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#sequelae

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Paul Sochacki

I wonder if all these #radiocommercials I'm hearing for exocrine pancreatic insufficiency (EPI) are related to #SARScov2. I seem to recall #pancreas damage being one of the particularly pesky features of #sequelae (viral persistence), in at least some people.

I remember thinking this was chilling for relying on repurposed HIV drugs for treatment, because they rely on the pancreas to break them down. Like, assuming Long COVID treatment in the US and global West starts getting more attention.

Is anyone else hearing these #EPI commercials too? Clearly I'm obsessed, but it's... suspicious. Tests for EPI were fairly uncommon in lab, relied on examining a piece of poo for diagnosis. The positives always looked really freakish.

Paul Sochacki

It's sad occasionally popping onto any other social media platform (Reddit, Insta, Xitter) and still seeing vax misinfo being spread years after the mandates ended, highlighting how little #publichealth has done to educate the public and family health practitioners about viral #sequelae. So much trust has been lost in US-ian scientific and medical institutions over the last few years, I fear the damage is irreparable. We are undoing decades worth of advances in #preventivemedicine.

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Paul Sochacki, MS

So per wastewater we're apparently infecting around 2M (or 0.5% of the population (2M/335M)) with #SarsCoV2 per day. Excluding coinfection with multiple immune evasive variants as a confounder, that's about 0.05-0.1% of the population predicted to be maimed with long term #sequelae, depending on which model you look at.

Conservative opinions place LC prevalence at 5-8% (Ashish Jha's comments) while others have cited up to 20% (CDC).

That's an awful lot of sequelae. Daily. #MaskUpIndoors

Replied in thread
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James Harris :laserkiwi:

24% of people have "smell or taste disorder” after covid. ''Interestingly, ... smell or taste disorder was the cluster with the weakest co-occurrence with any other symptom cluster'' bmj.com/content/379/bmj-2022-0

And it goes away within 2 years ( recent article, lost the ref)

@JimmyKip @tcnicholls #covid #sequelae #taste

The BMJ · Post-acute sequelae of covid-19 six to 12 months after infection: population based studyObjectives To describe symptoms and symptom clusters of post-covid syndrome six to 12 months after acute infection, describe risk factors, and examine the association of symptom clusters with general health and working capacity. Design Population based, cross sectional study Setting Adults aged 18-65 years with confirmed SARS-CoV-2 infection between October 2020 and March 2021 notified to health authorities in four geographically defined regions in southern Germany. Participants 50 457 patients were invited to participate in the study, of whom 12 053 (24%) responded and 11 710 (58.8% (n=6881) female; mean age 44.1 years; 3.6% (412/11 602) previously admitted with covid-19; mean follow-up time 8.5 months) could be included in the analyses. Main outcome measures Symptom frequencies (six to 12 months after versus before acute infection), symptom severity and clustering, risk factors, and associations with general health recovery and working capacity. Results The symptom clusters fatigue (37.2% (4213/11 312), 95% confidence interval 36.4% to 38.1%) and neurocognitive impairment (31.3% (3561/11 361), 30.5% to 32.2%) contributed most to reduced health recovery and working capacity, but chest symptoms, anxiety/depression, headache/dizziness, and pain syndromes were also prevalent and relevant for working capacity, with some differences according to sex and age. Considering new symptoms with at least moderate impairment of daily life and ≤80% recovered general health or working capacity, the overall estimate for post-covid syndrome was 28.5% (3289/11 536, 27.7% to 29.3%) among participants or at least 6.5% (3289/50 457) in the infected adult population (assuming that all non-responders had completely recovered). The true value is likely to be between these estimates. Conclusions Despite the limitation of a low response rate and possible selection and recall biases, this study suggests a considerable burden of self-reported post-acute symptom clusters and possible sequelae, notably fatigue and neurocognitive impairment, six to 12 months after acute SARS-CoV-2 infection, even among young and middle aged adults after mild infection, with a substantial impact on general health and working capacity. Trial registration German registry of clinical studies DRKS 00027012. Data from EPILOC phase 1 are available for research purposes upon request from the corresponding author at winfried.kern@uniklinik-freiburg.de.
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Chris Hall

For people not hospitalized when they got covid, substantial risk remains 2 years later for several major organ systems such as gastrointestinal, musculoskeletal and neurologic systems (Aug 2023). [most (90%) of the study cohort was men]

Updated my covid19 resource page to include that study (under the "General" heading).

#Covid #Covid19 #CovidSequelae #sequelae #LongCovid #COVIDisAirborne

christopher-james-hall.com/cov

Platform JournalismLong Covid Research and News Coverage — Platform JournalismLong Covid Research and media overview. Summary of the research into chronic illness resulting from Covid-19 infections. Examples of news coverage of long covid issues.
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