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Dining & CookingMediterranean diet lowers COVID-19 risk, but its effect on symptoms and severity remains uncertain <a href="https://www.diningandcooking.com/1970743/mediterranean-diet-lowers-covid-19-risk-but-its-effect-on-symptoms-and-severity-remains-uncertain/" rel="nofollow noopener noreferrer" target="_blank">https://www.diningandcooking.com/1970743/mediterranean-diet-lowers-covid-19-risk-but-its-effect-on-symptoms-and-severity-remains-uncertain/</a> #<a href="https://vive.im/tags/COVID19" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#COVID19</a> #<a href="https://vive.im/tags/inflammation" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#inflammation</a> <a href="https://vive.im/tags/coronavirus" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#coronavirus</a> <a href="https://vive.im/tags/cough" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#cough</a> <a href="https://vive.im/tags/Cytokine" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Cytokine</a> <a href="https://vive.im/tags/Cytokines" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Cytokines</a> <a href="https://vive.im/tags/diarrhea" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#diarrhea</a> <a href="https://vive.im/tags/diet" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#diet</a> <a href="https://vive.im/tags/Fever" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Fever</a> <a href="https://vive.im/tags/Fish" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Fish</a> <a href="https://vive.im/tags/food" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#food</a> <a href="https://vive.im/tags/Frequency" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Frequency</a> <a href="https://vive.im/tags/Immunomodulatory" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Immunomodulatory</a> <a href="https://vive.im/tags/Mediterranean" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Mediterranean</a> <a href="https://vive.im/tags/MediterraneanDiet" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#MediterraneanDiet</a> <a href="https://vive.im/tags/Mortality" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Mortality</a> <a href="https://vive.im/tags/NasalCongestion" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#NasalCongestion</a> <a href="https://vive.im/tags/nausea" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#nausea</a> <a href="https://vive.im/tags/OliveOil" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#OliveOil</a> <a href="https://vive.im/tags/oxygen" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#oxygen</a> <a href="https://vive.im/tags/pandemic" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#pandemic</a> <a href="https://vive.im/tags/SARS" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#SARS</a> <a href="https://vive.im/tags/SARSCoV2" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#SARSCoV2</a> <a href="https://vive.im/tags/SoreThroat" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#SoreThroat</a> <a href="https://vive.im/tags/Throat" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Throat</a> <a href="https://vive.im/tags/VitaminC" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#VitaminC</a>

Dining & CookingGroundbreaking research reveals key gut cells involved in food tolerance <a href="https://www.diningandcooking.com/1862737/groundbreaking-research-reveals-key-gut-cells-involved-in-food-tolerance/" rel="nofollow noopener noreferrer" target="_blank">https://www.diningandcooking.com/1862737/groundbreaking-research-reveals-key-gut-cells-involved-in-food-tolerance/</a> <a href="https://vive.im/tags/Antigen" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Antigen</a> <a href="https://vive.im/tags/bacteria" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#bacteria</a> <a href="https://vive.im/tags/cell" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#cell</a> <a href="https://vive.im/tags/Cytokines" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Cytokines</a> <a href="https://vive.im/tags/food" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#food</a> <a href="https://vive.im/tags/FoodIntolerance" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#FoodIntolerance</a> <a href="https://vive.im/tags/ImmuneResponse" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#ImmuneResponse</a> <a href="https://vive.im/tags/ImmuneSystem" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#ImmuneSystem</a> <a href="https://vive.im/tags/Immunology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Immunology</a> <a href="https://vive.im/tags/Laboratory" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Laboratory</a> <a href="https://vive.im/tags/protein" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#protein</a> <a href="https://vive.im/tags/Research" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Research</a>

PsyPostBrain inflammation may be the reason behind muscle fatigue after infection and injury <a href="https://www.psypost.org/brain-inflammation-may-be-the-reason-behind-muscle-fatigue-after-infection-and-injury/?utm_source=dlvr.it&utm_medium=mastodon" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://www.psypost.org/brain-inflammation-may-be-the-reason-behind-muscle-fatigue-after-infection-and-injury/?utm_source=dlvr.it&utm_medium=mastodon</a> <a href="https://mstdn.social/tags/Neuroinflammation" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Neuroinflammation</a> <a href="https://mstdn.social/tags/MuscleFatigue" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#MuscleFatigue</a> <a href="https://mstdn.social/tags/BrainHealth" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#BrainHealth</a> <a href="https://mstdn.social/tags/ChronicDisease" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#ChronicDisease</a> <a href="https://mstdn.social/tags/Cytokines" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Cytokines</a>

Giuseppe MichieliImmunological <a href="https://mstdn.science/tags/findings" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#findings</a> of West Caucasian <a href="https://mstdn.science/tags/bat" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#bat</a> <a href="https://mstdn.science/tags/virus" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#virus</a> in an accidental host <a href="http://biorxiv.org/cgi/content/short/2024.09.12.612599v1?rss=1" rel="nofollow noopener noreferrer" translate="no" target="_blank">http://biorxiv.org/cgi/content/short/2024.09.12.612599v1?rss=1</a> In <a href="https://mstdn.science/tags/hamsters" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#hamsters</a>, <a href="https://mstdn.science/tags/WCBV" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#WCBV</a> was highly pathogenic, determining 100% <a href="https://mstdn.science/tags/lethality" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#lethality</a> and mild <a href="https://mstdn.science/tags/encephalitis" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#encephalitis</a>. In comparison with Duvenhage virus (DUVV) and <a href="https://mstdn.science/tags/RABV" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#RABV</a>, we found that WCBV displayed an intermediate ability to promote cellular antiviral response, produce pro-inflammatory <a href="https://mstdn.science/tags/cytokines" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#cytokines</a>, recruit and activate <a href="https://mstdn.science/tags/lymphocytes" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#lymphocytes</a> in the hamsters central nervous system.

Giuseppe MichieliAn ex vivo <a href="https://mstdn.science/tags/human" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#human</a> precision-cut <a href="https://mstdn.science/tags/lung" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#lung</a> slice <a href="https://mstdn.science/tags/platform" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#platform</a> provides insight into <a href="https://mstdn.science/tags/SARS" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#SARS</a>-CoV-2 <a href="https://mstdn.science/tags/pathogenesis" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#pathogenesis</a> and <a href="https://mstdn.science/tags/antiviral" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#antiviral</a> drug <a href="https://mstdn.science/tags/efficacy" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#efficacy</a>, J Virol.: <a href="https://journals.asm.org/doi/full/10.1128/jvi.00794-24?af=R" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://journals.asm.org/doi/full/10.1128/jvi.00794-24?af=R</a>We identified early induction of specific <a href="https://mstdn.science/tags/cytokines" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#cytokines</a>, especially IP-10 and IL-8, as potential predictors for severe <a href="https://mstdn.science/tags/COVID19" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#COVID19</a>, & uncovered a hitherto unrecognized phenomenon that while infectious virus disappears at late times of infection, viral <a href="https://mstdn.science/tags/RNA" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#RNA</a> persists and lung histopathology commences.

Alan LewisA CAUSE OF INFLAMMATORY BOWEL DISEASE FOUND Mastodon PostBBCMajor cause of inflammatory bowel disease found 1 day agoJames Gallagher,Health and science correspondent<a href="https://www.bbc.com/news/articles/c1wwdd6v2wjo" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://www.bbc.com/news/articles/c1wwdd6v2wjo</a>This is very serious business. Going on memory, my barber needed surgery because of long-term use of medication for Crohn's disease. He died of some complication from the surgery. He had the surgery, he seemed to be recovering well, and then, quite suddenly, he was gone.:<a href="https://c.im/tags/crohnsandcolitis" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#crohnsandcolitis</a> <a href="https://c.im/tags/crohnsdisease" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#crohnsdisease</a> <a href="https://c.im/tags/cytokines" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#cytokines</a> <a href="https://c.im/tags/franciscrickinstitute" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#franciscrickinstitute</a> <a href="https://c.im/tags/inflammatoryboweldisease" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#inflammatoryboweldisease</a> <a href="https://c.im/tags/inflammatorycolitis" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#inflammatorycolitis</a> <a href="https://c.im/tags/jamesgallagher" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#jamesgallagher</a> <a href="https://c.im/tags/jameslee" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#jameslee</a> <a href="https://c.im/tags/macrophages" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#macrophages</a> <a href="https://c.im/tags/medicalscience" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#medicalscience</a> <a href="https://c.im/tags/medicalsciencenews" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#medicalsciencenews</a> <a href="https://c.im/tags/ruthwakeman" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#ruthwakeman</a> <a href="https://c.im/tags/sciencenews" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#sciencenews</a> <a href="https://c.im/tags/ulcerativecolitis" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#ulcerativecolitis</a> <a href="https://c.im/tags/universitycollegelondon" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#universitycollegelondon</a> :::

Scientific Frontline<a href="https://mastodon.social/tags/Australian" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Australian</a> researchers have found that a family of <a href="https://mastodon.social/tags/proinflammatory" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#proinflammatory</a> <a href="https://mastodon.social/tags/molecules" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#molecules</a> called beta common <a href="https://mastodon.social/tags/cytokines" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#cytokines</a> control inflammation and scarring of the airways (fibrosis) in severe and steroid-resistant <a href="https://mastodon.social/tags/asthma" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#asthma</a>. <a href="https://mastodon.social/tags/Medical" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Medical</a> <a href="https://mastodon.social/tags/sflorg" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#sflorg</a> <a href="https://www.sflorg.com/2024/02/med02252402.html" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://www.sflorg.com/2024/02/med02252402.html</a>

Monika WolkersPlease find below our most recent pre-print. We studied the role of the RNA binding protein ZFP36L2 in effector T cells and found how it regulated the production of IFNgamma in late T cell responses and continuous activation with tumor cells (in vitro/in vivo). Happy reading!<a href="https://www.biorxiv.org/content/10.1101/2024.02.09.579641v1.article-metrics" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://www.biorxiv.org/content/10.1101/2024.02.09.579641v1.article-metrics</a><a href="https://mstdn.science/tags/Tcells" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Tcells</a> <a href="https://mstdn.science/tags/immunology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#immunology</a> <a href="https://mstdn.science/tags/tumor" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#tumor</a> <a href="https://mstdn.science/tags/rna_binding_proteins" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#rna_binding_proteins</a> <a href="https://mstdn.science/tags/cytokines" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#cytokines</a>

Auscandoc“By analyzing a longitudinal cohort of individuals infected with <a href="https://med-mastodon.com/tags/SARSCoV2" class="mention hashtag" rel="tag">#SARSCoV2</a> during the first wave of <a href="https://med-mastodon.com/tags/pandemic" class="mention hashtag" rel="tag">#pandemic</a> infections, Cai et al. found that subsequent <a href="https://med-mastodon.com/tags/vaccination" class="mention hashtag" rel="tag">#vaccination</a> against <a href="https://med-mastodon.com/tags/COVID19" class="mention hashtag" rel="tag">#COVID19</a> enhanced the frequency and functional qualities of <a href="https://med-mastodon.com/tags/spike" class="mention hashtag" rel="tag">#spike</a>-specific <a href="https://med-mastodon.com/tags/Tcells" class="mention hashtag" rel="tag">#Tcells</a>. Despite up-regulation of inhibitory receptors, spike-specific T cells produced more effector <a href="https://med-mastodon.com/tags/cytokines" class="mention hashtag" rel="tag">#cytokines</a> and cytotoxic molecules after <a href="https://med-mastodon.com/tags/vaccination" class="mention hashtag" rel="tag">#vaccination</a>” <a href="https://mstdn.social/@erictopol/111546489766413387" target="_blank" rel="nofollow noopener noreferrer" translate="no">https://mstdn.social/@erictopol/111546489766413387</a>

halama_immuno<a href="https://med-mastodon.com/@gpollara" class="u-url mention" rel="nofollow noopener noreferrer" target="_blank">@gpollara</a> <a href="https://qoto.org/@cyrilpedia" class="u-url mention" rel="nofollow noopener noreferrer" target="_blank">@cyrilpedia</a> Absolutely true...I have been pondering the role of this kolecule also quite often...and in the context of different inflammatory contexts it seems to play different roles... <a href="https://mstdn.science/tags/inflammation" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#inflammation</a> <a href="https://mstdn.science/tags/cytokines" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#cytokines</a> <a href="https://mstdn.science/tags/immunology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#immunology</a>

halama_immuno<a href="https://mstdn.science/tags/innateimmunity" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#innateimmunity</a> in action: <a href="https://mstdn.science/tags/immunotherapy" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#immunotherapy</a> against <a href="https://mstdn.science/tags/breastcancer" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#breastcancer</a> with TLR3 ligand and interferon alpha. Only six patients in this <a href="https://mstdn.science/tags/trial" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#trial</a> , but biopsy analyses show improved <a href="https://mstdn.science/tags/inmuneinfiltration" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#inmuneinfiltration</a> with <a href="https://mstdn.science/tags/TILs" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#TILs</a> and is linked to clinical observations. <a href="https://mstdn.science/tags/interferon" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#interferon</a> <a href="https://mstdn.science/tags/cytokines" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#cytokines</a> <a href="https://mstdn.science/tags/immunology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#immunology</a> <a href="https://mstdn.science/tags/macrophages" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#macrophages</a> <a href="https://mstdn.social/@chfloudas" class="u-url mention" rel="nofollow noopener noreferrer" target="_blank">@chfloudas</a> <a href="https://jitc.bmj.com/content/11/11/e007381" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://jitc.bmj.com/content/11/11/e007381</a>

halama_immuno<a href="https://med-mastodon.com/@gpollara" class="u-url mention" rel="nofollow noopener noreferrer" target="_blank">@gpollara</a> <a href="https://qoto.org/@cyrilpedia" class="u-url mention" rel="nofollow noopener noreferrer" target="_blank">@cyrilpedia</a> Well...trials so far have shown: big toxicity, limited clinical effects and some suggest an increase in inhibitory Tregs...why there are modified IL-2 therapies around to limit toxic and Treg induction...to be continued <a href="https://mstdn.science/tags/Immunotherapy" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Immunotherapy</a> <a href="https://mstdn.science/tags/immunology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#immunology</a> <a href="https://mstdn.science/tags/cytokines" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#cytokines</a>

The EMBO JournalHow does signaling via extracellular <a href="https://sciencemastodon.com/tags/nucleotides" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#nucleotides</a> contribute to innate immunity? Systematic <a href="https://sciencemastodon.com/tags/P2Y" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#P2Y</a> receptor survey in human <a href="https://sciencemastodon.com/tags/macrophages" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#macrophages</a> shows some control <a href="https://sciencemastodon.com/tags/inflammatory" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#inflammatory</a> <a href="https://sciencemastodon.com/tags/cytokines" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#cytokines</a>, others viral replication, and <a href="https://sciencemastodon.com/tags/P2Y11" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#P2Y11</a> uniquely combining both rolesLine Lykke Andersen et al Andreas Pichlmair <a href="https://www.embopress.org/doi/full/10.15252/embj.2022113279" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://www.embopress.org/doi/full/10.15252/embj.2022113279</a>

halama_immuno<a href="https://med-mastodon.com/@gpollara" class="u-url mention" rel="nofollow noopener noreferrer" target="_blank">@gpollara</a> Is there a comprehensive resource that investigates the interferon signalling "landscape", also in conjunction with other microenvironmental pathways like cGAS or STING etc.? <a href="https://mstdn.science/tags/cytokines" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#cytokines</a> <a href="https://mstdn.science/tags/networks" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#networks</a> <a href="https://mstdn.science/tags/CellSignaling" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#CellSignaling</a> <a href="https://mstdn.science/tags/immunology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#immunology</a> <a href="https://mstdn.science/tags/infection" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#infection</a> <a href="https://mstdn.science/tags/immunotherapy" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#immunotherapy</a>

PKPs Powerfromspace1By @harryspoelstra COVID-19 promotes endothelial dysfunction and thrombogenicity: Role of pro-inflammatory <a href="https://mstdn.social/tags/cytokines" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#cytokines</a>/SGLT2 pro-oxidant pathway❗Finally we’re getting closer to understanding the underlying mechanisms, maybe even finding therapeutic possibilities, that of course need further research!➡️"In <a href="https://mstdn.social/tags/COVID19" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#COVID19</a> patients, pro-inflammatory cytokines( f IL-1β, IL-6, TNF-α, MCP-1 and sICAM-1) induced a redox-sensitive up regulation of… ➡️<a href="Http://pubmed.ncbi.nlm.nih.gov/37797691/" rel="nofollow noopener noreferrer" translate="no" target="_blank">Http://pubmed.ncbi.nlm.nih.gov/37797691/</a>

PLOS BiologyHow does breast cancer recur after dormancy? @TTCooperPhD & @DrPostovit explore a <a href="https://fediscience.org/tags/PLOSBiology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#PLOSBiology</a> study showing that <a href="https://fediscience.org/tags/docetaxel" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#docetaxel</a>-induced injury of <a href="https://fediscience.org/tags/tumor" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#tumor</a> stromal cells stimulates release of <a href="https://fediscience.org/tags/cytokines" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#cytokines</a> that support dormancy escape of <a href="https://fediscience.org/tags/BreastCancer" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#BreastCancer</a> cells. Paper: <a href="https://plos.io/3RjsGoQ" rel="nofollow noopener noreferrer" target="_blank">https://plos.io/3RjsGoQ</a> Primer: <a href="https://plos.io/457Epuh" rel="nofollow noopener noreferrer" target="_blank">https://plos.io/457Epuh</a>

Auscandoc<a href="https://med-mastodon.com/tags/Vaccinated" class="mention hashtag" rel="tag">#Vaccinated</a> people have lower levels of <a href="https://med-mastodon.com/tags/inflammatory" class="mention hashtag" rel="tag">#inflammatory</a> markers after <a href="https://med-mastodon.com/tags/COVID19" class="mention hashtag" rel="tag">#COVID19</a> infection <a href="https://www.news-medical.net/news/20230808/Vaccinated-people-have-lower-levels-of-inflammatory-markers-after-COVID-19-infection.aspx" target="_blank" rel="nofollow noopener noreferrer" translate="no">https://www.news-medical.net/news/20230808/Vaccinated-people-have-lower-levels-of-inflammatory-markers-after-COVID-19-infection.aspx</a> “The study published today in The <a href="https://med-mastodon.com/tags/Lancet" class="mention hashtag" rel="tag">#Lancet</a> Microbe found among individuals recently infected with <a href="https://med-mastodon.com/tags/SARSCoV2" class="mention hashtag" rel="tag">#SARSCoV2</a>, those who were fully vaccinated had lower concentrations of almost all <a href="https://med-mastodon.com/tags/inflammation" class="mention hashtag" rel="tag">#inflammation</a> markers (<a href="https://med-mastodon.com/tags/cytokines" class="mention hashtag" rel="tag">#cytokines</a> and <a href="https://med-mastodon.com/tags/chemokines" class="mention hashtag" rel="tag">#chemokines</a>) than those who were <a href="https://med-mastodon.com/tags/unvaccinated" class="mention hashtag" rel="tag">#unvaccinated</a> in the short-term and long-term after symptomatic SARS-CoV-2 infection.”

Arjan Boltjes<a href="https://med-mastodon.com/@gpollara" class="u-url mention" rel="nofollow noopener noreferrer" target="_blank">@gpollara</a> <a href="https://mstdn.science/@JExpMed" class="u-url mention" rel="nofollow noopener noreferrer" target="_blank">@JExpMed</a> Intriguing. In an earlier postdoc position I had a look at <a href="https://mastodon.social/tags/DendriticCells" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#DendriticCells</a>, and especially the <a href="https://mastodon.social/tags/cDC1" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#cDC1</a> were abundant, but seemed to be just sitting in the inflammatory environment, doing little. One of the very abundant cytokines: <a href="https://mastodon.social/tags/IL6" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#IL6</a>We also looked at the effect of that and other <a href="https://mastodon.social/tags/cytokines" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#cytokines</a>, but mostly on <a href="https://mastodon.social/tags/Tcells" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Tcells</a>, among others due to the low abundance of cDC1 in HC blood to be able to do many in vitro experiments.

halama_immuno<a href="https://mstdn.science/tags/cytokines" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#cytokines</a> as <a href="https://mstdn.science/tags/biomarkers" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#biomarkers</a> for therapeutic success in <a href="https://mstdn.science/tags/NSCLC" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#NSCLC</a> <a href="https://mstdn.science/tags/nsclctrial" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#nsclctrial</a> <a href="https://mstdn.science/tags/Immunotherapy" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Immunotherapy</a> <a href="https://mstdn.science/tags/pd1" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#pd1</a> <a href="https://mstdn.science/tags/pdl1" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#pdl1</a> utilizing <a href="https://mstdn.science/tags/MachineLearming" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#MachineLearming</a> , link to downloadable PDF <a href="https://bit.ly/3NTxfTt" rel="nofollow noopener noreferrer" target="_blank">https://bit.ly/3NTxfTt</a>

Chuck DarwinHealing from the hypothalamus –To survive an infection, our body must recognize and respond to invading pathogens. This is the job of the immune system. When the first few immune cells encounter a pathogen, especially one that they haven’t seen before, they start releasing <a href="https://c.im/tags/cytokines" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#cytokines</a> like <a href="https://c.im/tags/interleukin" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#interleukin</a>-1 (IL-1). These cytokines are the messengers of the immune system. They race through the body via the bloodstream, summoning immune troops to push back the invading pathogen.When they reach the central nervous system, cytokines must cross the <a href="https://c.im/tags/blood" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#blood</a>-<a href="https://c.im/tags/brain" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#brain</a> <a href="https://c.im/tags/barrier" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#barrier</a> to alert and recruit a brain response. The blood-brain barrier has only a handful of entry points, called <a href="https://c.im/tags/circumventricular" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#circumventricular</a> <a href="https://c.im/tags/organs" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#organs</a>, where traffic can pass between the central nervous system and the bloodstream with relative ease. One of these sits at the base of the <a href="https://c.im/tags/hypothalamus" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#hypothalamus</a> in a structure called the <a href="https://c.im/tags/Vascular" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Vascular</a> <a href="https://c.im/tags/Organ" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Organ</a> of the <a href="https://c.im/tags/Lamina" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Lamina</a> <a href="https://c.im/tags/Terminalis" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Terminalis</a> (VOLT for short). The <a href="https://c.im/tags/VOLT" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#VOLT</a> is filled with receptors that detect IL-1 and other cytokines. That, along with its proximity to our <a href="https://c.im/tags/homeostat" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#homeostat</a> hypothalamus, means it’s positioned perfectly to sense an ongoing immune response and initiate our brain and body’s many defensive tactics. After receiving signals from the VOLT, the hypothalamus creates many of the familiar experiences of sickness<a href="https://pennneuroknow.com/2023/06/27/healing-from-the-hypothalamus/" rel="nofollow noopener noreferrer" target="_blank">https://pennneuroknow.com/2023/06/27/healing-from-the-hypothalamus/</a>

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