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CITO GreenhouseUnlocking the Secrets of the Mind and Body: A Journey into Interoception and Emotion<a href="https://mastodon.social/tags/MindBodyConnection" class="mention hashtag" rel="nofollow noopener" target="_blank">#MindBodyConnection</a> <a href="https://mastodon.social/tags/Interoception" class="mention hashtag" rel="nofollow noopener" target="_blank">#Interoception</a> <a href="https://mastodon.social/tags/BloodBrainBarrier" class="mention hashtag" rel="nofollow noopener" target="_blank">#BloodBrainBarrier</a> <a href="https://mastodon.social/tags/Emotions" class="mention hashtag" rel="nofollow noopener" target="_blank">#Emotions</a> <a href="https://mastodon.social/tags/Nociception" class="mention hashtag" rel="nofollow noopener" target="_blank">#Nociception</a> <a href="https://mastodon.social/tags/Antinociception" class="mention hashtag" rel="nofollow noopener" target="_blank">#Antinociception</a> <a href="https://mastodon.social/tags/SelfAwareness" class="mention hashtag" rel="nofollow noopener" target="_blank">#SelfAwareness</a> <a href="https://mastodon.social/tags/MentalHealth" class="mention hashtag" rel="nofollow noopener" target="_blank">#MentalHealth</a> <a href="https://mastodon.social/tags/Neuroscience" class="mention hashtag" rel="nofollow noopener" target="_blank">#Neuroscience</a> <a href="https://mastodon.social/tags/ExploreYourMind" class="mention hashtag" rel="nofollow noopener" target="_blank">#ExploreYourMind</a> <a href="https://mastodon.social/tags/BrainScience" class="mention hashtag" rel="nofollow noopener" target="_blank">#BrainScience</a> <a href="https://mastodon.social/tags/Mindfulness" class="mention hashtag" rel="nofollow noopener" target="_blank">#Mindfulness</a> <a href="https://mastodon.social/tags/EmotionalIntelligence" class="mention hashtag" rel="nofollow noopener" target="_blank">#EmotionalIntelligence</a> <a href="https://mastodon.social/tags/ScienceExplained" class="mention hashtag" rel="nofollow noopener" target="_blank">#ScienceExplained</a> <a href="https://mastodon.social/tags/GeomagneticField" class="mention hashtag" rel="nofollow noopener" target="_blank">#GeomagneticField</a><a href="https://youtube.com/shorts/bUaRkCnjZtg?feature=share" rel="nofollow noopener" translate="no" target="_blank">https://youtube.com/shorts/bUaRkCnjZtg?feature=share</a>

RhyothemisStudy offers a potential pathway for safer, non-addictive pain management<a href="https://www.news-medical.net/news/20241211/Study-offers-a-potential-pathway-for-safer-non-addictive-pain-management.aspx" rel="nofollow noopener" translate="no" target="_blank">https://www.news-medical.net/news/20241211/Study-offers-a-potential-pathway-for-safer-non-addictive-pain-management.aspx</a>"The study showed that when D₂O passed through the TRPV1 channel, it suppressed pain signal transmission and achieved effective analgesia."They studied both human cells in vitro and mice. This is good since another study found that D2O activated sweet taste receptors in humans, but not in mice - Sweet taste of heavy water <a href="https://www.nature.com/articles/s42003-021-01964-y" rel="nofollow noopener" translate="no" target="_blank">https://www.nature.com/articles/s42003-021-01964-y</a><a href="https://zeroes.ca/tags/HeavyWater" class="mention hashtag" rel="nofollow noopener" target="_blank">#HeavyWater</a> <a href="https://zeroes.ca/tags/D2O" class="mention hashtag" rel="nofollow noopener" target="_blank">#D2O</a> <a href="https://zeroes.ca/tags/solvents" class="mention hashtag" rel="nofollow noopener" target="_blank">#solvents</a> <a href="https://zeroes.ca/tags/TRPchannels" class="mention hashtag" rel="nofollow noopener" target="_blank">#TRPchannels</a> <a href="https://zeroes.ca/tags/SweetTasteReceptors" class="mention hashtag" rel="nofollow noopener" target="_blank">#SweetTasteReceptors</a> <a href="https://zeroes.ca/tags/Pain" class="mention hashtag" rel="nofollow noopener" target="_blank">#Pain</a> <a href="https://zeroes.ca/tags/nociception" class="mention hashtag" rel="nofollow noopener" target="_blank">#nociception</a> <a href="https://zeroes.ca/tags/TRPV1" class="mention hashtag" rel="nofollow noopener" target="_blank">#TRPV1</a> <a href="https://zeroes.ca/tags/neuroscience" class="mention hashtag" rel="nofollow noopener" target="_blank">#neuroscience</a> <a href="https://zeroes.ca/tags/biology" class="mention hashtag" rel="nofollow noopener" target="_blank">#biology</a> <a href="https://zeroes.ca/tags/MouseVsHuman" class="mention hashtag" rel="nofollow noopener" target="_blank">#MouseVsHuman</a>

Albert CardonaPhD Position in Neural Mechanisms of Nociceptive Perception and Modulation, in the lab of Carlotta Martelli, Johannes Gutenberg University Mainz, Germany.To apply, write to Martelli directly, see below:<a href="https://mathstodon.xyz/tags/PhDPosition" class="mention hashtag" rel="nofollow noopener" target="_blank">#PhDPosition</a> <a href="https://mathstodon.xyz/tags/neuroscience" class="mention hashtag" rel="nofollow noopener" target="_blank">#neuroscience</a> <a href="https://mathstodon.xyz/tags/Drosophila" class="mention hashtag" rel="nofollow noopener" target="_blank">#Drosophila</a> <a href="https://mathstodon.xyz/tags/nociception" class="mention hashtag" rel="nofollow noopener" target="_blank">#nociception</a>

RhyothemisUnderstanding the roots of chronic pain"A team of researchers led by Oscar Sánchez-Carranza in Professor Gary Lewin's lab at the Max Delbrück Center have identified a new function for the PIEZO2 protein -- in mediating chronic pain hypersensitivity. The research suggests a new target for analgesics and potentially explains why pain medications that target voltage gated sodium channels have been disappointing as clinical targets. "<a href="https://www.sciencedaily.com/releases/2024/07/240711111439.htm" rel="nofollow noopener" translate="no" target="_blank">https://www.sciencedaily.com/releases/2024/07/240711111439.htm</a><a href="https://zeroes.ca/tags/ChronicPain" class="mention hashtag" rel="nofollow noopener" target="_blank">#ChronicPain</a> <a href="https://zeroes.ca/tags/Piezo" class="mention hashtag" rel="nofollow noopener" target="_blank">#Piezo</a> <a href="https://zeroes.ca/tags/Piezo2" class="mention hashtag" rel="nofollow noopener" target="_blank">#Piezo2</a> <a href="https://zeroes.ca/tags/nociception" class="mention hashtag" rel="nofollow noopener" target="_blank">#nociception</a> <a href="https://zeroes.ca/tags/neuroscience" class="mention hashtag" rel="nofollow noopener" target="_blank">#neuroscience</a> <a href="https://zeroes.ca/tags/fibromyalgia" class="mention hashtag" rel="nofollow noopener" target="_blank">#fibromyalgia</a>

RhyothemisDr. Jarred Younger, PhD will be doing a weekly YouTube series on the latest research on pain and chronic illnesses such as fibromyalgia, ME/CFS, Long Covid and Gulf War Syndrome.🙂 ❤️ <a href="https://youtu.be/ZWWM6duVScE?si=VSatnYUYwMlxlUQX" rel="nofollow noopener" target="_blank">https://youtu.be/ZWWM6duVScE?si=VSatnYUYwMlxlUQX</a><a href="https://zeroes.ca/tags/fibromyalgia" class="mention hashtag" rel="nofollow noopener" target="_blank">#fibromyalgia</a> <a href="https://zeroes.ca/tags/ChronicPain" class="mention hashtag" rel="nofollow noopener" target="_blank">#ChronicPain</a> <a href="https://zeroes.ca/tags/MECFS" class="mention hashtag" rel="nofollow noopener" target="_blank">#MECFS</a> <a href="https://zeroes.ca/tags/LongCovid" class="mention hashtag" rel="nofollow noopener" target="_blank">#LongCovid</a> <a href="https://zeroes.ca/tags/GulfWarSyndrome" class="mention hashtag" rel="nofollow noopener" target="_blank">#GulfWarSyndrome</a> <a href="https://zeroes.ca/tags/GulfWarIllness" class="mention hashtag" rel="nofollow noopener" target="_blank">#GulfWarIllness</a> <a href="https://zeroes.ca/tags/MCAS" class="mention hashtag" rel="nofollow noopener" target="_blank">#MCAS</a> <a href="https://zeroes.ca/tags/AutoimmuneDiseases" class="mention hashtag" rel="nofollow noopener" target="_blank">#AutoimmuneDiseases</a> <a href="https://zeroes.ca/tags/neuroinflammation" class="mention hashtag" rel="nofollow noopener" target="_blank">#neuroinflammation</a> <a href="https://zeroes.ca/tags/nociception" class="mention hashtag" rel="nofollow noopener" target="_blank">#nociception</a> <a href="https://zeroes.ca/tags/Pain" class="mention hashtag" rel="nofollow noopener" target="_blank">#Pain</a> <a href="https://zeroes.ca/tags/inflammation" class="mention hashtag" rel="nofollow noopener" target="_blank">#inflammation</a>

RhyothemisErythromelalgia, pain, SCN9A / Nav1.7

Rhyothemison my to-read list:Pain-causing stinging nettle toxins target TMEM233 to modulate NaV1.7 function <a href="https://doi.org/10.1038/s41467-023-37963-2" rel="nofollow noopener" target="_blank">https://doi.org/10.1038/s41467-023-37963-2</a><a href="https://zeroes.ca/tags/Pain" class="mention hashtag" rel="nofollow noopener" target="_blank">#Pain</a> <a href="https://zeroes.ca/tags/gympietides" class="mention hashtag" rel="nofollow noopener" target="_blank">#gympietides</a> <a href="https://zeroes.ca/tags/nociception" class="mention hashtag" rel="nofollow noopener" target="_blank">#nociception</a> <a href="https://zeroes.ca/tags/SodiumChannels" class="mention hashtag" rel="nofollow noopener" target="_blank">#SodiumChannels</a> <a href="https://zeroes.ca/tags/TMEMchannels" class="mention hashtag" rel="nofollow noopener" target="_blank">#TMEMchannels</a> <a href="https://zeroes.ca/tags/NaturalProducts" class="mention hashtag" rel="nofollow noopener" target="_blank">#NaturalProducts</a>

RhyothemisAnimalogic put out an interesting Floralogic episode on the extreme, long-lasting pain caused by gympie gympie - a plant in the same family as stinging nettle - Gympie Gympie Is Doing Everything It Can To Ruin Your Life <a href="https://youtu.be/kIGQYE8pH_Y?si=4QN-DzBHdRg3OEen" rel="nofollow noopener" target="_blank">https://youtu.be/kIGQYE8pH_Y?si=4QN-DzBHdRg3OEen</a>It's an Australian plant, of course."Altering the activation threshold, combined with effects upon inactivation, likely leads to nociceptor activation and the sensation of pain, akin to biophysical changes observed in painful conditions associated with NaV1.7 [SCN9A] gain-of-function mutations such as inherited erythromelalgia (IEM) and paroxysmal extreme pain disorder (PEPD), respectively ... As the gympietides bear little similarity to any other known NaV modulators and display unusual effects particularly on NaV inactivation, it is difficult to predict possible binding sites at this point. However, based on activity of animal venom–derived toxins and the biophysics of NaV gating, the extracellular loops of the domain IV voltage sensor could be a possible binding site." <a href="https://doi.org/10.1126/sciadv.abb8828" rel="nofollow noopener" target="_blank">https://doi.org/10.1126/sciadv.abb8828</a><a href="https://zeroes.ca/tags/Pain" class="mention hashtag" rel="nofollow noopener" target="_blank">#Pain</a> <a href="https://zeroes.ca/tags/nociception" class="mention hashtag" rel="nofollow noopener" target="_blank">#nociception</a> <a href="https://zeroes.ca/tags/NaturalProducts" class="mention hashtag" rel="nofollow noopener" target="_blank">#NaturalProducts</a> <a href="https://zeroes.ca/tags/erythromelalgia" class="mention hashtag" rel="nofollow noopener" target="_blank">#erythromelalgia</a> <a href="https://zeroes.ca/tags/gympietides" class="mention hashtag" rel="nofollow noopener" target="_blank">#gympietides</a> <a href="https://zeroes.ca/tags/SodiumChannels" class="mention hashtag" rel="nofollow noopener" target="_blank">#SodiumChannels</a> <a href="https://zeroes.ca/tags/SCN9A" class="mention hashtag" rel="nofollow noopener" target="_blank">#SCN9A</a>

ℵ₀ 🏳️‍⚧️🏴‍☠️<a href="https://ntnuopen.ntnu.no/ntnu-xmlui/bitstream/handle/11250/2466061/Skorpen%2Bet%2Bal_2016_postscrpt.pdf?sequence=1" rel="nofollow noopener" translate="no" target="_blank">https://ntnuopen.ntnu.no/ntnu-xmlui/bitstream/handle/11250/2466061/Skorpen%2Bet%2Bal_2016_postscrpt.pdf?sequence=1</a> not a new paper. But I've been consistently surprised by how many doctors aren't even aware of this.(I got grilled about supposedly being an addict when I had almost no response to fentanyl. All I knew at the time was that some members of the family had abnormal pain & analgesic responses.)<a href="https://mastodon.social/tags/opioids" class="mention hashtag" rel="nofollow noopener" target="_blank">#opioids</a> <a href="https://mastodon.social/tags/deadsignaling" class="mention hashtag" rel="nofollow noopener" target="_blank">#deadsignaling</a> <a href="https://mastodon.social/tags/Arg181Cys" class="mention hashtag" rel="nofollow noopener" target="_blank">#Arg181Cys</a> <a href="https://mastodon.social/tags/painmanagement" class="mention hashtag" rel="nofollow noopener" target="_blank">#painmanagement</a> <a href="https://mastodon.social/tags/analgesia" class="mention hashtag" rel="nofollow noopener" target="_blank">#analgesia</a> <a href="https://mastodon.social/tags/nociception" class="mention hashtag" rel="nofollow noopener" target="_blank">#nociception</a> <a href="https://onlinelibrary.wiley.com/doi/10.1111/aas.12739" rel="nofollow noopener" translate="no" target="_blank">https://onlinelibrary.wiley.com/doi/10.1111/aas.12739</a>

Albert Cardona<a href="https://botsin.space/@flypapers" class="u-url mention" rel="nofollow noopener" target="_blank">@flypapers</a>Dissecting neural circuits for cold nociception in the <a href="https://mathstodon.xyz/tags/Drosophila" class="mention hashtag" rel="nofollow noopener" target="_blank">#Drosophila</a> larva, by Atit Patel in D. Cox lab: <a href="http://biorxiv.org/content/10.1101/2023.07.31.551339v1" rel="nofollow noopener" target="_blank">http://biorxiv.org/content/10.1101/2023.07.31.551339v1</a>Atit was a visitor of my former lab at <a href="https://mathstodon.xyz/tags/HHMIJanelia" class="mention hashtag" rel="nofollow noopener" target="_blank">#HHMIJanelia</a>. Took years to map the circuit, identify GAL4 lines, design and run behavioral assays and make sense of it all. Atit, a PhD student, did all the mapping and all the experiments and wrote most of the paper, and did a great job at it.For the insiders: this is about class III md (multidendritic) somatosensory neurons in the fly larva, and their synaptic connectivity, primarily onto various Basin neurons (Ohyama, Schneider-Mizell et al. 2015 <a href="https://www.nature.com/articles/nature14297" rel="nofollow noopener" target="_blank">https://www.nature.com/articles/nature14297</a> , Jovanic, Schneider-Mizell et al. et al. 2016 <a href="https://www.sciencedirect.com/science/article/pii/S0092867416312429" rel="nofollow noopener" target="_blank">https://www.sciencedirect.com/science/article/pii/S0092867416312429</a> ) but also other neurons such as Down-and-Back (Burgos et al. 2018 <a href="https://elifesciences.org/articles/26016" rel="nofollow noopener" target="_blank">https://elifesciences.org/articles/26016</a> ) and PNs of the class IV mds (Gerhard et al. 2017 <a href="https://elifesciences.org/articles/29089" rel="nofollow noopener" target="_blank">https://elifesciences.org/articles/29089</a> ).In other words, how somatosensoty neurons for cold nociception (class III mds) feed into the local circuits that process nociception (class IV mds) and mechanoreception (chordotonals).Note this work is unrelated to how the larva senses and responds to cold and warm stimuli (Hernandez-Nunez et al. 2021 <a href="https://www.science.org/doi/abs/10.1126/sciadv.abg6707" rel="nofollow noopener" target="_blank">https://www.science.org/doi/abs/10.1126/sciadv.abg6707</a> )<a href="https://mathstodon.xyz/tags/neuroscience" class="mention hashtag" rel="nofollow noopener" target="_blank">#neuroscience</a> <a href="https://mathstodon.xyz/tags/nociception" class="mention hashtag" rel="nofollow noopener" target="_blank">#nociception</a> <a href="https://mathstodon.xyz/tags/connectomics" class="mention hashtag" rel="nofollow noopener" target="_blank">#connectomics</a>

Dan TraceyMy <a href="https://drosophila.social/tags/introduction" class="mention hashtag" rel="nofollow noopener" target="_blank">#introduction</a>. I run a small not-for profit research organization that depends on writing grants and publishing papers for its success. I guess you call that a <a href="https://drosophila.social/tags/laboratory" class="mention hashtag" rel="nofollow noopener" target="_blank">#laboratory</a> and I’m the PI. We study somatosensation, primarily in the <a href="https://drosophila.social/tags/drosophila" class="mention hashtag" rel="nofollow noopener" target="_blank">#drosophila</a> larva. Our main focus has been on pain and <a href="https://drosophila.social/tags/nociception" class="mention hashtag" rel="nofollow noopener" target="_blank">#nociception</a>. We also study parasitoid wasps and larval defenses against them. I’m also into <a href="https://drosophila.social/tags/cycling" class="mention hashtag" rel="nofollow noopener" target="_blank">#cycling</a> and <a href="https://drosophila.social/tags/sailing" class="mention hashtag" rel="nofollow noopener" target="_blank">#sailing</a> and I once did a <a href="https://drosophila.social/tags/seabattical" class="mention hashtag" rel="nofollow noopener" target="_blank">#seabattical</a> in the <a href="https://drosophila.social/tags/Caribbean" class="mention hashtag" rel="nofollow noopener" target="_blank">#Caribbean</a>. Current post is at <a href="https://drosophila.social/tags/IndianaUniversity" class="mention hashtag" rel="nofollow noopener" target="_blank">#IndianaUniversity</a>.

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