“By analyzing a longitudinal cohort of individuals infected with #SARSCoV2 during the first wave of #pandemic infections, Cai et al. found that subsequent #vaccination against #COVID19 enhanced the frequency and functional qualities of #spike-specific #Tcells. Despite up-regulation of inhibitory receptors, spike-specific T cells produced more effector #cytokines and cytotoxic molecules after #vaccination” https://mstdn.social/@erictopol/111546489766413387
Doesn't matter much. MHC-I is functionally kaput. It doesn't matter how diligently an archer trains, they'll never win a contest without targets.