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MD @hswapnil@med-mastodon.comwhoah
I had missed this paper from Nature Comm from Freedman, Himmelfarb et al from Seattle
https://www.nature.com/articles/s41467-022-35537-2
Could #Flozination actually reduce cyst growth in #PKD?
yes, mice, organoids etc - but this is a potential U-turn in our understanding
@hswapnil @mike_johansen @Kidney_boy we have whole animal studies that are not as promising. I would like to see more animal and human studies with MRIs
@ChristosArgyrop @mike_johansen @Kidney_boy but PKD patients have been excluded so far
this seems a good set up to do RCTs cautiously of flozins in PKD, right?
@ChristosArgyrop @mike_johansen @Kidney_boy and forgot to tag @Bneuen - are there any Flozin PKD RCTs already ongoing?
@mike_johansen @Kidney_boy @ChristosArgyrop @hswapnil not yet… but they are definitely coming
@ChristosArgyrop @mike_johansen @Kidney_boy @hswapnil will be investigator initiated