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Auscandoc

A model of infection reveals ACE2-dependent susceptibility and differentiation impairment in | Nature Cell Biology nature.com/articles/s41556-023 “We identified that syncytiotrophoblasts could be infected through angiotensin-converting enzyme 2 (). Using a co-culture model of vertical transmission, we confirmed the ability of the virus to infect syncytiotrophoblasts through a previous endometrial cell infection.”

NatureA placental model of SARS-CoV-2 infection reveals ACE2-dependent susceptibility and differentiation impairment in syncytiotrophoblasts - Nature Cell BiologyChen, Neil, Tan, Rudraraju et al. use an induced trophoblast stem-cell-based model of SARS-CoV-2 infection and identify syncytiotrophoblasts as the cells targeted by the virus in the early placenta.
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“We further demonstrated changes in infected syncytiotrophoblasts that led to impairment of processes, reduced secretion of hormone and morphological changes vital for syncytiotrophoblast function. Furthermore, different strategies and drugs restore these impairments.”

Jul 17, 2023, 10:59 PM·Public·Toot!
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