A HS student emailed me out of the blue to do an interview as part of her capstone project on #Alzheimer's. I spoke w/her about #brain science & #caregiving. She's 18, her family has the #APOE4 gene - a risk factor for the disease - & she will study neuroscience to find a cure for Alzheimer's. She's smart, determined, & I had chills listening to her story and her passion. The senseless, fascistic #NIH cuts are imperiling the potential, the future of people like her, & our own.
Recent searches
Search options
Administered by:
#APOE4
0 posts0 participants0 posts today
A HS student emailed me out of the blue to do an interview as part of her capstone project on #Alzheimer's. I spoke w/her about #brain science & #caregiving. She's 18, her family has the #APOE4 gene - a risk factor for the disease - & she will study neuroscience to find a cure for Alzheimer's. She's smart, determined, & I had chills listening to her story and her passion. The senseless, fascistic #NIH cuts are imperiling the potential, the future of people like her, & our own.
APOE4 gene may influence brain barrier function in early stages of Alzheimer’s disease https://www.psypost.org/apoe4-gene-may-influence-brain-barrier-function-in-early-stages-of-alzheimers-disease/?utm_source=dlvr.it&utm_medium=mastodon #AlzheimersDisease #APOE4 #brainbarrier #neurodegeneration #Alzheimersrisk
Continued thread
/1
On the same (general) topic: individual genetic susceptibility ...
Genes known to increase the risk of Alzheimer's may actually be an inherited form of the disorder, researchers say
https://www.ctvnews.ca/health/genes-known-to-increase-the-risk-of-alzheimer-s-may-actually-be-an-inherited-form-of-the-disorder-researchers-say-1.6943195
https://www.nytimes.com/2024/05/06/health/alzheimers-cause-gene-apoe4.html
APOE4 homozygosity represents a distinct genetic form of Alzheimer’s disease
https://www.nature.com/articles/s41591-024-02931-w
CTVNews · Genes known to increase the risk of Alzheimer's may actually be an inherited form of the disorder, researchers sayAlzheimer’s disease may be inherited more often than previously known, according to a new study that paints a clearer picture of a gene long known to be linked to the common form of dementia.
Study Suggests #Genetics as a Cause, Not Just a Risk, for Some #Alzheimer’s
People with two copies of the #gene variant #APOE4 are almost certain to get Alzheimer’s, say researchers, who proposed a framework under which such #patients could be diagnosed years before symptoms.
https://www.nytimes.com/2024/05/06/health/alzheimers-cause-gene-apoe4.html
https://archive.ph/yTtsM
A long-awaited AlzForum's take on the news that ApoE4 homozygotism means in fact an AD pathology (though not necessarily dementia before death), https://www.alzforum.org/news/research-news/do-two-apoe4-alleles-always-mean-alzheimers
The comments-section gives a glimpse of some of the trenchlines regarding the treatment of dementia, but I guess the prevention-camp has only just been strirred up from their Sleeping Beauty's slumber.
I, as an example, still have only a 1 % measured risk of acquiring AD, according to some widely used screens, and no "preventable risk factors" except maybe age. Too bad, my genetic inheritance seems to have been enough to skew the Amyloid-Beta balance early on. Luckily, I was recruited to the aducanumab-study for four years (a precursor of lecanemab with more severe side-effects), and probably got some more years to be able to think things like these.
www.alzforum.orgDo Two APOE4 Alleles Always Mean Alzheimer's? | ALZFORUM
Mechanic Alzheimer’s disease seen in near 100% APOE4 homozygotes
“Findings revealed that almost all APOE4 homozygotes exhibited AD pathology and had significantly higher levels of AD biomarkers from age 55 compared to #APOE3 homozygotes.
By age 65, nearly all had abnormal amyloid levels in cerebrospinal fluid, and 75% had positive #amyloid scans, with the prevalence of these markers increasing with age, indicating near-full penetrance of AD biology in #APOE4 homozygotes”
#Alzheimers #Dementia
https://pbs.twimg.com/media/GM524u1bEAAJoAl.jpg
New Genetic Form of Alzheimer's Identified in People With Common Risk Factor : ScienceAlert
https://www.sciencealert.com/new-genetic-form-of-alzheimers-identified-in-people-with-common-risk-factor
#Alzheimers
#Genetics
#GeneticFormOfAlzheimers
#ApolipoproteinE4
#APOE4
#AutosomalDominantAlzheimersDisease
#ADAD
#APP
#DownSyndrome
ScienceAlert · New Genetic Form of Alzheimer's Identified in People With Common Risk FactorWe know that inheriting two copies of a specific gene variant, called apolipoprotein E4 (APOE4), greatly increases the risk of developing Alzheimer's disease later in life.
Die Genvariante #APOE4 ist nicht nur Risikofaktor für #Alzheimer sondern könnte laut einer Studie in Nature Medicine eine genetische Form der Erkrankung sein. Unabhängige Forschende finden die Ergebnisse überzeugend: https://www.sciencemediacenter.de/alle-angebote/research-in-context/details/news/apoe4-vom-risikogen-zur-genetischen-alzheimer-erkrankung/?mtm_campaign=mastodon&mtm_kwd=apoe4-vom-risikogen-zur-genetischen-alzheimer-erkrankung
www.sciencemediacenter.deAPOE4: Vom Risikogen zur genetischen Alzheimer-ErkrankungZwei APOE4-Allele sind, so Studie, nicht nur ein Risikofaktor für eine Alzheimer-Erkrankung, sondern auch die genetische Ursache. Expertinnen & Experten dazu:
Select cases of Alzheimer's may be linked to carrying two copies of a gene in new research #alzheimers #research #study #memorycar #dementia #gene #apoe4 #genetics #dna
https://fullsteamahead365.com/2024/05/07/alzheimers-may-be-linked-to-two-copies-of-gene/
fullSTEAMahead365 · Select cases of Alzheimer's may be linked to carrying two copies of a gene in new research - fullSTEAMahead365The research shows that people carrying two copies of a particular gene are more likely to have Alzheimer’s.
Via #ABC News
Scientists have long known a #gene called #APOE4 is one of many things that can increase people’s risk for #Alzheimers, including simply getting older. The vast majority of Alzheimer’s cases occur after age 65. But #research published Monday suggests that for people who carry not one but two copies of the gene, it's more than a risk factor, it's an underlying cause of the mind-robbing #disease.
ABC News · A gene long thought to just raise the risk for Alzheimer's may cause some cases
People with 2 copies of APOE4 were known to have a high risk of #Alzheimers.
Today that changed to nearly 100% full penetrance
Buenas noticias, nueva avenida terapéutica para prevenir el desarrollo de la Enfermedad de #Alzheimer, incluso (sobre todo) en portadores de #ApoE4
En los próximos años habrá nuevos intentos de tratamiento, excelentes noticias!
PubMedRare genetic variation in fibronectin 1 (FN1) protects against APOEε4 in Alzheimer's disease - PubMedThe risk of developing Alzheimer's disease (AD) significantly increases in individuals carrying the APOEε4 allele. Elderly cognitively healthy individuals with APOEε4 also exist, suggesting the presence of cellular mechanisms that counteract the pathological effects of APOEε4; however, these mechani …
Common Alzheimer’s disease gene may have helped our ancestors have more kids
Study of traditional society in Amazon suggests why evolution hasn’t purged harmful variant
https://www.science.org/content/article/common-alzheimer-s-disease-gene-may-have-helped-our-ancestors-have-more-kids
#alzheimers #genetics #population #APOE4
Predictors of longitudinal cognitive ageing from age 70 to 82 including #APOEe4 status, early-life and #lifestyle factors: the Lothian Birth Cohort 1936
APOE4 status explains the majority of variance in cognitive aging (but not much in a verbal domain) when early-life and lifestyle factors are included in the same model.
(Open Access)
https://www.nature.com/articles/s41380-022-01900-4
Replied in thread
@philshapiro NIH Study reveals how APOE4 gene may increase risk for dementia - women are at higher risk of inheriting this gene from each parent thus increasing the risk by 8 to 10 times. https://www.nih.gov/news-events/nih-research-matters/study-reveals-how-apoe4-gene-may-increase-risk-dementia #Dementia #APOE4 #gene Take #Cholinesupplements
National Institutes of Health (NIH)Study reveals how APOE4 gene may increase risk for dementiaResearchers found that the APOE4 gene may increase the risk of developing Alzheimer’s disease and other dementias by altering brain cells’ lipid metabolism.
This is really intriguing - but it's VERY early in development. And if this tx is dangerous and/or staggeringly expensive, determing benefit of reducing lifetine risk from say 30-55% to 20% is going to be complicated. #Alzheimers #APOE4
Alzheimer’s APOE4 Genetic Risk Targeted in Promising Trial.
https://www.nytimes.com/2022/12/02/health/alzheimers-apoe4-gene-therapy.html
www.nytimes.comAlzheimer’s APOE4 Genetic Risk Targeted in Promising Trial
It’s well-known that carrying one copy of the #APOE4 gene variant increases one’s risk for #Alzheimer’s disease threefold and two copies about tenfold, but the fundamental reasons why, and what can be done to help patients, remain largely unknown
#Neuroscience #sflorg
https://www.sflorg.com/2022/11/ns11222202.html
www.sflorg.comAlzheimer’s risk gene undermines insulation of brain’s “wiring”In people carrying APOE4, a key brain cell mismanages cholesterol needed to insulate neurons properly
The #APOE4 gene variant is the strongest genetic risk factor for #Alzheimer disease. However, the effects of APOE4 on the human brain are not fully understood. A new study suggests that this risk gene may undermine insulation of the brain's wiring, opening opportunities to develop targeted therapies.
https://www.nature.com/articles/s41586-022-05439-w
News and views:
https://twitter.com/DrLiHueiTsai/status/1593082131449716736?s=20&t=Ec-nCdyjXknQ3WtWj24zYw
NatureAPOE4 impairs myelination via cholesterol dysregulation in oligodendrocytes - NatureAPOE4 is associated with widespread gene expression changes across all cell types of the human brain, altered cholesterol homeostasis and transport signalling pathways, and decreased myelination in the brain.
Continued thread
Silvia’s poster (Monday morning, D51) shows how switching on #betaamyloid production in mice decreases neuronal and vascular responses to visual stimulation and reduces blood oxygenation, especially in #APOE4 mice. It's the first data out of a mega project and we'd love to hear what you think! 2/3