Are you ready for #EMBLEpitrans? Prepare to deep dive into advances in RNA modification functions, their key roles in gene expression, disease, and transformative therapies. Be part of the community
Submit your abstract by 5 August
28 – 30 October
EMBL Heidelberg and Virtual
https://s.embl.org/etc25-01-ma
#RNAmodification is responsible for the disruption of #mitochondrial protein synthesis in #Alzheimers disease: #Methylation of #mRNA disturbs the production of ND5, a subunit of complex I of the respiratory chain / Impairment of the brain's energy supply
https://nachrichten.idw-online.de/2024/04/25/rna-modification-is-responsible-for-the-disruption-of-mitochondrial-protein-synthesis-in-alzheimer-s-disease
#RNAmodification is responsible for the disruption of #mitochondrial protein synthesis in #Alzheimers disease: #Methylation of #mRNA disturbs the production of ND5, a subunit of complex I of the respiratory chain / Impairment of the brain's energy supply
https://nachrichten.idw-online.de/2024/04/25/rna-modification-is-responsible-for-the-disruption-of-mitochondrial-protein-synthesis-in-alzheimer-s-disease
It's nice to see, from time to time, a negative result getting published. The title is quite clear (although m6A is not very abundant in 5' untranslated regions):
"N6-methyladenosine in 5′ UTR does not promote translation initiation"
pdf link:
https://www.cell.com/molecular-cell/pdf/S1097-2765(23)01074-2.pdf
This is cool:
"Direct sequencing of total Saccharomyces cerevisiae tRNAs by LC–MS/MS"
Very interesting paper from Schraga Schwartz (in our department) and his student Anna Uzonyi (who won best talk at the latest Israeli #RNA society meeting for presenting this work).
#m6A is an #RNAmodification regulating #mRNADegradation.
They show that m6A is deposited on all #mRNA molecules by default, but is excluded in the vicinity of splice junctions by EJC.
So m6A or lack of it is a memory of nuclear processing.
https://www.cell.com/molecular-cell/fulltext/S1097-2765(22)01205-9
How does N6-methylA (m6A) #RNAmodification influence lncRNAs? @DrPorman @ChromaTownie &co show that the #lncRNA HOTAIR represses or activates genes, depending on a single #m6A modification, to affect #BreastCancer cell biology @rnabioco #PLOSBiology https://plos.io/3VzO5ZT
How does N6-methylA (m6A) #RNAmodification influence lncRNAs? @DrPorman @ChromaTownie &co show that the #lncRNA HOTAIR represses or activates genes, depending on a single #m6A modification, to affect #BreastCancer cell biology @rnabioco #PLOSBiology https://plos.io/3VzO5ZT
How does N6-methylA (m6A) #RNAmodification influence lncRNAs? @DrPorman @ChromaTownie &co show that the #lncRNA HOTAIR represses or activates genes, depending on a single #m6A modification, to affect #BreastCancer cell biology @rnabioco #PLOSBiology https://plos.io/3VzO5ZT
