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Neurocognitive and psychiatric symptoms following infection with COVID-19: Evidence from laboratory and population studies

An evident lack of oxygen saturation in a brain region-specific to executive function and impulsive decision-making compared with those who had never been infected with the virus.

#Brian #CognitiveDisfunction #ReduceOxygen #SuperiorFrontalGyrus #Neurocognitive #psychiatric

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sciencedirect.com/science/arti

#Sargassum #Toxicity: Here's what you need to know

Experts predict it's likely here to stay

By Petar Denoble, MD, D.Sc., Mar 2, 2020

"If you’ve cruised the eastern #Caribbean or South #Florida recently, you probably caught a whiff of a rotten egg smell and noticed piles of floating brown seaweed hugging the shore. Far more than an eyesore, this Sargassum seaweed—and the gases it emits as it rots—has been proven to be hazardous to human health.

"Since 2011, massive Sargassum rafts have been washed up ashore along the eastern Caribbean, spoiling beaches, affecting near-coastal sea life, and causing health problems for beachgoers, boaters, and fishers. Recent satellite observations reveal an unprecedented belt of this brown macroalgae stretching from #WestAfrica to the Gulf of #Mexico—and experts predict that it’s likely there to stay. The problem has become such a menace south of the border that the Mexican Navy has been put in charge of dealing with it.

"Causes of the proliferation of #sargasso are thought to be the influx of fertilizers from the #Amazon and #Congo river basins; dust blown in from the #Sahara Desert carrying nitrogen, phosphorus, and #iron; and increased surface #temperature of the #ocean. In normal circumstances, the mass of sargasso may double in 11 days. With increasing temperatures, that growth gets boosted. The thickness of sargasso rafts gets larger, and the shores get hit by walls of sargasso mass.

"Under normal conditions, floating Sargassum is a thriving #ecosystem, providing a vital habitat and food source for many sea species—including turtles and mahi-mahi. But when it grows too thick, #dolphins and #turtles cannot break through it to the surface and often choke. And when sunlight cannot get through it to the bottom, bottom life gets damaged to the point of #extinction.

"Sargassum presents risks to human health as well. In the water, it’s harmless to humans, but the trouble begins once it lands on the beach and starts to decompose. The decomposition of beached sargasso begins 48 hours after washing up. It then releases hydrogen sulfide (H2S) gas and ammonia. H2S is a broad-spectrum poison that smells of rotten eggs.

"Breathing in these toxic gases may cause respiratory, skin and #neurocognitive symptoms in people that come in close contact with degrading sargasso. In 2018, in Guadeloupe and Martinique, there were 11,000 cases of suspected #poisoning reported. Patients complained of heart palpitations, shortness of breath, dizziness, vertigo, headache, and skin rashes."

#ClimateCrisis #ClimateChange #Pollution #Fertilizers

Read more:
danboater.org/travel-health-an

danboater.orgSargassum Toxicity: Here's what you need to knowMassive seaweed blooms causing health problems for boaters, fishermen, and beachgoers.

Long-term neurocognitive functioning of children treated with propranolol or atenolol for infantile hemangioma. OPEN ACCESS. Read it on: link.springer.com/article/10.1
#neurocognitive #children #propranolol #atenolol #hemangioma

SpringerLinkLong-term neurocognitive functioning of children treated with propranolol or atenolol for infantile hemangioma - European Journal of PediatricsThe purpose of this study was to compare long-term neurocognitive functioning (working memory, processing speed, and attention) between children who had been treated with either propranolol or atenolol for infantile hemangioma during infancy. All eligible children (n = 158) aged 6 years or older and treated with propranolol or atenolol as infants were invited to participate in this two-center cross-sectional study. The primary outcome was the Wechsler Intelligence Scale for Children-V Cognitive Proficiency Index (CPI), a measure of working memory, processing speed, and attention. Secondary outcomes were general intelligence, auditory, visuospatial, and narrative memory, as well as executive functioning and sleep. A total of 105 children, of whom 36 had been treated with propranolol (age 6.0–11.8 years, follow-up time 1.6–9.7 years, 19% male) and 69 had been treated with atenolol (age 6.9–9.7 years, follow-up time 4.5–8.4 years, 19% male), were analyzed. The CPI and other neurocognitive outcomes did not differ between the propranolol and atenolol groups and were in line with general population test norms. Post hoc analyses revealed lower CPI scores for males, both compared to participating females (10.3 IQ points, medium effect size) and compared to matched test norms (12.4 IQ points, medium effect size).Conclusions: Long-term neurocognitive functioning did not differ between children treated with propranolol and those treated with atenolol for IH. Overall, propranolol and atenolol appear to be safe treatments for IH regarding long-term neurocognitive functioning. The substantially lower CPI scores in males warrant further investigation.Trial registration: Netherlands Trial Register, NL7703 https://www.trialregister.nl/trial/7703 What is Known: • Infants with infantile hemangioma are effectively treated with propranolol or atenolol. • Parents and professionals are concerned about long-term neurocognitive effects. What is New: • No long-term (≥ 6 years) differences in neurocognitive functioning were found between children treated with propranolol or atenolol. • Males treated with beta-blockers had substantially lower IQ scores than treated females and males from the general population, which is a matter of concern and should be considered when evaluating the risk/benefit ratio in less severe forms of infantile hemangioma.