Prep mostly done. So it's stage 1 of checking out how to deal with ongoing (37 years) Crohn's and diverticulitis disease tomorrow. First up is a colonoscopy, which always fascinates the scientist in me if nothing else. #Crohns #Colitis #medicine

While I’m the last person to ride any diet hype train nonsense, I decided to try Soylent as it’s $3.50 a bottle for a meal. About half the cost of a smoothie I make myself.

I’ve found following a colitis flare like I just experienced eliminating at least one meal of solid food a day REALLY helps my stomach recover.

I am surprised and impressed. The meal replacement drinks are universally pretty ok to good tasting. I am full for 4 to 6 hours afterward with no urge to snack. And my stomach is rebounding quickly. I might stick with this for a couple more months just because I am enjoying the convenience too.

kiddo's crabs have slightly woken. is this gonna be a thing now? an additional medical issue? the er visit was like 2 weeks ago. ugh. my poor kiddo. #colitis

Recently I was in the queue for the doctor. A woman in front was so distressed that she was getting no help that she openly, in public, begged for help, and spoke of the fact that she had been bleeding from the gut for 4 years since covid.
She likely has crohns disease or colitis.
It's unbelievable to me that people are being ignored.
Those of us already diagnosed are aware that covid has much worsened our disease.
The doctors are so bad it's surreal.
#longcovid #crohns #colitis

#Cannabinoids as novel #AntiInflammatory drugs

by Prakash Nagarkatti, et al.
October, 2009

Abstract:

"Cannabinoids are a group of compounds that mediate their effects through cannabinoid receptors. The discovery of Δ9-tetrahydrocannabinol (#THC) as the major psychoactive principle in marijuana, as well as the identification of #cannabinoid receptors and their endogenous ligands, has led to a significant growth in research aimed at understanding the physiological functions of cannabinoids. Cannabinoid receptors include CB1, which is predominantly expressed in the brain, and CB2, which is primarily found on the cells of the immune system. The fact that both CB1 and CB2 receptors have been found on #immune cells suggests that cannabinoids play an important role in the regulation of the immune system. Recent studies demonstrated that administration of THC into mice triggered marked apoptosis in T cells and dendritic cells, resulting in immunosuppression. In addition, several studies showed that cannabinoids downregulate #cytokine and chemokine production and, in some models, upregulate T-regulatory cells (Tregs) as a mechanism to suppress #inflammatory responses. The #endocannabinoid system is also involved in #immunoregulation. For example, administration of endocannabinoids or use of inhibitors of enzymes that break down the endocannabinoids, led to immunosuppression and recovery from immune-mediated injury to organs such as the liver. Manipulation of endocannabinoids and/or use of exogenous cannabinoids in vivo can constitute a potent treatment modality against inflammatory disorders. This review will focus on the potential use of cannabinoids as a new class of anti-inflammatory agents against a number of inflammatory and autoimmune diseases that are primarily triggered by activated T cells or other cellular immune components."

Executive summary

- Cannabinoids, the active components of #CannabisSativa, and endogenous cannabinoids mediate their effects through activation of specific cannabinoid receptors known as cannabinoid receptor 1 and 2 (CB1 and CB2).

- The cannabinoid system has been shown both in vivo and in vitro to be involved in regulating the immune system through its immunomodulatory properties.

- Cannabinoids suppress inflammatory response and subsequently attenuate disease symptoms. This property of cannabinoids is mediated through multiple pathways such as induction of apoptosis in activated immune cells, suppression of cytokines and chemokines at inflammatory sites and upregulation of FoxP3+ regulatory T cells.

- Cannabinoids have been tested in several experimental models of autoimmune disorders such as #MultipleSclerosis, #RheumatoidArthritis, #colitis and #hepatitis and have been shown to protect the host from the pathogenesis through induction of multiple anti-inflammatory pathways.

- Cannabinoids may also be beneficial in certain types of #cancers that are triggered by #ChronicInflammation In such instances, cannabinoids can either directly inhibit tumor growth or suppress inflammation and tumor angiogenesis.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2828614/

It’s a hidden cause of #diarrhea and the development of the disease is poorly understood. Multiple factors work against the diagnosis of #microscopic #colitis, an inflammatory #digestive disease
#Medical #sflorg
https://www.sflorg.com/2023/12/med12132305.html

Treatment of the chronic inflammatory bowel disease #ulcerative #colitis often produces unsatisfactory results. Researchers at the University of Bern have now developed a lipid gel that is administered directly to the inflamed part of the #intestine
#Chemistry #Medical #Pharmaceutical #sflorg
https://www.sflorg.com/2023/10/chm10242301.html

Proud of the impressive #thesis by the talented Vera Asscher: #Inflammatory #Bowel #Disease; from gut feeling towards evidence-based #medicine

Looking farward to the defence on June 6th

Maruyama et al, 2023: Of #COVID19 patients (PCR/RAT confirmed) presenting to the ER with "mild" symptoms, 183 had #gastrointestinal symptoms, of which 20 had GI bleeding, 17 of them having acute hemorrhagic #colitis of the left hemicolon.
https://www.reddit.com/r/COVIDZero/comments/11v20it/maruyama_et_al_2023_of_covid19_patients_pcrrat/

This is Lacie. June had to go to the hospital early Wednesday. She was crying a lot, and when she got home she told me she had colitis. I don’t understand that word. But she really wanted a bubble bath. I don’t understand those either, but I sat and played lifeguard for her because I am a good girl. #colitis #cat #TuxedoCat #TuxedoCatsOfMastodon #lifeguard #NEISVoid

Family of hNQO1 Activatable Near-Infrared Fluoro-Photoacoustic Probes for Diagnosis of Wound Infection and Ulcerative Colitis
Anal. Chem. 2023, 95, 2, 898–906
https://doi.org/10.1021/acs.analchem.2c03436
#nearir #colitis #infection

[Automatic repost https://twitter.com/dystobot/status/1611015958683951106]

RT @LunaRivera96: WHY IS IT SO HARD TO LIVE WITH CHRONIC ILLNESS?
#SLE #lupus #chronicillness #fibromyalgia #MultipleSclerosis #cancer #lymedisease #CRPS #Chiari #diabetes #epilepsy #sjogrens #crohns #colitis #dystonia #migraines https://t.co/cH9hhfUPvT

Chronic exposure to synthetic food #colorant Allura Red AC promotes susceptibility to experimental #colitis via intestinal serotonin in mice | Nature Communications

https://www.nature.com/articles/s41467-022-35309-y

Update:
Not #Fibromyalgia. Acute #colitis. Caught before sepsis, thankfully. I feel like absolute shit, but... I'm still here.
Beloveds, take care of yourselves and keep your fingers crossed I didn't also get covid from my emergency hospital visit.

"I can’t change any of it and coming to terms with this has been the healthiest thing for me so far."

It's #Crohns and #Colitis Awareness Week! Hence our foreign affairs reporter Heather Carrick has shared her Crohn's journey on NationalWorld.

https://www.nationalworld.com/news/opinion/crohns-colitis-awareness-week-2022-learned-living-invivisble-illness-3940016 #health #healthcare #awareness

#AIBD2022 Terapias autorizadas en el tratamiento del #colitis Ulcerosa.
Encuentra en @Gastro_Times@twitter.com los mensajes a llevar a casa.
Ingresa a http://www.gastrotimes.online