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#circadianrhythms

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Epigenetics Podcast

In our most recent episode Dr. Raffaele Teperino joined us for a deep dive into how paternal health before conception impacts offspring and maternal outcomes.

We explore epigenetics, circadian rhythms, seminal fluid signaling, and metabolic programming—challenging long-held views on intergenerational health.

Listen here: activemotif.com/podcasts-raffa
#Epigenetics #PaternalHealth #SciencePodcast #CircadianRhythms #MetabolicHealth

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Mehran Akhtar

Here is my first post on Mastadoom.

Had a fantastic time presenting my PhD research on neurogenetics at the UK Clock Club Meeting! It was a great opportunity to share my work on genetic influences on circadian rhythms and engage in insightful discussions with experts in the field.

Grateful for the valuable feedback and inspiring conversations—excited to take these ideas forward in my research!
@kofanchen

#UKClockClub #Neurogenetics #CircadianRhythms #PhDResearch #Sleep”

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michael

12-JUL-2024
Melanopsin DNA aptamers can regulate input signals of mammalian #CircadianRhythms by altering the phase of the molecular clock
#DNAaptamers Melapts to wake up refreshed in the morning.

eurekalert.org/news-releases/1 #science #LightAndLife

EurekAlert!Melanopsin DNA aptamers can regulate input signals of mammalian circadian rhythms by altering the phase of the molecular clockDNA aptamers of melanopsin that regulate the clock hands of biological rhythms were developed by the Toyohashi University of Technology and the National Institute of Advanced Industrial Science and Technology (AIST) group.   DNA aptamers can specifically bind to biomolecules to modify their function, potentially making them ideal oligonucleotide therapeutics. We screened the DNA aptamer melanopsin (OPN4), a blue light photopigment in the retina that plays a key role in the use of light signals to reset the phase of circadian rhythms in the central clock. First, 15 DNA aptamers of melanopsin (Melapts) were identified following eight rounds of Cell-SELEX using cells expressing melanopsin on the cell membrane. Subsequent functional analysis of each Melapt was performed in a fibroblast cell line stably expressing both Period2:ELuc and melanopsin by determining the degree to which they reset the phase of mammalian circadian rhythms in response to blue light stimulation. Period2 rhythmic expression over a 24-h period was monitored in Period2:ELuc: thymidine kinase (TK):OPN4 stable fibroblasts expressing melanopsin. At subjective dawn, four Melapts were observed to advance their phase by >1.5 h, whereas seven Melapts delayed their phase by >2 h. A few Melapts caused a phase shift of approximately 2 h, even in the absence of photostimulation, presumably because Melapts can only partially affect input signaling for the phase shift. Additionally, a few Melaps-induced phase shifts in Period1::luc transgenic (Tg) mice were used to monitor circadian rhythms by Period1 rhythmic expression. These DNA aptamers may have the capacity to affect melanopsin in vivo. In summary, Melapts aptamers can successfully regulate the input signal and the shifting phase (both phase advance and phase delay) of mammalian circadian rhythms in vitro and in vivo. DNA aptamers of melanopsin that regulate the clock hands of biological rhythms were developed by the Toyohashi University of Technology and the National Institute of Advanced Industrial Science and Technology (AIST) group.   DNA aptamers can specifically bind to biomolecules to modify their function, potentially making them ideal oligonucleotide therapeutics. We screened the DNA aptamer melanopsin (OPN4), a blue light photopigment in the retina that plays a key role in the use of light signals to reset the phase of circadian rhythms in the central clock. First, 15 DNA aptamers of melanopsin (Melapts) were identified following eight rounds of Cell-SELEX using cells expressing melanopsin on the cell membrane. Subsequent functional analysis of each Melapt was performed in a fibroblast cell line stably expressing both Period2:ELuc and melanopsin by determining the degree to which they reset the phase of mammalian circadian rhythms in response to blue light stimulation. Period2 rhythmic expression over a 24-h period was monitored in Period2:ELuc: thymidine kinase (TK):OPN4 stable fibroblasts expressing melanopsin. At subjective dawn, four Melapts were observed to advance their phase by >1.5 h, whereas seven Melapts delayed their phase by >2 h. A few Melapts caused a phase shift of approximately 2 h, even in the absence of photostimulation, presumably because Melapts can only partially affect input signaling for the phase shift. Additionally, a few Melaps-induced phase shifts in Period1::luc transgenic (Tg) mice were used to monitor circadian rhythms by Period1 rhythmic expression. These DNA aptamers may have the capacity to affect melanopsin in vivo. In summary, Melapts aptamers can successfully regulate the input signal and the shifting phase (both phase advance and phase delay) of mammalian circadian rhythms in vitro and in vivo.
Public
Hari Tulsidas

Recent research emphasizes the significant impact of aligning cancer immunotherapy with the circadian clock. This approach optimizes treatment effectiveness and reduces side effects by synchronizing therapies with the body’s natural rhythms. Integrating circadian biology into cancer treatment represents a significant leap forward in personalized and patient-centered healthcare.

#CancerTreatment #Immunotherapy #CircadianRhythms #PersonalizedMedicine

sciencedaily.com/releases/2024.

Public
DoomsdaysCW

Why #LightPollution is a solvable #environmental crisis

Excessive #OutdoorLighting is deadly to #animals and takes a toll on #HumanHealth and wellbeing, too. But when it comes to large-scale environmental problems, this one may be a relatively easy fix.

By Alissa Greenberg
Friday, April 1, 2022

"In recent decades, lightbulbs made with #LEDs arrived, a revolution in energy efficiency with seemingly little downside. After all, an #LED bulb converts some 90% of the electricity it uses into light, whereas a conventional incandescent bulb only converts about 10%. And LED bulbs are touted as lasting up to 25 times longer.

"But the physics of LEDs make them fundamentally different from incandescents. While those traditional bulbs put out warm white light made of all colors mixed together, LEDs filter blue-rich light through a specialized phosphor material, producing light that appears white to the human eye but is still more blue-intense than incandescents’ light.

"But #BlueLight is also the most disruptive to our #nighttime environment because it mimics daylight, disrupting the hormone production and sleep cycles of both animals and humans.

"#Melatonin, one of those hormones, helps the immune system destroy renegade cells dividing out of control. That can lead to other health issues, including heightened rates of #cancer. And, 'we’re not the only ones who produce melatonin,' says Mario Motta, a cardiologist and trustee of the American Medical Association. Even amoebae produce melatonin'—meaning even amoebae might be vulnerable to light at night.

"The impacts of light pollution are evident everywhere from human health to astronomy research, but they come into particular focus in the recent phenomenon of global species #dieoffs. Between 100 million and a billion birds die every year due to light pollution, according to Massachusetts IDA chapter president James Lowenthal. New York City recently dealt with a huge die-off, 'with flocks of #MigratoryBirds slamming into buildings,' says Sarah Bois, an ecologist at the island’s Linda Loring Nature Foundation and a member of Nantucket Lights. 'They’re attracted to light.' A 2015 study at New York’s 9/11 'Tribute in Light'' installation showed an increase from 500 birds within half a kilometer of the light beams before they were turned on to 15,700 just minutes after.

"The issue is a double whammy for birds because they rely on #insects for food—and those populations are plummeting, with light pollution contributing significantly to the so-called "#InsectApocalypse.” By some estimates, one third of insects attracted to light sources at night die before morning, either due to exhaustion or because they get eaten. And according to a study in Germany, the number of insects in that country alone that die after being attracted to lights can number 100 billion or more in a single summer.

"Some starve to death searching for food that should appear bluer at twilight but is lit up amber under streetlights, says insect conservationist Avalon Owens, a doctoral candidate at Tufts University. Some are thrown off by light just the way we are, because of their #CircadianRhythms. #Pollinators whose schedules are altered by artificial light miss the #flowers they’re evolutionarily paired with, if the flowers naturally close and open with the warmth of the sun. And insects that rely on circadian rhythms for their yearly development don’t hibernate in time for winter and freeze to death.

"On #Nantucket, these phenomena are of particular concern because the island is home to a remarkably healthy population of northern long-eared #bats, which are endangered. Like many birds, the bats rely on insects for food and are easily dazzled by light, putting them in increasing jeopardy. Jack Dubinsky, director of the Maria Mitchell Aquarium on Nantucket, says he’s concerned that adding increasingly lit-up nights to the challenges of #ClimateChange, water quality, and #ecosystem collapse could put huge pressure on some already struggling species. 'The more curveballs we throw, the less likely they’ll be able to find their way,' he says.

Read more:
pbs.org/wgbh/nova/article/ligh

Nova · Light pollution is an environmental crisis that we can solveBy Alissa Greenberg
#DarkSkies#Extinction#StreetLights
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Lukas VFN 🇪🇺

No two #worms are alike: New study confirms that even the simplest marine organisms tend to be individualistic awi.de/en/about-us/service/pre

Molecular #CircadianRhythms are robust in marine #annelids lacking rhythmic behavior journals.plos.org/plosbiology/

"even simple marine #polychaete worms shape their day-to-day lives on the basis of highly individual rhythms. This diversity is of interest not just for the future of species and populations in a changing environment, but also for medicine."

illustration of worms, old-fashioned clock, and some DNA drawings
Public
Denise G

Understanding the relationship between our sleep, #bodyclock and mental health

Gaining a better understanding of the relationship between #sleep, #circadianrhythms and mental health could unlock new holistic treatments to alleviate #mentalhealth problems.

medicalxpress.com/news/2024-02

Medical Xpress · Understanding the relationship between our sleep, body clock and mental healthBy Science X
Public
Lukas VFN 🇪🇺

How deepest sea dwellers adapted to their environment phys.org/news/2023-06-scientis

Chromosome-level #genome assembly of #HadalSnailfish reveals mechanisms of #DeepSea adaptation in vertebrates elifesciences.org/reviewed-pre

"The complete absence of light in the #HadalZone appears to have had a profound effect on the #fish. The scientists observed a substantial loss of many #genes related to vision. In addition, many genes related to #CircadianRhythms were absent."

Image showing two individual hadal snailfish (Pseudoliparis swirei), the deepest-underwater dwelling vertebrate species on record. By Shunping He.
Public
katch wreck

nature.com/articles/s41586-023

"Cry engages a continuous core of amino-terminal Tim armadillo repeats, resembling how #photolyases recognize damaged DNA, and binds a C-terminal Tim helix, reminiscent of the interactions between light-insensitive #cryptochromes and their partners in mammals..a phosphorylated segment in Tim may impact clock period by regulating the binding of Importin-α and the nuclear import of Tim–Per"

NatureCryptochrome–Timeless structure reveals circadian clock timing mechanisms - NatureStructural analysis of a protein complex in the circadian clock of Drosophila reveals how a light-sensing cryptochrome recognizes and engages its target.
#circadianRhythms#Drosophila#genetics
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