Nick Mark, MD @nick

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**datum (n=1)** @datum@zeroes.ca · Apr 1

Apr 1

datum (n=1) @datum@zeroes.ca

@DenisCOVIDinfoguy they also cite https://pubmed.ncbi.nlm.nih.gov/35810238/

which has this absolute adjective of a hypothesis:

SARS-CoV-2 may bind to ACE2 in order to enter the host brainstem cell and change baroreflex sensitivity

because

The integral parts of the brain renin-angiotensin system, as ACE2 enzyme, are highly expressed in the brainstem, which may also be involved in baroreflex sensitivity, playing an important role in HRV.

which would help explain POTS!!

PubMedPotential autonomic nervous system dysfunction in COVID-19 patients detected by heart rate variability is a sign of SARS-CoV-2 neurotropic features - PubMedIncreasing evidence strongly support that the newly identified severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) leads to the development of COVID-19-associated central nervous system (CNS) manifestations. The presence of SARS-CoV-2 viral protein in the brainstem, which includes cardiovas …

#COVID #COVID19 #SARS2

Continued thread

**sport of sacred spherical cows** @beadsland@hcommons.social · Apr 1 *

Apr 1 *

sport of sacred spherical cows @beadsland@hcommons.social

Updated #CDC estimates show we've pretty much been in a JN.1.11 soup since Dec, until late March, when LP.8.1 took majority.

Data collection continues to be a low priority nationally, as only one region (NY/NJ) has enough data for CDC to plot.

No new variants broken out, yet CDC seems to have resources to tailor their color key: https://hcommons.social/@beadsland/114163320179234281

Raj's dashboard was updated on Sunday.

❖ #ThisIsOurPolio #Covid #Covid19 #SARS2 #variants #CovidIsNotOver #CovidIsAirborne #dataviz #datavis

Chart: Estimated U.S. Variant Proportions by Common Name
Sources: Centers for Disease Control, CoV-Lineages, NYITCOM Research, Daniele Focosi, World Health Network, others

[ beadsland on Ko-fi ]

Reskin of CDC's Variants Nowcast, and any significant variants in GISAID not broken out by CDC.

Five bar-style tree-charts, for fortnights through March 16–29. Legend of last fortnight, organized by subheadings of color-grouped families and convergent clusters. Percentages overlay each color key, reflecting share as of most recent tree-chart.

Essentially all WHO-Vaccine-Target JN.1. LP.8.1 accounts for well over half; JN.1 + FLiRT for over a quarter.

For fortnight of 3/2–3/15, packed bubble charts fill single-variant tiles, indicating diversification of those variants (per GISAID) that wouldn't otherwise be apparent from CDC's Nowcast.

Legend:

LP.8.1 [purple]:
55% - LP.8.1.1 / NY† & other LP.8.1

XEC [browns]:
21% - XEC.2† & other XEC
2% - XEC.4

JN.1.11 + FLuQE [greens]:
6% - MC.10.1 & MC.19
3% - MC.28.1
2% - XEQ
4% - MC.1 & other KP.3.1.1 / MC
⅘% - other KP.3

JN.1 + FLiRT [reds]:
4% - LF.7
2% - LB.1.3.1 / NL

JN.1.11 + FLiRT [blues]:
½% - XEK
0% - KP.2.3 & KP.1.1.3 / LP

Other [greys]:
⅖% - JN.1.16
⅙% - other WHO-Vaccine-Target JN.1
0% - Other (not specified)

† Dagger variants are not broken out by CDC, yet represent a significant share of recent GISAID sequences.

Replied in thread

**Kevin Karhan** @kkarhan@infosec.space · Mar 22

Mar 22

Kevin Karhan @kkarhan@infosec.space

Rant re: criminal neglect of politicans

**Eric's Risk Assessment** @EricCarroll@zeroes.ca · Mar 15 *

Mar 15 *

Eric's Risk Assessment @EricCarroll@zeroes.ca

Ensitrelvir Prevents #COVID19 Infection as Post Exposure Prophylaxis

> Japan-based Shionogi presented results for its investigational antiviral, ensitrelvir, that demonstrated a 67% reduction in the risk of developing COVID-19 in uninfected individuals treated after exposure, compared to a placebo at day 10

https://www.contagionlive.com/view/ensitrelvir-prevents-covid-19-infection-as-post-exposure-prophylaxis

ContagionLive · Mar 13Ensitrelvir Prevents COVID-19 Infection as Post Exposure ProphylaxisBy John Parkinson

#sars2 #sarscov2 #antiviral

Continued thread

**sport of sacred spherical cows** @beadsland@hcommons.social · Mar 14

Mar 14

sport of sacred spherical cows @beadsland@hcommons.social

Second time #CDC has reported estimates for more than two regions at a time since October.

To be clear, national data used for chart above are modeled on regional data collection.

LP.8.1 now estimated at majority in Great Lakes, nearing majority in NY/NJ and Mid-Atlantic.

XEC (incl. XEC.4) still around a quarter share in all three regions.

[For color key, see: https://covid.cdc.gov/covid-data-tracker/#variant-proportions]

❖ #ThisIsOurPolio #Covid #Covid19 #SARS2 #variants #CovidIsNotOver #CovidIsAirborne #WearAMask #BetterMasks

Map: Nowcast Estimates for 3/2/2025 - 3/15/2025 by HHS Region
Source: Centers for Disease Control

Map shows pie charts for three of ten regions, reflecting regional estimated proportions for specimens collected for the most recent biweekly reporting period.

Bold text over Canada portion of map reads: "Nowcast estimates are only available for HHS regions having at least 300 sequences in the two weeks ending 02/15/2025".

Dominant strains by tracked region:

NY/NJ: LP.8.1 (orange) 47%, XEC (clover) 22%, LF.7 (dirty blue) 5%, LB.1.3.1 (fountain blue) 5%.

Mid-Atlantic: LP.8.1 (orange) 42%, XEC (clover) 25%, MC.28.1 (flat blue) 8%, KP.3.1.1 (sea bluish cyan) 5%.

Great Lakes: LP.8.1 (orange) 60%, XEC (clover) 24%, KP.3.1.1 (sea bluish cyan) 4%.

Of ten regions, seven regions are blank.

ALT-text by beadsland at ko-fi.

Continued thread

**sport of sacred spherical cows** @beadsland@hcommons.social · Mar 14

Mar 14

sport of sacred spherical cows @beadsland@hcommons.social

A FLuQE wavelet opened September, cresting as KP.3.1.1 / MC wave into November. FDA's second-guess vaccine target, KP.2, dropped out in December. Updated #CDC estimates indicate we've been in a JN.1.11 soup pretty much since then.

No new variants broken out by CDC, as KP.1.1.3 / LP descendant LP.8.1 approaches majority.

No recent GISAID data—as Raj's dashboard hasn't updated in near a month.

❖ #ThisIsOurPolio #Covid #Covid19 #SARS2 #variants #CovidIsNotOver #CovidIsAirborne #dataviz #datavis

**datum (n=1)** @datum@zeroes.ca · Mar 8

Mar 8

datum (n=1) @datum@zeroes.ca

"57% decreased odds of 1 or more PCC symptoms and a 73% decreased odds of 2 or more PCC symptoms" - that's dramatically lower odds of a child suffering:

unable to remember
unable to focus
unable to exercise
headache
insomnia
lightheadedness, fainting
extreme fatigue
loss of vivacity, joie de vivre
personality changes
hospitalization and death

Protect your children.

Otherwise, if they survive, they will wonder why you didn't protect them, when it costs only the time to get vaccinated, and a few pennies a day N95s and HEPA filters.

Otherwise, you might find yourself mourning the potential you KNEW your child had, and desperately hoping for treatments.

Treatments may never come. Neurons don't come back. Developmental windows close.

Don't be the ghoul that condemns your children, don't strip their future because it's not cool to mask. It might not be cool to wear a bike helmet either. Concussions can't be undone, either. Don't usher your children willingly into suffering and disability.

DON'T FUCKING STACK THE ODDS AGAINST YOUR KIDS.

https://pmc.ncbi.nlm.nih.gov/articles/PMC11851240/

ht/ @augieray https://mastodon.social/@augieray/114128494000879104

PubMed Central (PMC)COVID-19 Vaccination and Odds of Post–COVID-19 Condition Symptoms in Children Aged 5 to 17 YearsDoes COVID-19 mRNA vaccination reduce the occurrence of post–COVID-19 condition (PCC) following SARS-CoV-2 infection in children aged 5 to 17 years? In this case-control study with 622 participants, vaccination was associated with a 57% decreased ...

#vaccines #vaccine #COVID19

**datum (n=1)** @datum@zeroes.ca · Mar 1 *

Mar 1 *

datum (n=1) @datum@zeroes.ca

Learn from history. HISTORY INCLUDES THE PAST FIVE YEARS.

Statistics Canada is not falsifying huge datasets. https://www150.statcan.gc.ca/n1/daily-quotidien/231208/dq231208a-eng.htm?HPA=1

The Tyee is not falsifying long form reporting. https://thetyee.ca/Analysis/2024/07/02/What-We-Can-Do-Long-COVID/

McMaster researchers are chasing health, not grants. https://healthsci.mcmaster.ca/long-covid-what-you-need-to-know-about-post-covid-19-condition/ (though "can last months" should read "can last months, years, or perhaps never end.")

www150.statcan.gc.caThe Daily — Experiences of Canadians with long-term symptoms following COVID-19As of June 2023, the majority of Canadians had been infected by the virus causing COVID-19. Most people recover from their symptoms and are able to carry on with their lives, however, for many others, symptoms persist for months, often impacting their ability to work and their quality of life overall.

#CovidIsNotOver #LongCOVID #SARS2

Continued thread

**sport of sacred spherical cows** @beadsland@hcommons.social · Feb 28

Feb 28

sport of sacred spherical cows @beadsland@hcommons.social

#CDC has long time now been piloting the craft of #PublicHealth sans navigational equipment.

To be clear, national data used for chart above are modeled on regional data collection.

Given little data we do have, LP.8.1 now estimated as nearing majority status in NY/NJ, with XEC (incl. XEC.4) still near a third share.

As for other regions?

[For color key, see: https://covid.cdc.gov/covid-data-tracker/#variant-proportions]

❖ #ThisIsOurPolio #Covid #Covid19 #SARS2 #variants #CovidIsNotOver #CovidIsAirborne #WearAMask #BetterMasks

Map: Nowcast Estimates for 2/16/2025 - 3/1/2025 by HHS Region
Source: Centers for Disease Control

Map shows pie charts for one of ten regions, reflecting regional estimated proportions for specimens collected for the most recent biweekly reporting period.

Bold text over Canada portion of map reads: "Nowcast estimates are only available for HHS regions having at least 300 sequences in the two weeks ending 02/01/2025".

Dominant strains by tracked region:

NY/NJ: LP.8.1 (orange) 44%, XEC (clover) 26%, KP.3.1.1 (sea bluish cyan) 6%, XEC.4 (mint green) 6%.

Of ten regions, nine regions are blank.

ALT-text by beadsland at ko-fi.

Continued thread

**sport of sacred spherical cows** @beadsland@hcommons.social · Feb 28

Feb 28

sport of sacred spherical cows @beadsland@hcommons.social

After January's FLiRT soup (JN.1 and JN.1.11 lineages vying for dominance), we've returned to JN.1.11 soup (FLiRT and FLuQE clusters competing), that began when FLuQE majority ended in November.

#CDC breaks out a new FLuQE variant, MC.28.1, even as being squeezed by LP.8.1 fam.

Raj updated global dashboard Sunday, incl. hundreds of U.S. samples early Feb. Still await updated U.S. dashboard.

❖ #ThisIsOurPolio #Covid #Covid19 #SARS2 #variants #CovidIsNotOver #CovidIsAirborne #dataviz #datavis

Replied in thread

**author_is_ShrikeTronx7** @ShrikeTron@mstdn.social · Feb 26 *

Feb 26 *

author_is_ShrikeTronx7 @ShrikeTron@mstdn.social

@cbarbermd It's sad we built all these anonymous BT contact tracing apps monitoring, and learnings back during #SARS2, and we can't leverage any of it.

https://blog.google/inside-google/company-announcements/apple-and-google-partner-covid-19-contact-tracing-technology/

Google · Apr 10, 2020Apple and Google partner on COVID-19 contact tracing technologyBy Keyword Team

Continued thread

**sport of sacred spherical cows** @beadsland@hcommons.social · Feb 19

Feb 19

sport of sacred spherical cows @beadsland@hcommons.social

Updated GISAID data for late January has FluQE31 KP.3.1.1 / MC and children down to just over a fifth of all sequences.

FLiRT KS.1.1 / FLuQE KP.3.3 hybrid XEC down near two fifths.

LP.8.1 and child LP.8.1.1 / NY together already another fifth.

Meanwhile, in remaining fifth:
• JN.1 FLiRT descendant LF.7 remains diverse despite pressure; and
• XEQ (recombinant of FLiRT KS.1.1.2 and KP.3) continues to stand out.

❖ #ThisIsOurPolio #Covid #Covid19 #SARS2 #variants #CovidIsNotOver #CovidIsAirborne

Chart: SARSCoV2 Variant Dashboard - USA | 30-DAY TRENDS
Source: NYITCOM Research Report (Raj Rajnarayanan)

Caption (in part): Circulating Variants in…following US States: All - Specimen Collected in…last 30 days | Updated on 2/16/2025 4:45:09 AM [GMT?] | Source (sequences): GISAID

Packed-bubble chart showing tallies of each identified variant for each state, for collection dates 1/19/2025 to 2/1/2025. Top subvariants: XEC (24.06%), LP.8.1 (11.11%), LP.8.1.1 (9.8%), MC.10.1 (5.34%), MC.1 (4.23%), XEC.2 (4.09%).

Raj has standardized bubbles to violet (BA.2.86.*), aqua green (XBB.1.16.*), forest green (XEC, a recombinant of two B.2.86 strains), and yellow (LP.8.*). although some newer Pango aliases may still be getting unique colors assigned by Tableau.

Bubbles largest and most prominent for: XEC (forest) for New York (59), Colorado (53), Minnesota (25), New Jersey, California, Illinois, Nebraska, Iowa, Pennsylvania, Virginia, Delaware, Rhode Island; LP.8.1 (yellow) for New York (43), California, Iowa, Colorado, Delaware; LP.8.1.1 (yellow) for New York (36), Illinois (33), Minnesota, California; XEC.8 (forest) for Nebraska (24); XEQ (aqua) for Colorado (23).

Many dozens of bubbles of varying sizes representing near a hundred variants across various states.

ALT-text by beadsland at ko-fi.

Chart: Variants by Pango-Designated Lineage: U.S. Jan 19 to Feb 1
Source: GISAID (via Raj Rajnarayanan's COVID-19 Variant Dashboard, updated Feb 16)

[ beadsland on Ko-fi ]

Pie chart of major lineages, with lesser lineages bundled together by common alphanumeric initial character. Call-outs for each pie slice list number of variants counted and provide a percentage of pie.

Percentage is in a dull grey font, to which a dark backing has been applied to aid legibility.

Color key of pie slices aligns to that of latest "Estimated Variant Proportions by Common Name" (earlier in this thread), namely:

• Browns: JN.1.11 + FLiRT
• Greens: JN.1.11 + FLuQE
• Reds: XEC
• Purple: JN.1 + FLiRT-KS
• Blues: JN.1 + FLiRT
• Greys: Other

Reading clockwise from top:
- Multiple unlabeled slivers of grey and tan brown.
4.0% - KP.3.1.1 / MC [green]
- Unlabeled slice green.
1.9% - LB.1.3.1 (1 variant) [green]
- Unlbl. sliver of grey.
4.8% - LF.7 (8 variants) [blue]
9.8% - LP.8.1.1 (1 variant) [brown]
11.7% - LP.8.1 (2 variants) [brown]
- Unlbl. sliver tan.
5.7% - MC.1 (4 variants) [green]
Unlbl. sliver green.
5.3% - MC.10.1 (1 variant) [green]
- Two unlbl. slices green.
4.3% - other MC (17 variants) [green]
- Unlbl. slice grey.
2.3% - NL (4 variants) [blue]
1.2% - NC, NF, NB, NA, … [grey]
6.1% - XEC.2 (4 variants) [red]
1.8% - XEC.4 (1 variant) [pink red]
3.1% - XEC.8 (1 variant) [red]
28.9% - other XEC (12 variants) [red]
- Unlbl. slice tan.
2.4% - XEQ (1 variant) [grey]
- Unlbl. sliver grey.

Continued thread

**sport of sacred spherical cows** @beadsland@hcommons.social · Feb 19 *

Feb 19 *

sport of sacred spherical cows @beadsland@hcommons.social

#CDC has long time now been piloting the craft of #PublicHealth sans navigational equipment.

To be clear, national data used for chart above are modeled on regional data collection.

Given little data we do have, LP.8.1 has gained plurality status in NY/NJ and Great Lakes regions, XEC still majority in Mtn/Dakotas, with cousin XEQ prominent.

[For color key, see: https://covid.cdc.gov/covid-data-tracker/#variant-proportions]

❖ #ThisIsOurPolio #Covid #Covid19 #SARS2 #variants #CovidIsNotOver #CovidIsAirborne #WearAMask #BetterMasks

Map: Nowcast Estimates for 2/2/2025 - 2/15/2025 by HHS Region
Source: Centers for Disease Control

Map shows pie charts for three of ten regions, reflecting regional estimated proportions for specimens collected for the most recent biweekly reporting period.

Bold text over Canada portion of map reads: "Nowcast estimates are only available for HHS regions having at least 300 sequences in the two weeks ending 01/18/2025".

Dominant strains by tracked region:

NY/NJ: LP.8.1 (orange) 34%, XEC (clover) 33%, KP.3.1.1 (sea bluish cyan) 9%, XEC.4 (mint green) 7%.

Great Lakes: LP.8.1 (orange) 38%, XEC (clover) 37%, KP.3.1.1 (sea) 6%.

Mtn/Dakotas: XEC (clover) 44%, LP.8.1 (orange) 16%, XEQ (slate blue) 14%, MC.10.1 (sapphire blue) 7%, KP.3.1.1 (sea) 6%.

Of ten regions, seven regions are blank.

ALT-text by beadsland at ko-fi.

Continued thread

**sport of sacred spherical cows** @beadsland@hcommons.social · Feb 19 *

Feb 19 *

sport of sacred spherical cows @beadsland@hcommons.social

After January's FLiRT soup (JN.1 and JN.1.11 lineages vying for dominance), we've returned to JN.1.11 soup (FLiRT and FLuQE clusters competing), that began when FLuQE majority ended in November.

After no data two weeks ago, #CDC updated variant estimates.

Raj has updated dashboard Sunday with new GISAID sequences. As of data two weeks ago, XEC.8 joins XEC.2 and LP.8.1.1 / NY as significant.

❖ #ThisIsOurPolio #Covid #Covid19 #SARS2 #variants #CovidIsNotOver #CovidIsAirborne #dataviz #datavis

Continued thread

**sport of sacred spherical cows** @beadsland@hcommons.social · Feb 14 *

Feb 14 *

sport of sacred spherical cows @beadsland@hcommons.social

After no data two weeks ago, #CDC updates variant estimates.

After January's FLiRT soup (JN.1 and JN.1.11 lineages vying for dominance), we've returned to JN.1.11 soup (FLiRT and FLuQE clusters competing), that began when FLuQE majority ended in November.

There's been insufficient GISAID data for Raj to update U.S. dashboard. Might assume LP.8.1.1 / NY continues to drive growth of LP.8.1 fam.

❖ #ThisIsOurPolio #Covid #Covid19 #SARS2 #variants #CovidIsNotOver #CovidIsAirborne #dataviz #datavis

Replied in thread

**author_is_ShrikeTronx7** @ShrikeTron@mstdn.social · Feb 13

Feb 13

author_is_ShrikeTronx7 @ShrikeTron@mstdn.social

We saw similar with increased business and lower air-pollution when we shut down cars during #SARS2.

Maybe we should do that again.

Replied in thread

**author_is_ShrikeTronx7** @ShrikeTron@mstdn.social · Feb 9 *

Feb 9 *

author_is_ShrikeTronx7 @ShrikeTron@mstdn.social

@Lorrrraaaaine @GeorgiaOnMyMind @melanie Constant reminder that we've learned nothing with #SARS2 and slowing down Smoking.

Our lungs are a precious base for life, infections are a **choice**, and claiming there's no after-effects is denial.

The "Survivor's Bias" in the recent new outbreaks is inexcusable, but also necessary lessons.

**Samara** @samara@climatejustice.social · Feb 5

Feb 5

Samara @samara@climatejustice.social

What the media doesn’t tell you about your risk in this #measles outbreak:
1- A well sealed respirator { #N95 } is needed to keep from breathing in this virus
2- If you’ve had covid, your immune system is damaged. Now any kind of infection is likely to be more severe.
3- Measles is #airborne. So is #influenza, #norovirus, #SARS2, #RSV, #tuberculosis, #monkeypox . Virus can spread in a vacant room hours after the infected person leaves. See #1 - wear an N95 / FFP2.
4- Good hygiene is always a good idea. This includes air hygiene.

#Samara #SamaraVirus #SamaraSARS
https://www.ctvnews.ca/toronto/local/york/article/officials-warn-of-possible-measles-exposure-at-2-locations-in-newmarket/

CTVNews · Feb 5Officials warn of possible measles exposure at 2 locations in NewmarketYork Region Public Health is warning the public about a possible exposure to a confirmed case of measles in Newmarket last week.

Replied in thread

**author_is_ShrikeTronx7** @ShrikeTron@mstdn.social · Feb 5

Feb 5

author_is_ShrikeTronx7 @ShrikeTron@mstdn.social

@NataliaArmyOf1 Meanwhile their eternal messaging fight between:
* #SARS2 is the flu
* #SARS2 is a bioweapon, but do nothing about that except shut down the CDC
* deaths are hoaxes
* it killed a lot of people, but don't mask or vaccinate

**author_is_ShrikeTronx7** @ShrikeTron@mstdn.social · Feb 2

Feb 2

author_is_ShrikeTronx7 @ShrikeTron@mstdn.social

@jnl Until the USA **really** feels it, they will deny it's happening (like #SARS2 where __only__ 1.2+ million died).

So since USA tends to be in heavy drugged denial all the time, hit them as hard as you can, so it scars, so they will remember not to be so stupid again.

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