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#gutbacteria

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Lolamicin: The Selective antibiotic against Gram-negative infections that spares gut microbiome  
Current antibiotics used in clinical practice, in addition to neutralising target pathogens also harm healthy bacteria in the gut............
#Antibiotics #Gramnegativebacteria #GutBacteria #Lolamicin #microbiome #NewsinBrief
SCIEU Team

scientificeuropean.co.uk/medic

"Taken together, our study demonstrates that members of the Bacteroidota phylum contribute to AD pathogenesis by suppressing microglia phagocytic function, which leads to impaired Aβ clearance and accumulation of amyloid plaques."

Bacteroidota inhibit microglia clearance of amyloid-beta and promote plaque deposition in Alzheimer’s disease mouse models
Wasén et al., Nature Communications 2024
doi.org/10.1038/s41467-024-476

Gut bacteria break down cholesterol — hinting at probiotic treatments

Species in the human microbiome have enzymes that can metabolize a potentially dangerous lipid.

nature.com/articles/d41586-024

I follow gut bacteria because of the relation with chronic brain disease like dementia, immune system in general, susceptibility to addiction, .. and possibly helping to cure LongCovid (section on long covid there: erictopol.substack.com/p/a-cov )

www.nature.comGut bacteria break down cholesterol — hinting at probiotic treatmentsSpecies in the human microbiome have enzymes that can metabolize a potentially dangerous lipid.
EurekAlert!Scientists link certain gut bacteria to lower heart disease risk<p>Changes in the gut microbiome have been implicated in a range of diseases including type 2 diabetes, obesity, and inflammatory bowel disease. Now, a team of researchers at the Broad Institute of MIT and Harvard along with Massachusetts General Hospital has found that microbes in the gut may affect cardiovascular disease as well. In a study published in <em>Cell</em>, the team has identified specific species of bacteria that consume cholesterol in the gut and may help lower cholesterol and heart disease risk in people.</p> <p>Members of <a href="https://www.broadinstitute.org/node/4721"><u>Ramnik Xavier’s</u></a> lab, Broad’s <a href="https://www.broadinstitute.org/node/8539"><u>Metabolomics Platform</u></a>, and collaborators analyzed metabolites and microbial genomes from more than 1,400 participants in the Framingham Heart Study, a decades-long project focused on risk factors for cardiovascular disease. The team discovered that bacteria called <em>Oscillibacter </em>take up and metabolize cholesterol from their surroundings, and that people carrying higher levels of the microbe in their gut had lower levels of cholesterol. They also identified the mechanism the bacteria likely use to break down cholesterol. The results suggest that interventions that manipulate the microbiome in specific ways could one day help decrease cholesterol in people. The findings also lay the groundwork for more targeted investigations of how changes to the microbiome affect health and disease.</p>

#Glyphosate, pathways to modern diseases II: #Celiac #sprue and #GlutenIntolerance

2013 December
Anthony Samsel and Stephanie Seneff

"Evidence of disruption of #GutBacteria by glyphosate is available for poultry (Shehata et al., 2013), cattle (Krüger et al., 2013), and swine (Carman et al., 2013). Glyphosate disrupts the balance of gut bacteria in poultry (Shehata et al., 2013), increasing the ratio of #pathogenic #bacteria to other commensal microbes. #Salmonella and #Clostridium are highly resistant to glyphosate, whereas Enterococcus, Bifidobacteria, and Lactobacillus are especially susceptible. Glyphosate was proposed as a possible factor in the increased risk to Clostridium botulinum infection in cattle in Germany over the past ten to fifteen years (Krüger et al., 2013b). Pigs fed GMO corn and soy developed widespread intestinal #inflammation that may have been due in part to glyphosate exposure (Carman et al., 2013).

"Glyphosate Effect: #Desulfovibrio overgrowth
Dysfunction: hydrogen sulfide gas
Result: inflammation"

Full article:
ncbi.nlm.nih.gov/pmc/articles/

PubMed Central (PMC)Glyphosate, pathways to modern diseases II: Celiac sprue and gluten intoleranceCeliac disease, and, more generally, gluten intolerance, is a growing problem worldwide, but especially in North America and Europe, where an estimated 5% of the population now suffers from it. Symptoms include nausea, diarrhea, skin rashes, macrocytic ...
Continued thread

Can #glyphosate’s disruption of the gut #microbiome and induction of sulfate deficiency explain the epidemic in #gout and associated diseases in the #industrialized world?

June 2017Journal of Biological Physics and Chemistry 17(2):53-76

Authors: Stephanie Seneff, et al.

"Gout is an acute or chronic #inflammatory disease characterized by intense pain, redness and swelling in joints, mainly the metatarsophalangeal joint. Gout is linked to an increased risk of diabetes and heart disease. The traditional medical view holds that high dietary purines, fructose and alcohol are key causal factors. However, this does not explain the entirety of the pathophysiology. In this paper, we review the literature on gout and propose a functional
role for the #inflammatory signaling cascade to restore vascular health. Our findings suggest that the primary factor behind the recent gout epidemic is dietary glyphosate, with #iron overload and #fungus overgrowth as secondary contributing factors. The increase in gout
prevalence in the #UnitedKingdom correlates well with both diabetes prevalence and the use of glyphosate in #agriculture. The activities that take place in the gouty joint are directed
towards renewing sulfate supplies to the immune cells and to the vasculature. Dangerously high serum viscosity impairs vascular sulfate synthesis, promoting crystal formation and immune cell infiltration into the joint, provoking a gout attack. The resulting complex signaling cascade leads to hydrogen sulfide (H2S) synthesis, release of ATP and reactive oxygen, and activation of enzymes that oxidize H2S to sulfate, eventually restoring sulfate supplies to themacrophages invading the synovial fluid. We urge that government regulators reassess the
#toxicity of glyphosate to humans."

researchgate.net/publication/3

Um, #glyphosate has been proven to increase the amount of #Desulfovibrio bacteria in the gut... (Articles in comments)

#ParkinsonsDisease could be prevented after scientists discovered its cause.

Researchers discovered that a certain strain of bacteria in the gut is the likely cause of Parkinson’s disease in the majority of cases.

Their study discovered that these bacteria, called Desulfovibrio, can be detected and removed which could prevent the disease.

Read more:
msn.com/en-us/health/medical/s

www.msn.comMSN