ѦਹѤʞ Novel keyhole technique used to remove head tumour:
https://www.bbc.com/news/articles/c98yg1n9j83o
#medical #surgery #operation #tumour #cranium #medicine
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"Researchers from RMIT University in Australia and Indian institutions unveiled a novel gold-based drug that shows significant promise in the fight against cancer. The drug has demonstrated the ability to slow #tumour growth while selectively targeting cancer cells more effectively than traditional #chemotherapy agents."
https://interestingengineering.com/health/gold-based-drug-slows-cancer
Interesting EngineeringNew gold-based drug shrinks cancer by 82%, outperforms chemoA new gold-based drug slows tumor growth by 82% in animals and targets cancer cells more precisely than chemotherapy.
"By using time-resolved analyses of scRNA-seq data, we determined the potential transitional trajectories of tumor cells and identified the metastasis-initiating subpopulations"
https://link.springer.com/article/10.1007/s11684-024-1081-7
Reading right now. The identification of cells that initiate #metastasis are of interest, although n=2 paired primary and #BoneMarrow samples may be a bit limited.
SpringerLinkSingle-cell RNA-seq reveals the transcriptional program underlying tumor progression and metastasis in neuroblastoma - Frontiers of MedicineNeuroblastoma (NB) is one of the most common childhood malignancies. Sixty percent of patients present with widely disseminated clinical signs at diagnosis and exhibit poor outcomes. However, the molecular mechanisms triggering NB metastasis remain largely uncharacterized. In this study, we generated a transcriptomic atlas of 15 447 NB cells from eight NB samples, including paired samples of primary tumors and bone marrow metastases. We used time-resolved analysis to chart the evolutionary trajectory of NB cells from the primary tumor to the metastases in the same patient and identified a common ‘starter’ subpopulation that initiates tumor development and metastasis. The ‘starter’ population exhibited high expression levels of multiple cell cycle-related genes, indicating the important role of cell cycle upregulation in NB tumor progression. In addition, our evolutionary trajectory analysis demonstrated the involvement of partial epithelial-to-mesenchymal transition (p-EMT) along the metastatic route from the primary site to the bone marrow. Our study provides insights into the program driving NB metastasis and presents a signature of metastasis-initiating cells as an independent prognostic indicator and potential therapeutic target to inhibit the initiation of NB metastasis.
www.nature.comThis kids’ brain cancer is incurable — but immune therapy holds promiseCAR-T therapy, which harnesses a person’s own immune cells, racks up some astonishing success stories against deadly brain tumours in children.
Ancient Egyptians tried to treat cancer 4,000 years ago, cut-marked skull indicates
https://www.livescience.com/archaeology/ancient-egyptians/ancient-egyptians-tried-to-treat-cancer-4000-years-ago-cut-marked-skull-indicates #archaeology #egypt #medicine #cancer #surgery #tumour
Live Science · Ancient Egyptians tried to treat cancer 4,000 years ago, cut-marked skull indicates
Impressive new work by Moravec et al. in Nature Biotechnology, sadly not open source. "... a #HighThroughput personalized #TCR discovery pipeline ..." with which they "...identified dozens of CD4+ and CD8+ T-cell-derived TCRs with potent tumor reactivity, including TCRs that recognized patient-specific #neoantigens."
NatureDiscovery of tumor-reactive T cell receptors by massively parallel library synthesis and screening - Nature BiotechnologyTumor-specific T cell receptors (TCRs) are identified by functional screening of synthetic TCR libraries.
#Tasmaniandevil facial #tumour hasn’t let up https://cosmosmagazine.com/nature/animals/tasmanian-devil-facial-tumour-study/
In 2021, a study showed that 25 years of #DFTD’s spread had a massive impact on the Tasmanian devil population. The number of devils on the island of Tasmania shrank from 53,000 in 1996 to only 17,000 in 2021. The same study suggested that DFTD covered more than 90% of the devils’ range in Tasmania. As a result, #Australia’s largest remaining marsupial carnivore was listed as endangered.
Cosmos · Tasmanian devil facial tumour hasn't let upA study which claimed Tasmanian devil facial tumour transmission was slowing has been called into question by new research.
Anyone who supports me to pay for services and assistance that are not covered by insurance in order to at least take away my financial worries while fighting my cancer can do so here:
My Amazon Wishlist:
https://www.amazon.de/hz/wishlist/ls/MLYVBXM60LR6?ref_=wl_share
My GoFoundMe Page:
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My Paypal Account:
https://www.paypal.com/pools/c/92opGMV4OB
Of course and that would be much more appreciate if you like and share my posts.
Thank you very much for any support.
Roland
We have a brand new article from David Gutmann and colleagues at #WashingtonUniversitySchoolofMedicine on the application of human stem cell engineering to #NervousSystem #tumour modelling and how this affords unique opportunities to study the cellular origins of tumours, examine cancer evolution and identify future therapeutic targets
https://journals.biologists.com/dmm/article/17/2/dmm050533/343065/
Forget lung, breast or prostate cancer: why tumour naming needs to change
https://www.nature.com/articles/d41586-024-00216-3 #cancer #tumour #metastatic#organ #oncology #treatment #nomenclature #classification
www.nature.comForget lung, breast or prostate cancer: why tumour naming needs to changeThe conventional way of classifying metastatic cancers according to their organ of origin is denying people access to drugs that could help them.
Continued thread
Emily & I saw her neurosurgeon this afternoon. After discussing the last month's worth of investigations & the brain #tumour itself, Emily will proceed to surgery within the next month. We've time to think about it but, with her MS status as it is, there's likely not going to be a better opportunity than now. So, Emily will call and discuss a date for surgery with the secretary tomorrow. Mid Feb. is looking likely.
We were teary last night. The gravity of all this is hitting her hard & we're trying to shed our Nursing skins & see this through the patient lens. We've made a lot of phone calls this morning to organise things. Em has a quandary in that b/c of her MS, she requires #Ocrevus infusions 6 monthly. To have the surgery on her brain tumour, it's likely she'll have to forego her Jan. round of Ocrevus to spare her immune system to handle the surgery. Of course, there's an implication here for her MS. Ocrevus holds the MS steady. Without it, it's a bit of an unknown.
The clinician in me thinks it will likely be negligible. The husband in me does however, worry. So that's a thing this morning...
Delighted that our #cancer #research has been selected for the cover image of December’s Life Science Alliance! In our article we show how gain of function mutations to the #ionchannel KCNQ3 may promote #tumour growth in oesophageal adenocarcinoma
Breast cancer often spreads to the spine — newfound stem cell can explain why
A stem cell that contributes to vertebra formation also encourages the growth of tumours that move to the backbone from elsewhere.
https://www.nature.com/articles/d41586-023-02851-8 #breast #cancer #metastasis #vertebrae #tumour #protein #MFGE8 #StemCells #vSSCs
www.nature.comBreast cancer often spreads to the spine — newfound stem cell can explain whyA stem cell that contributes to vertebra formation also encourages the growth of tumours that move to the backbone from elsewhere.
A great read on #DrugResistance in #cancer, in Nature, by Vasan, Baselga, and Hyman. Sure, 2019 is four years ago, so there will be updates, e.g. on mapping #CancerDependency or the role of #ctDNA in early detection or monitoring. But the framework for understanding drug resistance is here.
https://www.nature.com/articles/s41586-019-1730-1
Although it doesn't say it, I think it may be #OpenAccess since I'm not logged in to my institution right now but can reach full text anyway.
NatureA view on drug resistance in cancer - NatureA review of drug resistance in cancer analyses each biological determinant of resistance separately and discusses existing and new therapeutic strategies to combat the problem as a whole.
#Radiomic signatures from T2W and DWI MRI are predictive of #tumour hypoxia in colorectal #liver metastases. (Zuhir Bodalal et al.)
https://insightsimaging.springeropen.com/articles/10.1186/s13244-023-01474-x
“AOH1996 can suppress #tumour growth as a #monotherapy or combination treatment in cell and animal models without resulting in toxicity.
‘The investigational #chemotherapeutic is currently in a Phase 1 clinical trial in humans at City of Hope.’
The researchers have tested AOH1996 in more than 70 #cancer cell lines and several normal control cells. They found the molecule selectively kills cancer cells by disrupting the normal cell reproductive cycle.” https://universeodon.com/@HollyCo26588808/110816274773419698
Universeodon Social MediaHolly (@HollyCo26588808@universeodon.com)#stem #Science #health #USA
Scientists have developed a 'holy grail' molecule that kills all solid cancer tumours, leaving healthy cells unaffected. Can't beat that headline. Phase 1 human trial in progress
https://metro.co.uk/2023/08/01/cancer-cure-pill-treatment-scientists-19228101/?utm_source=fark&utm_medium=website&utm_content=link&ICID=ref_fark
Come and work with us - job opening at the Molenaar research group in the Princess Máxima Center for pediatric oncology, looking for a #bioinformatician / #DataScientist.
Together with my colleagues and me you will research #neuroblastoma, with a focus on #tumour #microenvironment and the #immune compartment using a range of #sequencing data and other high-throughput data.
#CancerResearch #scRNAseq
#FediJobs #JobOffer
For further information, see the vacancy below:
https://werkenbijprinsesmaximacentrum.nl/en/vacancy/bioinformatics-research-scientist/
Werken bij Prinses Maxima CentrumBioinformatics research scientist - Werken bij Prinses Maxima CentrumWhat to expect? The Molenaar group at the Princess Máxima Center aims at the translation of molecular genetic and immunologic knowledge of pediatric solid tumors in new clinical applicable therapeutic interventions. There is a specific […]
My #Information #List is getting heavyweight! So much random factiness my Solo Synthesist is going crazy following leads that appeal to me.
I'm in danger of my head blowing up far sooner than my #Brain #Tumour escaping control!! 
It's wonder-filled this place, a trove of treasures!
"Single-cell transcriptomics reveals immune suppression and cell states predictive of patient outcomes in rhabdomyosarcoma"
Nice new work based on #scRNAseq from our Drost group colleagues at the #PrincessMaximaCenter. a.o., a potential role of #NECTIN3 and #TIGIT in #tumour-induced T cell dysfunction.
https://www.nature.com/articles/s41467-023-38886-8
NatureSingle-cell transcriptomics reveals immune suppression and cell states predictive of patient outcomes in rhabdomyosarcoma - Nature CommunicationsThe cellular differentiation states of paediatric rhabdomyosarcoma (RMS) remain to be explored. Here, single-cell RNA sequencing analysis of RMS tumours reveals an immunosuppressive microenvironment and distinct transcriptional programs predictive of patient outcomes.