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#tvns

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I think I have enough data now to say that my #tVNS machine helps quite a lot with nausea, just in case anyone was looking for something new to try.
Disclaimer: my nausea is triggered by hormonal fluctuations, dunno how well it works work for nausea triggered by other things.
Extra disclaimer: I use a generic TENS/EMS machine rather than a specific tVNS machine, because it was cheaper 🤷🏼‍♀️

I've had to find a different way to fit my #tVNS in during the school holidays, so instead of doing it during my first big morning rest, I'm doing it during my first coffee of the day. Working well so far 🤞🏻
I really wish someone would do some research looking at tVNS for #POTS patients, comparing doing it at rest vs doing it while active. Would love to know if one option is better than the other 🤔

New preprint! We observed a nonlinear relationship between pupil dilation and the intensity of transcutaneous auricular #vagus nerve stimulation (#taVNS) in adult humans. We discuss the potential role of stimulation parameterization in using #pupillometry as biomarker of taVNS’s neuromodulatory effects.

#tVNS #neuromodulation #brainstimulation #gamms

biorxiv.org/content/10.1101/20

bioRxiv · 300 Hz transcutaneous auricular vagus nerve stimulation (taVNS) impacts pupil size nonlinearly as a function of intensityTranscutaneous auricular vagus nerve stimulation (taVNS) is a neuromodulatory technique that may have numerous potential health and human performance benefits. However, optimal stimulation parameters for maximizing taVNS efficacy are unknown. Progress is impeded by disagreement on the identification of a biomarker that reliably indexes activation of neuromodulatory systems targeted by taVNS, including the locus coeruleus-norepinephrine (LC-NE) system. Pupil size varies with LC-NE activity and is one potential taVNS biomarker that has shown inconsistent sensitivity to taVNS in prior studies. The present study examined the relationship between pupil size and taVNS using stimulation parameters that have shown promising behavioral effects in prior studies but have received comparatively little attention. Participants received 30-second trains of 50 μs taVNS pulses delivered below perceptual threshold at 300 Hz to the left external acoustic meatus (EAM) while pupil size was recorded during a pupillary light reflex task. Analysis of pupil size using generalized additive mixed modelling (GAMM) revealed a nonlinear relationship between taVNS intensity and pupil diameter. Active taVNS increased pupil size during stimulation for participants who received taVNS between 2 and approximately 4.8 mA, but not for participants who received higher intensity taVNS (up to 8.1 mA). In addition, taVNS effects persisted in subsequent blocks, mitigating decreases in pupil size over the course of the task. These findings suggest 300 Hz taVNS activates the LC-NE system when applied to the EAM, but its effects may be counteracted at higher intensities. ### Competing Interest Statement The authors have declared no competing interest.

Since most of us are #newhere, I want to talk a bit about what we are working on.

We recently showed that non-invasive #stimulation of vagal afferents using #tvns increases stomach-brain coupling (led by @revivaciously).

brainstimjrnl.com/article/S193

Next, we will test whether this also works in patients with #depression. Our hope is that we can improve somatic symptoms, which are not very responsive to conventional treatments.

#introduction Hi all. I’m a PI in the Audiology and Speech Pathology Center at Walter Reed National Military Medical Center. (Views are my own.)
I use a variety of methods to study the auditory, linguistic, and cognitive factors that contribute to effortful listening in diverse populations.
#auditory #hearing #linguistics #language #cognition #aging #ListeningEffort #speech #SpeechInNoise #pupillometry #fMRI #EEG #MEG #tVNS #neuroscience #neuro

#introduction
I'm an #earlycareer #sleep #neuroscientist aiming to understand why everything looks so much better in the morning.

Currently a #postdoc with Matt Walker at #UC #berkeley working on the intersection of sleep with #aging & #mentalhealth.

Finished my #phd a year ago in #Faculty of #Medicine, #Tel-Aviv #university with Yuval Nir.
Worked on #sensory #perception during sleep, sleep & #memory and how it goes wrong in #Alzheimer.
#tau #amyloid #tvns #EEG, #psg #fMRI, #python #MNE