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#tissueengineering

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Dr. Marie McNeely

Everyone loves the story of an underdog, and Dr. Luiz Bertassoni shared part of his remarkable story of perseverance in our latest podcast episode! He covered his academic training spanning 3 continents, his research applying engineering tools to biology to study cancer and regenerative medicine, his favorite scientific travels, building an innovative new research center, his love of surfing and music, and more.

peoplebehindthescience.com/dr-

This episode was made possible with support from Innovative Research.

#OHSU#tissueengineering#engineering
halama_immuno

Another addition to the toolbox: between #organoids and #explantmodels are the #epitheloids ...self maintaining over a long time, these models recapitulate epithelial structures. #ModelSystem #models #bioengineering #tissue #tissueengineering @schumacher @gpollara
biorxiv.org/content/10.1101/20

bioRxivEpithelioids: Self-sustaining 3D epithelial cultures to study long-term processesStudying long-term biological processes such as the colonization of aging epithelia by somatic mutant clones has been slowed by the lack of suitable culture systems. Here we describe epithelioids, a facile, cost-effective method of culturing multiple mouse and human epithelia. Esophageal epithelioids self-maintain without passaging for at least a year, recapitulating the 3D structure, cell dynamics, transcriptome, and genomic stability of the esophagus. Live imaging over 5 months showed epithelioids replicate in vivo cell dynamics. Epithelioids enable the study of cell competition and mutant selection in 3D epithelia, and how anti-cancer treatments modulate the competition between transformed and wild type cells. Epithelioids are a novel method with a wide range of applications in epithelial tissues, particularly the study of long term processes, that cannot be accessed using other culture models. ### Competing Interest Statement The authors have declared no competing interest.
Christian Tidona

Did you know that during #embryo development, migrating #monocytes deposit tracks of pro-angiogenic #migrasomes guiding the formation of blood vessels?

In this interesting manuscript published in Nature Cell Biology, researchers at Tsinghua University in Beijing studied this phenomenon in the chorioallantoic membrane of chick embryos: nature.com/articles/s41556-022

This could have implications in organotypic #tissueengineering and provide new ways how to inhibit #angiogenesis in solid #tumors.

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