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#behaviour

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Why We Do What We Do by Helena Boschi, 2020

Understanding Our Brain to Get the Best Out of Ourselves and Others

Why We Do What We Do combines scientific research with concrete examples and illustrative stories to clarify the complex mechanisms of the human brain. It offers valuable insights into how our brain works every day, at home and at work, and provides practical ideas and tips to help us lead happy, healthy and productive lives.

@bookstodon
#books
#brain
#behaviour

Continued thread

Day 32 cont 🗳️⚔️🤜🤛👊

As the election gets closer, #extremism and #conflict is happening at polling booths with unruly candidate, party members and constituants.

“A barrage of #complaints about #threatening and #aggressive #behaviour at polling booths has fuelled tension in Australia’s most hotly #contested #electorates and prompted the #ElectoralCommission to warn #candidates in marginal seats that such behaviour would discourage #voters

#AusPol <archive.md/5KgGv> / <smh.com.au/politics/federal/th> (paywall)

Behavioral Neurobiology of PTSD by Eric Vermetten et al, 2018

This volume focuses on the behavioral neuroscience that supports our understanding of the neurobiology of trauma risk and response. The collection of articles focuses on both preclinical and clinical reviews of (1) state-of-the-art knowledge of mechanisms of posttraumatic stress disorder (PTSD) and co-occurring disorders.

link.springer.com/book/10.1007

@bookstodon
#books
#nonfiction
#NeuroBiology
#brain
#behaviour
#PTSD

Why We Do What We Do: Understanding Our Brain to Get the Best Out of Ourselves and Others by Helena Boschi, 2020

Why We Do What We Do combines scientific research with concrete examples and illustrative stories to clarify the complex mechanisms of the human brain. It offers valuable insights into how our brain works every day, at home and at work, and provides practical ideas and tips to help us lead happy, healthy and productive lives.

@bookstodon
#books
#nonfiction
#brain
#behaviour

I’m becoming more and more self-aware how I (over?) explain my self in most of my life contexts.

What I my self think is I don’t want to leave people confused of that I am thinking. So I explain.

How it is also perceived (as I’ve learned) is I am mansplaining.

I’m puzzled and seem not to be able to reach any conclusion whether my behaviour is for the good or for the worse.

📰 "A heart releasing neuropeptide that synchronizes brain-heart regulation during courtship behavior"
biorxiv.org/content/10.1101/20
#InternalState
#Drosophila #Behaviour

bioRxiv · A heart releasing neuropeptide that synchronizes brain-heart regulation during courtship behaviorDistinct internal states drive varied animal behaviors, yet the mechanisms by which non-neuronal factors encode these states remain largely unknown. Here, we show that cardiac activity regulates internal mating states through a conserved brain-heart axis in male flies and mice. In Drosophila, a ppk23-P1 pathway triggers heart rate acceleration upon female perception via crustacean cardioactive peptide, while the heart secretes ion transport peptide that feeds back onto P1 neurons to enhance courtship. Ejaculation rapidly decreases heart rate via Corazonin, mitigating prolonged tachycardia. In mice, a conserved Substance P-TacR1 pathway modulates courtship. Finally, we developed a computational framework to decode internal mating states from cardiac physiology, revealing distinct cardiac signatures. Our findings unveil a novel role for heart-derived neuropeptides in internal state regulation, elucidate a positive feedback loop between the heart and brain, and demonstrate the evolutionary conservation of the brain-heart axis in orchestrating dynamic behavioral and physiological states. ### Competing Interest Statement The authors have declared no competing interest.
bioRxiv · Intestinal control of feeding initiation in Drosophila melanogasterThe interplay between feeding and excretion is essential for organismal nutrition and survival, yet their mechanistic coupling remains poorly understood. At the onset of life, feeding must be initiated while developmental waste products — the meconium — need to be eliminated. Using Drosophila as a model system, we explored the in vivo mechanisms coordinating these processes. We developed novel behavioral assays for newly eclosed flies and discovered that, similar to neonatal mammals, Drosophila excrete their meconium shortly after eclosion. Remarkably, feeding initiation occurs only after partial meconium elimination. We identified a cis-regulatory element associated with the apterous gene, which, when disrupted, prevents both meconium excretion and adult feeding initiation. These flies develop hindgut obstruction, avoid food, and exhibit increased proboscis extension sleep — a behaviour we found plays a functional role in waste clearance under normal conditions. Through experimental inhibition of meconium excretion, we established that this process is prerequisite for feeding initiation, suggesting a gut – to – brain signaling circuit that couples these fundamental physiological processes. The progression of phenotypes we observed parallels the hallmarks of mechanical obstruction in humans. Our findings reveal previously unrecognized links between intestinal clearance, feeding behavior, and survival, with potential implications for understanding similar processes across species. ### Competing Interest Statement The authors have declared no competing interest.

📰 "Characterization Eclosion Hormone Receptor function reveals differential hormonal control of ecdysis during Drosophila development."
biorxiv.org/content/10.1101/20
#Drosophila #Behaviour

bioRxiv · Characterization Eclosion Hormone Receptor function reveals differential hormonal control of ecdysis during Drosophila development.Neuromodulators and peptide hormones play important roles in regulating animal behavior. A well-studied example is ecdysis, which is used by insects to shed their exoskeleton at the end of each molt. Ecdysis is initiated by Ecdysis Triggering Hormone (ETH) and Eclosion Hormone (EH), which interact via positive feedback to coordinate the sequence of behavioral and physiological changes that cause exoskeleton shedding. Whereas the cell types targeted by ETH are well characterized, those targeted by EH have remained largely unknown due to limited characterization of the EH receptor (EHR). A gene encoding an EHR has been described in the oriental fruit fly, B. dorsalis, and in the desert locust, Schistocerca gregaria. However, little is known in these species about its expression pattern and its precise role at ecdysis, and no other insect EHRs are known. Here we analyze CG10738, the Drosophila ortholog of the B. dorsalis gene encoding EHR, and show that expressing it in cells confers sensitivity to EH. In addition, mutations of CG10738 specifically disrupt ecdysis, phenocopying the knockout of the EH gene. Together, these results indicate that CG10738 encodes the Drosophila EHR. As in B. dorsalis, EHR is expressed in the ETH-producing Inka cells; in addition, it is expressed in many known targets of ETH, including the neurons responsible for the secretion of other ecdysis-related peptides, such as CCAP and EH itself. Our results from targeted knockdown and rescue experiments reveal that EHR is required for ecdysis in diverse cell types and that the role of EHR in different targets differs with developmental stage. Our findings indicate extensive convergence of EH and ETH signaling and provide an exemplar of the complex mechanisms by which hormones control animal behavior. ### Competing Interest Statement The authors have declared no competing interest.