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#restriction

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FreeSchool = W🔁rk T🔁gether☑

@freemo @messaroundmarx There are 2 quotes here.
I assume it's the 2nd quote mostly about authoritarianism that is mostly the focus...

...which, if so, would you consider authority or authoritarianism as an uncaring (or almost financially-only caring) Bank and State Authority as the kind of dictator(s) or de-facto equivalent (i.e. without you totally using Bank or State then you are a mere nothing deliberately made increasingly conditional, whether they declare themselves as this or that political label.

Those two (or just for the purposes of this reply) are sole rulers and sources of life (or monopoly of it) and soon imprisoning people for non-conforming reasons (more examples of kangeroo #courts / #juries asked to #ignore evidence / terrorism chargers used on Twitter / Mastodon style social people silences and in jail / mothers arrested fpr speaking etc)...

So theoretically or de-facto would you agree Modern #Capitalism (or just today's type of actions and non-action of Banks 🏦 and State 👮 (whatever we call their actions as) is requiring these two authorities and not just the softer or neutral types of Capitalism.

The increasing #ultimatum and #conditional demanding #conforming to (or take it or leave life if you want) makes increasingly everything #illegal or incompatible by default and today's kind of Capitalism is more #punishment orientated...

Capitalism here as a constantly changing or added #restriction / #redefinition which is why we can not just focus on #labels like Authoritarianism but the #behaviour and track #record / #history, as well as what they #finance (#war), how they have things failed constantly in echange for profit / power etc etc, that contribute to similar things...

As part of constant systematic pattern (whatever we call that) and even considering people being #ignorant also (yes), but definitely no change to that model of #business as usual. Namely #tax, #territorial #aggression etc.

And on the other side more positive to humans, today it's hardly about #communication between #state and people, giving power to people, talking about well-being of humans, which I'd include as part of what makes it "Authoritarian style" behaviour also when it's without those components and considerations... would you agree?

Happy New Year by the way :)

Public
Giuseppe Michieli

#Replication #Restriction of #Influenza #H5N1 Clade 2.3.4.4b Viruses by #Human Immune Factor, 2023–24, Emerg Infect Dis.: wwwnc.cdc.gov/eid/article/31/1

We show that human myxovirus resistance protein 1 (MxA) suppresses replication of influenza H5N1 viruses isolated from #mammals in vitro and in MxA-transgenic mice. However, H5N1 can evade MxA restriction through replacement of individual viral #polymerase complex components from a human-adapted MxA-resistant strain in vitro.

Emerging Infectious Diseases journalReplication Restriction of Influenza A(H5N1) Clade 2.3.4.4b Viruses by Human Immune Factor, 2023–2024HPAI A(H5N1) Clade 2.3.4.4b Viruses, 2023–2024
Public
Giuseppe Michieli

An emerging #PB2-627 #polymorphism increases the #pandemic #potential of avian #influenza virus by breaking through ANP32 #host #restriction in #mammalian and avian hosts, BioRxIV: biorxiv.org/content/10.1101/20

...we discovered a new independent #cluster with PB2-627V emerged in the 2010s, which is prevalent in various avian, mammalian, and human isolates of AIVs, including #H9N2, #H7N9, #H3N8, 2.3.4.4b #H5N1, and other subtypes.

bioRxiv · An emerging PB2-627 polymorphism increases the pandemic potential of avian influenza virus by breaking through ANP32 host restriction in mammalian and avian hostsAlterations in the PB2-627 domain could substantially increase the risk of an avian influenza virus (AIV) pandemic. So far, a well-known mammalian mutation PB2-E627K has not been maintained in AIV in poultry, which limits the spread of AIVs from avian to humans. Here, we discovered a variant, PB2-627V, which combines the properties of avian-like PB2-627E and human-like PB2-627K, overcoming host restrictions and posing a risk for human pandemics. Specifically, by screening the global PB2 sequences, we discovered a new independent cluster with PB2-627V emerged in the 2010s, which is prevalent in various avian, mammalian, and human isolates of AIVs, including H9N2, H7N9, H3N8, 2.3.4.4b H5N1, and other subtypes. And, the increasing prevalence of PB2-627V in poultry is accompanied by a rise in human infection cases with this variant. Then we systematically assessed its host adaptation, fitness, and transmissibility across three subtypes of AIVs (H9N2, H7N9, and H3N8) in different host models, including avian and human cells, chickens, mice, and ferrets where infections naturally occur. We found that PB2-627V facilitates AIVs to efficiently replicate and infect chickens and mice by utilizing both avian- and human-origin ANP32A proteins. Importantly, and like PB2-627K, PB2-627V promotes efficient transmission between ferrets through respiratory droplets. Deep sequencing in passaged chicken samples and transmitted ferret samples indicates PB2-627V maintains stable functionality across the two distinct hosts. Therefore, the mutation has the ability to continue spreading among poultry and can also overcome the barrier between birds and humans, greatly enhancing the likelihood of AIVs infecting humans. Given the escalating global spread of AIVs, it is crucial to closely monitor influenza viruses carrying PB2-627V to prevent a pandemic. ### Competing Interest Statement The authors have declared no competing interest.
Public
Alaska Native News

Use off-highway vehicles delayed while trails dry out in the White Mountains National Recreation Area
[the_ad id="30587"]

Motor vehicles restricted from trails May 1 – May 24

White Mountains National Recreation Area trails with motorized use restriction May 1 - May 24.

FAIRBANKS, Alaska —The...
alaska-native-news.com/use-off
#whitemountains #alaska #recreational #motorized #restriction

Public
Giuseppe Michieli

#Mutations accumulated in the #Spike of #SARS-CoV-2 #Omicron allow for more efficient counteraction of the #restriction factor BST2/ #Tetherin journals.plos.org/plospathogen

journals.plos.orgMutations accumulated in the Spike of SARS-CoV-2 Omicron allow for more efficient counteraction of the restriction factor BST2/TetherinAuthor summary BST2/Tetherin is a potent antiviral factor that prevents the egress of multiple enveloped viruses. In turn, viruses have evolved mechanisms to circumvent this block. Here, we found that SARS-CoV-2 primarily uses the Spike protein to promote the lysosomal degradation of BST2, thus, removing it from sites of virion assembly and facilitating virus release. When analyzing several SARS-CoV-2 variants of concern, we found that Omicron is more efficient at counteracting BST2, to the point where its replication is barely impacted by this restriction factor. Subsequent studies identified mutations accumulated in the Omicron Spike as responsible for improving an interaction between Spike and BST2. However, the surfaces in BST2 required for this association differ between Wuhan and Omicron. Remarkably, increased Spike-BST2 binding is associated with enhanced BST2 downregulation. Therefore, these observations suggest that, in addition to enhancing receptor binding and immune evasion, mutations in the Spike afford more efficient counteraction of BST2, highlighting that BST2 antagonism is important for SARS-CoV-2 infectivity.
Public
Malaysia Public Transport

#Bus operators in #Kuching have raised their concerns over the recent mileage #restriction to only 40km and below for the RM1 #busfare #subsidy programme.

The new #policy would affect the #rural dwellers and those from the #lowincome group (#B40) the most.

Many bus operators had to cease businesses due to the tough operating environment.

Read more: theborneopost.com/2024/01/03/b

A bus station master standing in front of buses at a station. / Photo from linked article.
#Sarawak#buses#beese
Continued thread
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Susan Larson ♀️🏳️‍🌈🏳️‍⚧️🌈

#US. #District #Judge #ThomasParker, a #Trump #appointee, #ruled the #dragban “is an #unconstitutional #restriction on #speech.”

The District Attorney wrote in a three-page “#notice” addressed to #BlountPride organizers and distributed to local #law #enforcement, “however if sufficient #evidence is presented to this office that the #unconstitutional #criminal #statutes have been #violated, our office will ethically and justly prosecute these cases in the interest of justice.”

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