#Pancreatic ductal #adenocarcinoma (PDAC) is a deadly #cancer. @RoLiefke &co show that chromatin regulator SAMD1 represses EMT-related genes, inhibiting cellular migration, and is downregulated during #PDAC progression by #E3ligase FBXO11 #PLOSBiology https://plos.io/4crkx94
Targeted protein degradation #PROTAC is a promising avenue for drug development. This study shows that alkenyl oxindole compounds act as novel #E3ligase ligands & recruit the CRL4-DCAF11 E3 #ubiquitin ligase complex for substrate degradation #PLOSBiology https://plos.io/3WV1U9q
Stabilizing FOXF1 to treat #AlveolarCapillaryDysplasia
Chemical screening->TanFe
Ubiquitination of FOXF1 viabinding to #E3Ligase HECTD1/SHPRH/NEURL1B etc->
Restoring Lung #Angiogenesis of Foxf1+/-
Dr. Vladimir Kalinichenko lab Am J Respir Crit Care Med 2022
https://www.atsjournals.org/doi/10.1164/rccm.202207-1332OC
How FOXF1 impacts #EndothelialCell #Angiogenesis?
As a transcription factor for S1PR1 & VE-Cad
An excellent story from Dr. Vladimir Kalinichenko lab @scisignal 2016
FOXF1 maintains endothelial barrier function and prevents edema after lung injury
https://www.science.org/doi/10.1126/scisignal.aad1899
Alveolar Capillary Dysplasia with Misalignment of Pulmonary Veins, due to FOXF1 heterozygous mutation, has very complex Lung & ex-Lung vascular phenotypes
A few reads
https://diagnosticpathology.biomedcentral.com/articles/10.1186/s13000-020-00972-6
https://www.nature.com/articles/jp201494
https://www.nature.com/articles/ejhg2012171
https://www.jpeds.com/article/S0022-3476(04)00647-X/fulltext
K63 #Ubiquitination of #YAP by SKP2 #E3Ligase
its nuclear import
Synergized with mTORC1-PERK-ATF4 axis in renal #Cystogenesis#JuvenileCysticKidney #Ciliopathy
A #CellCycle-specific regulation of YAP?
Dr. Andrew Karaplis lab JCI 2022
https://www.jci.org/articles/view/153943
