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Dining & CookingMediterranean diet helps manage rheumatoid arthritis and Hashimoto’s, study shows <a href="https://www.diningandcooking.com/2034619/mediterranean-diet-helps-manage-rheumatoid-arthritis-and-hashimotos-study-shows/" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://www.diningandcooking.com/2034619/mediterranean-diet-helps-manage-rheumatoid-arthritis-and-hashimotos-study-shows/</a> <a href="https://vive.im/tags/AntiInflammatory" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#AntiInflammatory</a> <a href="https://vive.im/tags/Arthritis" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Arthritis</a> <a href="https://vive.im/tags/bacteria" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#bacteria</a> <a href="https://vive.im/tags/ClinicalTrial" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#ClinicalTrial</a> <a href="https://vive.im/tags/Cytokines" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Cytokines</a> <a href="https://vive.im/tags/Diabetes" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Diabetes</a> <a href="https://vive.im/tags/DiabetesMellitus" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#DiabetesMellitus</a> <a href="https://vive.im/tags/diet" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#diet</a> <a href="https://vive.im/tags/FattyAcids" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#FattyAcids</a> <a href="https://vive.im/tags/Genetic" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Genetic</a> <a href="https://vive.im/tags/ImmuneSystem" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#ImmuneSystem</a> <a href="https://vive.im/tags/Interferon" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Interferon</a> <a href="https://vive.im/tags/Mediterranean" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Mediterranean</a> <a href="https://vive.im/tags/MediterraneanDiet" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#MediterraneanDiet</a> <a href="https://vive.im/tags/nutrients" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#nutrients</a> <a href="https://vive.im/tags/OliveOil" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#OliveOil</a> <a href="https://vive.im/tags/RheumatoidArthritis" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#RheumatoidArthritis</a> <a href="https://vive.im/tags/Spondyloarthritis" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Spondyloarthritis</a> <a href="https://vive.im/tags/Thyroid" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Thyroid</a> <a href="https://vive.im/tags/Thyroiditis" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Thyroiditis</a> <a href="https://vive.im/tags/Type1Diabetes" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Type1Diabetes</a> <a href="https://vive.im/tags/Vegetables" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Vegetables</a>

Giuseppe MichieliPrevalence of <a href="https://mstdn.science/tags/EBV" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#EBV</a>, <a href="https://mstdn.science/tags/HHV6" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#HHV6</a>, <a href="https://mstdn.science/tags/HCMV" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#HCMV</a>, <a href="https://mstdn.science/tags/HAdV" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#HAdV</a>, <a href="https://mstdn.science/tags/SARS" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#SARS</a>-CoV-2, and <a href="https://mstdn.science/tags/Autoantibodies" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Autoantibodies</a> to Type I <a href="https://mstdn.science/tags/Interferon" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Interferon</a> in <a href="https://mstdn.science/tags/Sputum" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Sputum</a> from Myalgic Encephalomyelitis / <a href="https://mstdn.science/tags/CFS" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#CFS</a> Patients, <a href="https://etidiohnew.blogspot.com/2025/03/prevalence-of-ebv-hhv6-hcmv-hadv-sars.html" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://etidiohnew.blogspot.com/2025/03/prevalence-of-ebv-hhv6-hcmv-hadv-sars.html</a>

Thiago Carvalho'Human inborn errors of the type I IFN response pathway and auto-Abs neutralizing IFN-α, -β, and/or -ω can underlie severe viral illnesses. We report a simple assay for the detection of both types of condition.'<a href="https://qoto.org/tags/Immunology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Immunology</a> <a href="https://qoto.org/tags/Immunosky" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Immunosky</a> <a href="https://qoto.org/tags/interferon" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#interferon</a><a href="https://www.pnas.org/doi/10.1073/pnas.2402983121" rel="nofollow noopener noreferrer" target="_blank">https://www.pnas.org/doi/10.1073/pnas.2402983121</a>

RiffReporterIm <a href="https://mastodon.social/tags/Alter" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Alter</a> erhöht sich die Anfälligkeit für <a href="https://mastodon.social/tags/Infektionen" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Infektionen</a>. Das kann auch daran liegen, dass der <a href="https://mastodon.social/tags/K%C3%B6rper" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Körper</a> Autoantikörper gegen den wichtigen Immunbotenstoff <a href="https://mastodon.social/tags/Interferon" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Interferon</a> bildet. Was das bedeutet und wie wir uns schützen können: <a href="https://mastodon.social/tags/covid" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#covid</a> <a href="https://mastodon.social/tags/viren" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#viren</a> <a href="https://mastodon.social/@UlrikeGebhardt" class="u-url mention" rel="nofollow noopener noreferrer" target="_blank">@UlrikeGebhardt</a> <a href="https://www.riffreporter.de/de/wissen/erhoehte-infektanfaelligkeit-alter-immunabwehr-autoantikoerper-interferon-viren" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://www.riffreporter.de/de/wissen/erhoehte-infektanfaelligkeit-alter-immunabwehr-autoantikoerper-interferon-viren</a>

AuscandocHuman <a href="https://med-mastodon.com/tags/SARSCoV2" class="mention hashtag" rel="tag">#SARSCoV2</a> challenge uncovers local and systemic response dynamics | Nature <a href="https://www.nature.com/articles/s41586-024-07575-x" target="_blank" rel="nofollow noopener noreferrer" translate="no">https://www.nature.com/articles/s41586-024-07575-x</a> “observed that the <a href="https://med-mastodon.com/tags/interferon" class="mention hashtag" rel="tag">#interferon</a> response in blood preceded the nasopharyngeal response. Moreover, <a href="https://med-mastodon.com/tags/nasopharyngeal" class="mention hashtag" rel="tag">#nasopharyngeal</a> immune infiltration occurred early in samples from individuals with only transient infection and later in samples from individuals with sustained infection. High expression of <a href="https://med-mastodon.com/tags/HLADQA2" class="mention hashtag" rel="tag">#HLADQA2</a> before inoculation was associated with preventing sustained infection” <a href="https://med-mastodon.com/tags/COVID" class="mention hashtag" rel="tag">#COVID</a>

Thiago Carvalho'Here we examine the contribution of Mitogen Activated Protein Kinase (MAPK) signaling on IFNλ-mediated antiviral activity. We find that extracellular-signal-regulated kinase 5 (ERK5), a poorly characterized member of the conventional MAPK family, potentiates the antiviral efficacy of IFNλ.' <a href="https://qoto.org/tags/Preprint" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Preprint</a> <a href="https://qoto.org/tags/Immunology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Immunology</a> <a href="https://qoto.org/tags/InnateImmunity" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#InnateImmunity</a> <a href="https://qoto.org/tags/Interferon" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Interferon</a><a href="https://www.biorxiv.org/content/10.1101/2024.05.21.595218v1" rel="nofollow noopener noreferrer" target="_blank">https://www.biorxiv.org/content/10.1101/2024.05.21.595218v1</a>

Thiago Carvalho"Repurposing generic medicine has the potential to bring new treatments for infectious diseases to patients efficiently and equitably. In this study, we found that intranasal delivery of neomycin, a generic aminoglycoside antibiotic, induces the expression of interferon-stimulated genes (ISGs) in the nasal mucosa that is independent of the commensal microbiota." Mao, Akiko Iwasaki et al <a href="https://qoto.org/tags/Immunology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Immunology</a> <a href="https://qoto.org/tags/Interferon" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Interferon</a> <a href="https://www.pnas.org/doi/10.1073/pnas.2319566121" rel="nofollow noopener noreferrer" target="_blank">https://www.pnas.org/doi/10.1073/pnas.2319566121</a>

Martin Michaelis (he/him)Interesting study that shows an increased <a href="https://mastodonapp.uk/tags/interferon" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#interferon</a> response in nasal epithelial cells compared to adults. <a href="https://mastodonapp.uk/tags/COVID19" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#COVID19</a> <a href="https://www.nature.com/articles/s41564-024-01658-1" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://www.nature.com/articles/s41564-024-01658-1</a>

Scientific FrontlineA University of Cambridge-led study identifies the <a href="https://mastodon.social/tags/protein" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#protein</a> <a href="https://mastodon.social/tags/interferon" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#interferon</a> gamma (IFN-γ) as a potential <a href="https://mastodon.social/tags/biomarker" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#biomarker</a> for Long <a href="https://mastodon.social/tags/COVID" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#COVID</a> fatigue and highlights an <a href="https://mastodon.social/tags/immunological" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#immunological</a> mechanism underlying the disease <a href="https://mastodon.social/tags/Virology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Virology</a> <a href="https://mastodon.social/tags/Medical" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Medical</a> <a href="https://mastodon.social/tags/sflorg" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#sflorg</a> <a href="https://www.sflorg.com/2024/02/vi02212401.html" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://www.sflorg.com/2024/02/vi02212401.html</a>

Zoomers of the Sunshine CoastHow much we still don’t understand about our immune system… COVID-19 researchers discover hidden natural immune defence pathway They detected 10 new compounds made by the body in response to the SARS Cov-2 virus.VIPERIN—short for virus inhibitory protein, endoplasmic reticulum-associated, interferon-inducible—is a multifunctional, interferon-inducible protein that regulates virus replication. <a href="https://mstdn.ca/tags/interferon" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#interferon</a> <a href="https://mstdn.ca/tags/VIPERIN" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#VIPERIN</a> <a href="https://pubs.acs.org/doi/10.1021/acs.jproteome.3c00654" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://pubs.acs.org/doi/10.1021/acs.jproteome.3c00654</a><a href="https://medicalxpress.com/news/2024-02-covid-hidden-natural-immune-defense.html" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://medicalxpress.com/news/2024-02-covid-hidden-natural-immune-defense.html</a>

Zoomers of the Sunshine CoastBody's Interferon kills viruses:ROGER SEHEULT, MD @ROGERSEHEULT • FEB 9, 2024Things that increase it1) Sunlight <a href="https://sciencedirect.com/science/article/pii/S2468227619306635" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://sciencedirect.com/science/article/pii/S2468227619306635</a>2) Plant-based diet: <a href="https://nature.com/articles/s41591-023-02761-2" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://nature.com/articles/s41591-023-02761-2</a>3) Hydrotherapy <a href="https://pubmed.ncbi.nlm.nih.gov/3132509/" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://pubmed.ncbi.nlm.nih.gov/3132509/</a>4) Garlic <a href="https://pubmed.ncbi.nlm.nih.gov/17523869/" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://pubmed.ncbi.nlm.nih.gov/17523869/</a>Things that decrease it1) Tylenol <a href="https://pubmed.ncbi.nlm.nih.gov/20544007/" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://pubmed.ncbi.nlm.nih.gov/20544007/</a>2) Ivermectin <a href="https://ncbi.nlm.nih.gov/pmc/articles/PMC9823263/" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://ncbi.nlm.nih.gov/pmc/articles/PMC9823263/</a><a href="https://mstdn.ca/tags/Interferon" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Interferon</a> <a href="https://mstdn.ca/tags/viruses" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#viruses</a>

Giuseppe Michieli<a href="https://mstdn.science/tags/Omicron" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Omicron</a> <a href="https://mstdn.science/tags/Spike" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Spike</a> confers enhanced <a href="https://mstdn.science/tags/infectivity" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#infectivity</a> and <a href="https://mstdn.science/tags/interferon" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#interferon</a> <a href="https://mstdn.science/tags/resistance" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#resistance</a> to <a href="https://mstdn.science/tags/SARS" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#SARS</a>-CoV-2 in <a href="https://mstdn.science/tags/human" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#human</a> nasal tissue <a href="https://www.nature.com/articles/s41467-024-45075-8" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://www.nature.com/articles/s41467-024-45075-8</a>

Giuseppe MichieliLongitudinal single <a href="https://mstdn.science/tags/cell" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#cell</a> <a href="https://mstdn.science/tags/atlas" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#atlas</a> identifies complex temporal <a href="https://mstdn.science/tags/relationship" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#relationship</a> between type I <a href="https://mstdn.science/tags/interferon" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#interferon</a> response and <a href="https://mstdn.science/tags/COVID19" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#COVID19</a> severity <a href="https://www.nature.com/articles/s41467-023-44524-0" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://www.nature.com/articles/s41467-023-44524-0</a>

Rhyothemisfrom ⬆️ "These nettles are renowned for inflicting extremely painful stings that are characterized by acute electric shocklike, piercing, pricking and burning sensations lasting for many hours, followed by intermittent painful flares and allodynia that persists for days or even weeks."Similarities to other types of neuropathic pain, including small fiber neuropathy and Long Covid associated neuropathy.~"These results provide important insights into the function of NaV channels in sensory neurons, identify TMEM233 as a previously unknown NaV1.7interacting protein, and describe the dispanins as bifunctional proteins that cause allosteric changes in channel gating upon binding of pain causing venom peptides."~Not finding much on TMEM233. Some dispanins are interferon activated.review article from 2012: - The Dispanins: A Novel Gene Family of Ancient Origin That Contains 14 Human Members <a href="https://doi.org/10.1371%2Fjournal.pone.0031961" rel="nofollow noopener noreferrer" target="_blank">https://doi.org/10.1371%2Fjournal.pone.0031961</a>"The IFITM1–3 proteins were identified 25 years ago as being upregulated by interferons (IFN) [6]. Recently they received considerable attentions as IFITM1–3 were found to prevent infection of a growing list of viruses such as HIV-1, SARS influenza A H1N1, West Nile and Dengue fever viruses [7], [8], [9], [10]. Hence, proteins of the IFITM family mediate part of the antiviral response orchestrated by IFNs. However, the IFITM family is also involved in other processes such as oncogenesis, bone mineralization (IFITM5) and germ cell development (IFITM1 and 3) and IFITM5 has not been identified as interferon-inducible [11], [12], [13], [14]. Although the biological roles of the IFITM genes are emerging, no thorough evolutionary analysis has been performed on this group.In this study, we sought to infer the evolutionary history of the human IFITM genes and identify potential homologues. We mined 36 eukaryotic species, covering all major eukaryotic groups, and found that the IFITMs form a subfamily in a larger novel family that has ten human members in addition to the four IFITM genes. We propose Dispanins as a novel name for this family, which refers to their common 2TM structure. "<a href="https://zeroes.ca/tags/TMEM233" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#TMEM233</a> <a href="https://zeroes.ca/tags/dispanins" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#dispanins</a> <a href="https://zeroes.ca/tags/IFITM" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#IFITM</a> <a href="https://zeroes.ca/tags/interferon" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#interferon</a> <a href="https://zeroes.ca/tags/Pain" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Pain</a> <a href="https://zeroes.ca/tags/neuropathy" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#neuropathy</a>

halama_immuno<a href="https://mstdn.science/tags/innateimmunity" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#innateimmunity</a> in action: <a href="https://mstdn.science/tags/immunotherapy" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#immunotherapy</a> against <a href="https://mstdn.science/tags/breastcancer" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#breastcancer</a> with TLR3 ligand and interferon alpha. Only six patients in this <a href="https://mstdn.science/tags/trial" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#trial</a> , but biopsy analyses show improved <a href="https://mstdn.science/tags/inmuneinfiltration" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#inmuneinfiltration</a> with <a href="https://mstdn.science/tags/TILs" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#TILs</a> and is linked to clinical observations. <a href="https://mstdn.science/tags/interferon" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#interferon</a> <a href="https://mstdn.science/tags/cytokines" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#cytokines</a> <a href="https://mstdn.science/tags/immunology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#immunology</a> <a href="https://mstdn.science/tags/macrophages" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#macrophages</a> <a href="https://mstdn.social/@chfloudas" class="u-url mention" rel="nofollow noopener noreferrer" target="_blank">@chfloudas</a> <a href="https://jitc.bmj.com/content/11/11/e007381" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://jitc.bmj.com/content/11/11/e007381</a>

Gabriele PollaraAlways been curious how different interferons that signal through same receptor can have different functional effect. Here's a paper that shows how: <a href="https://med-mastodon.com/tags/interferon" class="mention hashtag" rel="tag">#interferon</a> <a href="https://med-mastodon.com/tags/immunology" class="mention hashtag" rel="tag">#immunology</a> <a href="https://med-mastodon.com/tags/receptor" class="mention hashtag" rel="tag">#receptor</a> <a href="https://med-mastodon.com/tags/receptors" class="mention hashtag" rel="tag">#receptors</a> <a href="https://med-mastodon.com/tags/Signalling" class="mention hashtag" rel="tag">#Signalling</a> <a href="https://www.science.org/doi/10.1126/scisignal.adf5494" target="_blank" rel="nofollow noopener noreferrer" translate="no">https://www.science.org/doi/10.1126/scisignal.adf5494</a>

Scientific FrontlineResearchers found that <a href="https://mastodon.social/tags/interferon" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#interferon</a>-gamma signaling caused hyperactivation of ERK in human <a href="https://mastodon.social/tags/melanoma" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#melanoma</a> cell lines. The <a href="https://mastodon.social/tags/ERK" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#ERK</a> protein, when hyperactive, causes stress in the <a href="https://mastodon.social/tags/cell" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#cell</a>, and this stress ultimately leads to cell death through specific proteins called <a href="https://mastodon.social/tags/DR5" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#DR5</a> and <a href="https://mastodon.social/tags/NOXA" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#NOXA</a> <a href="https://mastodon.social/tags/Cancer" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Cancer</a> <a href="https://mastodon.social/tags/Medical" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Medical</a> <a href="https://mastodon.social/tags/sflorg" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#sflorg</a> <a href="https://www.sflorg.com/2023/10/med10102301.html" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://www.sflorg.com/2023/10/med10102301.html</a>

Thiago CarvalhoNow I cant stop singing "more than a spike gene" to the tune of the BeeGees (protein didnt fit the meter).'We assessed the role of ORF6 during infection using recombinant viruses carrying a deletion or loss-of-function (LoF) mutation in ORF6. ORF6 plays key roles in interferon antagonism and viral pathogenesis by interfering with nuclear import and specifically the translocation of IRF and STAT transcription factors.' <a href="https://qoto.org/tags/Covid" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Covid</a> <a href="https://qoto.org/tags/Covid19" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Covid19</a> <a href="https://qoto.org/tags/SarsCov2" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#SarsCov2</a> <a href="https://qoto.org/tags/Interferon" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Interferon</a> <a href="https://qoto.org/tags/Virology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Virology</a> <a href="https://qoto.org/tags/Immunology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Immunology</a> <a href="https://qoto.org/tags/InnateImmunity" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#InnateImmunity</a><a href="https://www.sciencedirect.com/science/article/pii/S1931312823003281" rel="nofollow noopener noreferrer" target="_blank">https://www.sciencedirect.com/science/article/pii/S1931312823003281</a>

Victoria Stuart 🇨🇦 🏳️‍⚧️Aging Brain: Is Misplaced DNA to Blame? <a href="https://www.science.org/content/blog-post/aging-brain-misplaced-dna-blame" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://www.science.org/content/blog-post/aging-brain-misplaced-dna-blame</a> Discussion: <a href="https://news.ycombinator.com/item?id=37169226" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://news.ycombinator.com/item?id=37169226</a>Comment: aging is ubiquitous, stochastic, multifactorial, physiochemical, innate (cell/molecular biology), with environmental factors. Intimately related to disease, including cancer. That said, any insight contributes to understanding. 👍️<a href="https://mastodon.social/tags/ageing" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#ageing</a> <a href="https://mastodon.social/tags/aging" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#aging</a> <a href="https://mastodon.social/tags/DNA" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#DNA</a> <a href="https://mastodon.social/tags/CystolicDNA" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#CystolicDNA</a> <a href="https://mastodon.social/tags/neurodegeneration" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#neurodegeneration</a> <a href="https://mastodon.social/tags/CellularSignaling" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#CellularSignaling</a> <a href="https://mastodon.social/tags/cGAS_STING" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#cGAS_STING</a> <a href="https://mastodon.social/tags/interferon" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#interferon</a> <a href="https://mastodon.social/tags/autoimmunity" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#autoimmunity</a> <a href="https://mastodon.social/tags/lupus" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#lupus</a> <a href="https://mastodon.social/tags/dsDNA" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#dsDNA</a>

TheBinderLabFinally, it’s out! I must say, I am really, really fond of this paper– if you are into <a href="https://mstdn.science/tags/innateimmunity" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#innateimmunity</a>, the <a href="https://mstdn.science/tags/antiviralresponse" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#antiviralresponse</a> and <a href="https://mstdn.science/tags/interferon" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#interferon</a>, I think you may enjoy reading it: <a href="https://www.life-science-alliance.org/content/6/10/e202302059" rel="nofollow noopener noreferrer" target="_blank">https://www.life-science-alliance.org/content/6/10/e202302059</a>Nothing spectacularly new, but very comprehensive characterization of the <a href="https://mstdn.science/tags/RIGI" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#RIGI</a> and <a href="https://mstdn.science/tags/IFN" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#IFN</a> pathway!

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