissues that nurtures and protects the brain from harmful substances circulating in the blood—is disrupted in #AlzheimerDisease. Now, researchers at #MayoClinic and collaborators have uncovered unique #molecular signatures of blood-brain barrier #dysfunction that could point to new ways to diagnose and treat the disease. Their findings are published in Nature Communications.
medicalxpress.com/news/2024-06 #healthcare #publichealth #dementia

Medical Xpress · Researchers identify vascular changes in the brain linked to Alzheimer's diseaseBy Science X

Researchers Target Brain Blood Vessels in Mice With COVID “Brain Fog”

Enhancing Wnt/β-catenin signalling or its downstream effectors could be a potential interventional strategy for restoring cognitive health following viral infections.

Engineered Wnt7a ligands rescue blood-brain barrier and cognitive deficits in a COVID-19 mouse model
academic.oup.com/brain/advance

#BloodBrainBarrier #WntBetaCateninPathway

technologynetworks.com/neurosc

> Paraquat is manufactured by Syngenta, a Swiss-based company owned by the Chinese government. The chemical is banned in at least 58 countries — including China and Switzerland — due to its toxicity, yet it continues to be a popular herbicide in California and other parts of the United States.
> .. the chemical may cross the #BloodBrainBarrier in a manner that triggers #Parkinson's disease,
yahoo.com/news/weed-killer-ban
#paraquat #Syngenta #Herbicide
/HT @jikodesu and @jkn

Yahoo News · This weed killer is banned in 50 countries. U.S. workers say it's giving them Parkinson'sBy Hayley Smith

"This study examined the effects of lung infection causing systemic and neuroinflammation as a potential mechanism contributing to blood-brain barrier (BBB) leakage and behavioral impairment."

#Preprint #Neuroimmunology #BloodBrainBarrier #Immunology #Infection #InfectiousDisease

biorxiv.org/content/10.1101/20

bioRxivLung infection by P. aeruginosa induces neuroinflammation and blood-brain barrier dysfunction in miceBackground Severe lung infection can lead to brain dysfunction and neurobehavioral disorders. The mechanisms that regulate the lung-brain axis of inflammatory response to respiratory infection are incompletely understood. This study examined the effects of lung infection causing systemic and neuroinflammation as a potential mechanism contributing to blood-brain barrier (BBB) leakage and behavioral impairment. Methods Pneumonia was induced in adult C57BL/6 mice by intratracheal inoculation of Pseudomonas aeruginosa (PA). Solute extravasation, histology, immunofluorescence, RT-PCR, multiphoton imaging and neurological testing were performed in this study. Results Lung infection caused alveolar-capillary barrier injury as indicated by leakage of plasma proteins across pulmonary microvessels and histopathological characteristics of pulmonary edema (alveolar wall thickening, microvessel congestion, and neutrophil infiltration). PA also caused significant BBB dysfunction characterized by leakage of different sized molecules across cerebral microvessels and a decreased expression of cell-cell junctions (VE-cadherin, claudin-5) in the brain. BBB leakage peaked at 24 hours and lasted for 7 days post-inoculation. Additionally, mice with lung infection displayed hyperlocomotion and anxiety-like behaviors. To test whether cerebral dysfunction was caused by PA directly or indirectly, we measured bacterial load in multiple organs. While PA loads were detected in the lungs up to 7 days post-inoculation, bacteria were not detected in the brain as evidenced by negative cerebral spinal fluid (CSF) cultures and lack of distribution in different brain regions or isolated cerebral microvessels. However, mice with PA lung infection demonstrated increased mRNA expression in the brain of pro-inflammatory cytokines (IL-1b;, IL-6, and TNF-a;), chemokines (CXCL-1, CXCL-2) and adhesion molecules (VCAM-1 and ICAM-1) along with CD11b+ cell recruitment, corresponding to their increased blood levels of white cells (polymorphonuclear cells) and cytokines. To confirm the direct effect of cytokines on endothelial permeability, we measured cell-cell adhesive barrier resistance and junction morphology in mouse brain microvascular endothelial cell monolayers, where administration of IL-1b; induced a significant reduction of barrier function coupled with tight junction (TJ) diffusion and disorganization. Combined treatment with IL-1b; and TNFa; augmented the barrier injury. Conclusions These results suggest that lung bacterial infection causes cerebral microvascular leakage and neuroinflammation via a mechanism involving cytokine-induced BBB injury. ### Competing Interest Statement The authors have declared no competing interest.

Tools

"Here we incorporated inside EVs the endogenous retrovirus-like Arc protein capsids, stabilized by Arc 5'UTR RNA elements, to effectively load and deliver mRNAs. Produced from self-derived leukocytes, engineered retrotransposon Arc EVs (eraEVs) are immunologically inert with minimal clearance. Equipped with endothelial adhesion molecules from donor leukocytes, circulating eraEVs enter the brain enriching at neuro-inflammatory sites. "

#Preprint #Neuroscience #BloodBrainBarrier

biorxiv.org/content/10.1101/20

bioRxivEngineered retrovirus-like nanocarriers for messenger RNA delivery into neuronsSystemic delivery of mRNAs into disease neurons is first limited by the blood-brain-barrier (BBB). Leukocyte-derived extracellular vesicles (EVs) can cross the BBB at inflammatory sites, emerging as promising carriers to target the disease brain. However, efficient mRNA loading into EVs and their uptake by neurons remain challenges. Here we incorporated inside EVs the endogenous retrovirus-like Arc protein capsids, stabilized by Arc 5'UTR RNA elements, to effectively load and deliver mRNAs. Produced from self-derived leukocytes, engineered retrotransposon Arc EVs (eraEVs) are immunologically inert with minimal clearance. Equipped with endothelial adhesion molecules from donor leukocytes, circulating eraEVs enter the brain enriching at neuro-inflammatory sites. During self-assembly, Arc recruits enveloping proteins onto eraEVs further promoting neuronal uptake. Possessing high effectiveness like viral vectors and biocompatibility as natural vesicles, eraEV-nanocarriers can be produced from virtually all donor cell types, potentially leading to the development of future clinical therapies for a range of diseases. ### Competing Interest Statement Shaoyi Jiang, Wenchao Gu, Sijin Luozhong and Zhenfan Yuan are authors of a patent application related to this work (PCT/US2022/027568) filed by Cornell University. All other authors declare that they have no competing interests.

Insulin binding receptors are predominantly located in the microvessels within the blood-brain barrier. In patients with Alzheimer’s, the abundance of these receptors is decreased. This decrease could lead to the loss of insulin response in the Alzheimer’s brain.

#Neuroscience #Neurology #NeurologicalDiseases #NeurodegenerativeDiseases #Alzheimer #Brain #BBB #BloodBrainBarrier #Insulin #InsulinResistance

neurosciencenews.com/insulin-r