datum (n=1)<p><span class="h-card" translate="no"><a href="https://mstdn.ca/@jws" class="u-url mention" rel="nofollow noopener" target="_blank">@<span>jws</span></a></span> <span class="h-card" translate="no"><a href="https://mastodon.social/@MatWright" class="u-url mention" rel="nofollow noopener" target="_blank">@<span>MatWright</span></a></span> </p><p>"All humoral immunities (infection-acquired, vaccine-acquired and hybrid) waned by 3–6 months. Cellular immunity was more durable but showed signs of waning by 6 months." <a href="https://smw.ch/index.php/smw/article/view/3732" rel="nofollow noopener" translate="no" target="_blank"><span class="invisible">https://</span><span class="ellipsis">smw.ch/index.php/smw/article/v</span><span class="invisible">iew/3732</span></a></p><p>That is from 2024, reviewing "205 studies, of which 70 provided data on the duration of protection against SARS-CoV-2 infection" so it's better than any review I could perform, and its references better than anything I could dredge up.</p><p>Back for early Omicron, "relative protection against infection waned from 53.4% a month after vaccination to 16.5% three months after vaccination" <a href="https://www.nature.com/articles/s41467-022-30884-6" rel="nofollow noopener" translate="no" target="_blank"><span class="invisible">https://www.</span><span class="ellipsis">nature.com/articles/s41467-022</span><span class="invisible">-30884-6</span></a></p><p>Then it gets more contentious with damage to the immune system. There are several documented common(!) dysregulations. But if they don't manifest clinically (yet) then is it a problem (yet)?</p><p>Immunology inherently mostly takes time. But now some problems involving the immune system are more common, and "mounting evidence suggests a higher incidence of adverse consequences, such as disruption of the immune system" <a href="https://www.nature.com/articles/s41467-024-47176-w" rel="nofollow noopener" translate="no" target="_blank"><span class="invisible">https://www.</span><span class="ellipsis">nature.com/articles/s41467-024</span><span class="invisible">-47176-w</span></a></p><p>[edit - just juggled links] </p><p><a href="https://zeroes.ca/tags/CovidIsNotOver" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>CovidIsNotOver</span></a> <a href="https://zeroes.ca/tags/SARSCoV2" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>SARSCoV2</span></a> <a href="https://zeroes.ca/tags/waningImmunity" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>waningImmunity</span></a> <a href="https://zeroes.ca/tags/COVID" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>COVID</span></a> <a href="https://zeroes.ca/tags/COVID19" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>COVID19</span></a> <a href="https://zeroes.ca/tags/immunology" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>immunology</span></a> <a href="https://zeroes.ca/tags/SwissCheeseModel" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>SwissCheeseModel</span></a> <a href="https://zeroes.ca/tags/maskUp" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>maskUp</span></a> <a href="https://zeroes.ca/tags/cleanAIr" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>cleanAIr</span></a></p>