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Thiago Carvalho'They identified the 11 most frequently occurring CD4TCRs in mice bearing an autochthonous tumor line. Three TCRs showed evidence of convergent evolution, because T cell clonotypes had different nucleotide sequences but identical TCR α and β chains.' <a href="https://qoto.org/tags/Immunology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Immunology</a> <a href="https://qoto.org/tags/TumorImmunology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#TumorImmunology</a> <a href="https://qoto.org/tags/Immunology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Immunology</a> <a href="https://www.science.org/doi/10.1126/sciimmunol.adp6529" rel="nofollow noopener noreferrer" target="_blank">https://www.science.org/doi/10.1126/sciimmunol.adp6529</a>

Thiago Carvalho"Here, we developed an approach to reprogram tumor cells in vivo by adenoviral delivery of the transcription factors PU.1, IRF8, and BATF3, which enabled them to present antigens as type 1 conventional dendritic cells"<a href="https://qoto.org/tags/Immunology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Immunology</a> <a href="https://qoto.org/tags/TumorImmunology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#TumorImmunology</a> <a href="https://qoto.org/tags/Immunotherapy" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Immunotherapy</a><a href="https://www.science.org/doi/10.1126/science.adn9083" rel="nofollow noopener noreferrer" target="_blank">https://www.science.org/doi/10.1126/science.adn9083</a>

Thiago Carvalho'Here, we analyzed clinical cell and tissue specimens derived from patients presenting with glioblastoma or nonmalignant intracranial disease to report that the cranial bone (CB) marrow, in juxtaposition to treatment-naive glioblastoma tumors, harbors active lymphoid populations at the time of initial diagnosis' <a href="https://qoto.org/tags/Immunology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Immunology</a> <a href="https://qoto.org/tags/TumorImmunology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#TumorImmunology</a> <a href="https://www.nature.com/articles/s41591-024-03152-x" rel="nofollow noopener noreferrer" target="_blank">https://www.nature.com/articles/s41591-024-03152-x</a>

Thiago Carvalho'We have previously demonstrated that excising transcription factor Kruppel-like factor 2 (Klf2) within the T cell lineage blocks the generation of peripheral-derived Tregs (pTregs) without impairing production of thymic-derived Tregs. Using this mouse model, we have now demonstrated that eliminating pTregs is sufficient to delay/prevent tumor malignancy without causing autoimmunity.' <a href="https://qoto.org/tags/Immunology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Immunology</a> <a href="https://qoto.org/tags/TumorImmunology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#TumorImmunology</a> <a href="https://qoto.org/tags/Tregs" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Tregs</a> <a href="https://qoto.org/tags/Immunotherapy" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Immunotherapy</a> <a href="https://www.pnas.org/doi/10.1073/pnas.2404916121" rel="nofollow noopener noreferrer" target="_blank">https://www.pnas.org/doi/10.1073/pnas.2404916121</a>

Thiago Carvalho"Together, our data indicate that GLUT10 is selectively required for glucose uptake of CD8+ T cells and identify that TME accumulated lactic acid inhibits CD8+ T cell effector function by directly binding to GLUT10 and reducing its glucose transport capacity. Last, our study suggests disrupting lactate-GLUT10 binding as a promising therapeutic strategy to enhance CD8+ T cell–mediated antitumor effects." <a href="https://qoto.org/tags/Immunology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Immunology</a> <a href="https://qoto.org/tags/TumorImmunology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#TumorImmunology</a> <a href="https://qoto.org/tags/Immunotherapy" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Immunotherapy</a> <a href="https://www.science.org/doi/10.1126/scitranslmed.adk7399" rel="nofollow noopener noreferrer" target="_blank">https://www.science.org/doi/10.1126/scitranslmed.adk7399</a>

Thiago Carvalho'Late tumors repressed antitumor immunity genes, reducing infiltrating immune cells & tumor–immune cell communications. Innate immune genes, especially interferon-stimulated genes, dominated the list of downregulated tumor genes'<a href="https://qoto.org/tags/Immunology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Immunology</a> <a href="https://qoto.org/tags/TumorImmunology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#TumorImmunology</a> <a href="https://qoto.org/tags/Immunotherapy" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Immunotherapy</a> <a href="https://www.nature.com/articles/s41590-024-01932-8" rel="nofollow noopener noreferrer" target="_blank">https://www.nature.com/articles/s41590-024-01932-8</a>

Thiago Carvalho'The T cell landscape in cancer is well characterized, but the contribution of B cells to anticancer immunosurveillance is less well explored. Here we show an integrative analysis of the B cell and T cell receptor repertoire from individuals with metastatic breast cancer and individuals with early breast cancer during neoadjuvant therapy.'<a href="https://qoto.org/tags/Immunology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Immunology</a> <a href="https://qoto.org/tags/TumorImmunology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#TumorImmunology</a> <a href="https://www.nature.com/articles/s41590-024-01821-0" rel="nofollow noopener noreferrer" target="_blank">https://www.nature.com/articles/s41590-024-01821-0</a>

Thiago Carvalho'Herein, we describe a synapse formation between α-SMA+ CAFs and regulatory T cells (Tregs) in the TME. Foxp3+ Tregs were localized close to α-SMA+CAFs in diverse types of tumor models as well as biopsies from melanoma and colorectal cancer patients.'<a href="https://qoto.org/tags/Immunology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Immunology</a> <a href="https://qoto.org/tags/TumorImmunology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#TumorImmunology</a> <a href="https://www.biorxiv.org/content/10.1101/2023.12.22.572969v1" rel="nofollow noopener noreferrer" target="_blank">https://www.biorxiv.org/content/10.1101/2023.12.22.572969v1</a>

Thiago Carvalho'Here, we use photo-labeling, combined with longitudinal transcriptomic and cellular analyses, to interrogate the fate of intratumoral NK cells. We reveal that NK cells rapidly lose effector functions and adopt a distinct phenotypic state with features associated with tissue residency.' <a href="https://qoto.org/tags/Immunology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Immunology</a> <a href="https://qoto.org/tags/TumorImmunology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#TumorImmunology</a> <a href="https://qoto.org/tags/immunotherapy" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#immunotherapy</a> <a href="https://www.nature.com/articles/s41467-024-44789-z" rel="nofollow noopener noreferrer" target="_blank">https://www.nature.com/articles/s41467-024-44789-z</a>

Thiago Carvalho"Chronic viral infections are known to accelerate immune aging and to induce immune senescence (21, 22). We have shown that among 206 viruses with human tropism, only CMV seropositivity was associated with senescence of CD8+ T cells in patients with aNSCLC." <a href="https://qoto.org/tags/Immunology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Immunology</a> <a href="https://qoto.org/tags/TumorImmunology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#TumorImmunology</a> <a href="https://qoto.org/tags/Immunotherapy" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Immunotherapy</a> <a href="https://www.science.org/doi/full/10.1126/sciadv.adh0708" rel="nofollow noopener noreferrer" target="_blank">https://www.science.org/doi/full/10.1126/sciadv.adh0708</a>

Thiago Carvalho"Animals lacking microglia show increased metastasis, decreased survival and reduced natural killer and T cell responses, showing that microglia are critical to promote anti-tumour immunity to suppress breast cancer brain metastasis." <a href="https://qoto.org/tags/Immunology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Immunology</a> <a href="https://qoto.org/tags/TumorImmunology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#TumorImmunology</a> <a href="https://qoto.org/tags/Microglia" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Microglia</a> <a href="https://www.nature.com/articles/s41556-023-01273-y" rel="nofollow noopener noreferrer" target="_blank">https://www.nature.com/articles/s41556-023-01273-y</a>

Gabriele PollaraCool <a href="https://med-mastodon.com/tags/neuroimmunology" class="mention hashtag" rel="tag">#neuroimmunology</a> paper, linking stress with exhastion of CD8 T cells... <a href="https://med-mastodon.com/tags/immunology" class="mention hashtag" rel="tag">#immunology</a> <a href="https://med-mastodon.com/tags/chronic" class="mention hashtag" rel="tag">#chronic</a> <a href="https://med-mastodon.com/tags/infection" class="mention hashtag" rel="tag">#infection</a> <a href="https://med-mastodon.com/tags/tumorimmunology" class="mention hashtag" rel="tag">#tumorimmunology</a><a href="https://www.nature.com/articles/s41586-023-06568-6?WT.ec_id=NATURE-20231012&utm_source=nature_etoc&utm_medium=email&utm_campaign=20231012&sap-outbound-id=541BD48FBAEAE186648F264640D535396F6E552F" target="_blank" rel="nofollow noopener noreferrer" translate="no">https://www.nature.com/articles/s41586-023-06568-6?WT.ec_id=NATURE-20231012&utm_source=nature_etoc&utm_medium=email&utm_campaign=20231012&sap-outbound-id=541BD48FBAEAE186648F264640D535396F6E552F</a>

Thiago Carvalho'A single intramuscular injection of Lenti-HPV-07 into mice bearing established HPV-induced tumors resulted in complete tumor eradication in 100% of the animals and was also effective against lung metastases.' <a href="https://qoto.org/tags/TumorImmunology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#TumorImmunology</a> <a href="https://qoto.org/tags/Immunology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Immunology</a> <a href="https://qoto.org/tags/immunotherapy" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#immunotherapy</a> Douguet et al <a href="https://sciencemastodon.com/@EmboMolMed" class="u-url mention" rel="nofollow noopener noreferrer" target="_blank">@EmboMolMed</a> <a href="https://www.embopress.org/doi/full/10.15252/emmm.202317723" rel="nofollow noopener noreferrer" target="_blank">https://www.embopress.org/doi/full/10.15252/emmm.202317723</a>

Thiago Carvalho'Here, we show in multiple cancer models that CXCR3+ Treg cells were increased in tumors compared with lymphoid tissues, exhibited an activated phenotype, and interacted preferentially with CXCL9-producing BATF3+ dendritic cells (DCs). Genetic ablation of CXCR3 in Treg cells disrupted DC1-Treg cell interactions and concomitantly increased DC-CD8+ T cell interactions.'<a href="https://qoto.org/tags/Immunology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Immunology</a> <a href="https://qoto.org/tags/TumorImmunology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#TumorImmunology</a> <a href="https://qoto.org/tags/immunotherapy" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#immunotherapy</a> <a href="https://www.cell.com/immunity/fulltext/S1074-7613(23)00260-1" rel="nofollow noopener noreferrer" target="_blank">https://www.cell.com/immunity/fulltext/S1074-7613(23)00260-1</a>

Gabriele PollaraWhen discussing the role of microbiome in modulating immune responses to tumours, I did not expect that to require the actual bacteria translocating to the tumour!<a href="https://med-mastodon.com/tags/TumorImmunology" class="mention hashtag" rel="tag">#TumorImmunology</a> <a href="https://med-mastodon.com/tags/medicine" class="mention hashtag" rel="tag">#medicine</a> <a href="https://med-mastodon.com/tags/immunity" class="mention hashtag" rel="tag">#immunity</a> <a href="https://med-mastodon.com/tags/immunology" class="mention hashtag" rel="tag">#immunology</a> <a href="https://med-mastodon.com/tags/melanoma" class="mention hashtag" rel="tag">#melanoma</a> <a href="https://mstdn.science/@cellpress" class="u-url mention">@cellpress</a> <a href="https://www.cell.com/cell/fulltext/S0092-8674(23)00271-4?dgcid=raven_jbs_etoc_email" target="_blank" rel="nofollow noopener noreferrer" translate="no">https://www.cell.com/cell/fulltext/S0092-8674(23)00271-4?dgcid=raven_jbs_etoc_email</a>

Thiago CarvalhoCool work from Michael Fischbach & collaborators: engineering skin bacteria to express tumoral antigens induces protective T cell responses - including at distal sites (in mice). <a href="https://qoto.org/tags/immunology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#immunology</a> <a href="https://qoto.org/tags/immunotherapy" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#immunotherapy</a> <a href="https://qoto.org/tags/TumorImmunology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#TumorImmunology</a><a href="https://www.science.org/doi/10.1126/science.abp9563" rel="nofollow noopener noreferrer" target="_blank">https://www.science.org/doi/10.1126/science.abp9563</a>

Thiago Carvalho'Thus, identifying the subset of patients for whom public neoantigens are relevant targets is a major challenge. Nevertheless, the ability provided by the expansion of standard-of-care next-generation sequencing to screen patients affords the opportunity for off-the-shelf precision immunotherapies against public neoantigens that would be broadly applicable to many patients and would have tremendous advantages in scalability relative to targeting private neoantigens' <a href="https://qoto.org/tags/Immunology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Immunology</a> <a href="https://qoto.org/tags/Immunotherapy" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Immunotherapy</a> <a href="https://qoto.org/tags/TumorImmunology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#TumorImmunology</a> <a href="https://www.nature.com/articles/s43018-021-00210-y" rel="nofollow noopener noreferrer" target="_blank">https://www.nature.com/articles/s43018-021-00210-y</a>

jobRxivTumor Immunology/Immunotherapy at Wash U @RPachynskiCome join the Pachynski Lab and study <a href="https://mas.to/tags/prostatecancer" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#prostatecancer</a> <a href="https://mas.to/tags/immunotherapy" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#immunotherapy</a> and <a href="https://mas.to/tags/tumorimmunology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#tumorimmunology</a> !!<a href="https://jobrxiv.org/job/washington-university-27778-tumor-immunology-immunotherapy-at-wash-u/?feed_id=41982" rel="nofollow noopener noreferrer" target="_blank">https://jobrxiv.org/job/washington-university-27778-tumor-immunology-immunotherapy-at-wash-u/?feed_id=41982</a><a href="https://mas.to/tags/ScienceJobs" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#ScienceJobs</a> <a href="https://mas.to/tags/job" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#job</a> <a href="https://mas.to/tags/postdoc" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#postdoc</a> <a href="https://mas.to/tags/postdocjobs" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#postdocjobs</a> <a href="https://mas.to/tags/postdocpositions" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#postdocpositions</a> <a href="https://mas.to/tags/immunotherapy" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#immunotherapy</a> <a href="https://mas.to/@Si" class="u-url mention" rel="nofollow noopener noreferrer" target="_blank">@Si</a>... <a href="https://jobrxiv.org/job/washington-university-27778-tumor-immunology-immunotherapy-at-wash-u/?feed_id=41982" rel="nofollow noopener noreferrer" target="_blank">https://jobrxiv.org/job/washington-university-27778-tumor-immunology-immunotherapy-at-wash-u/?feed_id=41982</a>

Thiago Carvalho'In this issue of Nature Medicine, Cascone et al.2share the latest results of their phase 2 platform trial, NEOSTAR, which suggest that the addition of CTLA-4 blockade to neoadjuvant anti-PD-1 plus chemotherapy may augment anti-tumor responses.'<a href="https://qoto.org/tags/LungCancer" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#LungCancer</a> <a href="https://qoto.org/tags/Immunology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Immunology</a> <a href="https://qoto.org/tags/TumorImmunology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#TumorImmunology</a> <a href="https://qoto.org/tags/immunotherapy" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#immunotherapy</a> <a href="https://qoto.org/tags/checkpointinhibitors" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#checkpointinhibitors</a> <a href="https://www.nature.com/articles/s41591-023-02246-2" rel="nofollow noopener noreferrer" target="_blank">https://www.nature.com/articles/s41591-023-02246-2</a>

Thiago Carvalho"Here, we show that glycolysis drives STING signaling to facilitate DC-mediated antitumor immune responses. Tumor-infiltrating DCs exhibited elevated glycolysis, and blockade of glycolysis by DC-specific Ldha/Ldhb double deletion resulted in defective antitumor immunity." <a href="https://qoto.org/tags/Immunology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Immunology</a> <a href="https://qoto.org/tags/TumorImmunology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#TumorImmunology</a> <a href="https://qoto.org/tags/Immunotherapy" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Immunotherapy</a> <a href="https://qoto.org/tags/Metabolism" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Metabolism</a> <a href="https://qoto.org/tags/InnateImmunity" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#InnateImmunity</a><a href="https://www.jci.org/articles/view/166031" rel="nofollow noopener noreferrer" target="_blank">https://www.jci.org/articles/view/166031</a>

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