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#vcjd

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Giuseppe Michieli<p>Isolation of a novel <a href="https://mstdn.science/tags/human" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>human</span></a> <a href="https://mstdn.science/tags/prion" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>prion</span></a> <a href="https://mstdn.science/tags/strain" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>strain</span></a> from a PRNP codon 129 heterozygous <a href="https://mstdn.science/tags/vCJD" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>vCJD</span></a> <a href="https://mstdn.science/tags/patient" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>patient</span></a>, <a href="https://etidiohnew.blogspot.com/2025/02/isolation-of-novel-human-prion-strain.html" rel="nofollow noopener noreferrer" translate="no" target="_blank"><span class="invisible">https://</span><span class="ellipsis">etidiohnew.blogspot.com/2025/0</span><span class="invisible">2/isolation-of-novel-human-prion-strain.html</span></a></p>
VeganPizza69 ⓋⒶ<p>2/3</p><p>So when do we expect hunters to start dying from prion diseases? I don't think we'll know. It's going to be a surprise. With all the things tied to dementia now, it may just be one part of a complex causal pathway, a comorbidity. </p><p>Here's a nice microbiology podcast that goes a bit into prions: <a href="https://www.microbe.tv/twiv/twiv-878/" rel="nofollow noopener noreferrer" translate="no" target="_blank"><span class="invisible">https://www.</span><span class="">microbe.tv/twiv/twiv-878/</span><span class="invisible"></span></a> </p><p>Here's a paper that shows that CWD can get into humans: <a href="https://link.springer.com/article/10.1007/s00401-022-02482-9" rel="nofollow noopener noreferrer" translate="no" target="_blank"><span class="invisible">https://</span><span class="ellipsis">link.springer.com/article/10.1</span><span class="invisible">007/s00401-022-02482-9</span></a> (unfortunately, tested on mice)</p><p>&lt;💬&gt;<br>Notably, our data suggest a different clinical presentation, prion signature, and tissue tropism, which causes challenges for detection by current diagnostic assays. Furthermore, the presence of infectious prions in feces is concerning because if this occurs in humans, it is a source for human-to-human transmission. These findings have strong implications for public health and CWD management.<br>&lt;/💬&gt;</p><p>Here's another study: <a href="https://wwwnc.cdc.gov/eid/article/24/8/16-1888_article" rel="nofollow noopener noreferrer" translate="no" target="_blank"><span class="invisible">https://</span><span class="ellipsis">wwwnc.cdc.gov/eid/article/24/8</span><span class="invisible">/16-1888_article</span></a></p><p>&lt;💬&gt;<br>elk CWD prions could convert human PrPC from human brain and could also convert recombinant human PrPC expressed in transgenic mice and eukaryotic cell cultures<br>&lt;/💬&gt;</p><p><a href="https://veganism.social/tags/vCJD" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>vCJD</span></a> <a href="https://veganism.social/tags/CWD" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>CWD</span></a></p>
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