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"Once the requirements were in place, we saw on average a 100% decrease in virus in saliva and up to 12,000% increase in antibody levels to block its spread."

journals.plos.org/plospathogen

journals.plos.orgThe emergence of SARS-CoV-2 lineages and associated saliva antibody responses among asymptomatic individuals in a large university communityAuthor summary Our study identified relationships between specific SARS-CoV-2 (CoV2) variants of concern (VOCs) and CoV2-specific immunoglobulin (Ig) among asymptomatic young adults in our university community. Asymptomatic young adults are important source of CoV2 transmission in the United States of America and other countries. Major findings from our study which we believe inform our understanding of CoV2 transmission and immunity, and may potentially influence COVID monitoring policies at other universities include the following: (1) CoV2 positivity occurred in waves which mirrored those in regions surrounding our university campuses, and were driven by newly emerged VOCs. (2) Only after university vaccine requirements went into effect did net viral loads among all community members decline. (3) Breakthrough infections among vaccinees were not due to an absence of vaccine-elicited Ig, but rather diminished inhibitory capacity during a period when community viral loads peaked. In other words, vaccination efforts achieved their intended goal of increasing CoV2-specific Ig; in individuals with breakthrough infections, however, the capacity of this Ig to inhibit Spike function was limited and corresponded to when community viral loads were at their highest.

"The monitoring program focused on adults for several reasons," Robinson said. "Asymptomatic infections are more common in young adults, asymptomatic individuals would still spread the virus and the isolation of symptomatic individuals alone wasn't enough to flatten the curve of COVID infections."

Auscandoc

The study found in people were not due to an absence of antibodies but depend on at the time of exposure, the ability of the antibodies and the amount of to which the person is .”