Latest news from the NephroLab Cologne – more specifically, from our Hippo- Team:
Our snRNA-Seq study on YAP and TAZ in kidney podocytes is now online open access in JASN!
Huge thanks to everyone on the team and the incredibly thorough reviewers at JASN!

Link: https://journals.lww.com/jasn/abstract/9900/transcriptional_regulators_yap_and_taz_have.598.aspx

#HippoSignaling #YAP #TAZ #Kidney #Kidneydisease #Science #snRNASeq #cellsignaling #FSGS #podocyte #Nephrology #Niere #Nephrolab #Nephrologie

@ukkoeln @UniKoeln @CECAD

A developer of treatments for Alzheimer's disease that seeks to improve the condition of the brain's support cells is raising £48 million ($US 61 million) in its first venture round.

https://sciencebusiness.technewslit.com/?p=45307

Too many gaps to fill before changing the narrative in textbooks.
Many possible incremental steps from anaerobic to aerobic life (as we know it and before). e.g. evolution of cell membranes and nuclear factors that influence bidirectional transition to oxygen utilization and forming multicellular organisms, which depends on cell signaling. #biophysics #CellSignaling #EvolutionaryBiology

https://science.ku.dk/english/press/news/2023/life-on-earth-didnt-arise-as-described-in-textbooks/

The dose & duration of type I #interferon exposure is interpreted by a signaling module with a stimulus-contingent positive feedback loop. A secondary potentiated phase of ISGF3 activates pro-inflammatory gene expression https://www.embopress.org/doi/full/10.15252/msb.202211294 #cellsignaling #SystemsBiology
from Alex Hoffmann, UCLA

A new proteomic workflow establishing interdependencies between protein #phosphorylation & complex formation is applied to the signal integrator & Hippo pathway effector YAP1 http://bit.ly/3mJ4W0t
Matthias Gstaiger @eth_en
#proteomics #interactome #ProteinProteinInteractions #CellSignaling

Modeling & experimental analyses of a Golgi-localized GTPase circuitry that allows cancer cells to achieve self-sufficiency in growth factor signaling http://bit.ly/41DK7Dj
P Rangamani & P Ghosh, UCSD
#Gproteins #CellSignaling #EGFR #SystemsBiology

Interested in a #PhD in #proteomics and #cellsignaling? Check out this opportunity with me in @c4pr_liv with @andy___jones and @WatersCorp @NLD_BBSRCDTP https://www.findaphd.com/phds/project/enhanced-and-robust-characterisation-of-dynamic-protein-post-translational-protein-modifications/?p150420