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#ovarian

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Howard Smith MD, AM

Improving Ovarian Cancer Immunotherapy: Cancer immunologists at the University of Virginia have now discovered what underlies this failure. #immunotherapy #checkpointinhibitor #ovarian #cancer #biome #flagellin
instagram.com/reel/DHDygk-shuL

InstagramHoward G. Smith MD, AM on Instagram: "Improving Ovarian Cancer Immunotherapy Immunotherapy has been a resounding success for melanoma skin cancer and small cell lung cancer. Not so for ovarian cancer. Cancer immunologists at the University of Virginia have now discovered what underlies this failure. Their research discovered that flagellin protein from gut bacteria blocks the effectiveness of the checkpoint inhibitors that power most current immunotherapy. This bacterial flagellin inhibits immune cell communication helping tumors flourish rather than die. Using a mouse model and blocking flagellin action restored immunotherapeutic effectiveness with 80% of treated animals enjoying long-term tumor control. If this approach is effective for human ovarian cancer patients, coupling flagellin blocking with checkpoint immunotherapy may be a winning therapeutic strategy …..someday soon. https://newsroom.uvahealth.com/2025/02/11/ovarian-cancer-discovery-could-turn-ailed-treatment-into-lifesaver/ https://aacrjournals.org/cancerimmunolres/article-abstract/doi/10.1158/2326-6066.CIR-24-0513/751676/TLR5-signaling-causes-dendritic-cell-dysfunction?redirectedFrom=fulltext #immunotherapy #checkpointinhibitor #ovarian #cancer #biome #flagellin"3 likes, 0 comments - drhowardsmithreports on March 11, 2025: "Improving Ovarian Cancer Immunotherapy Immunotherapy has been a resounding success for melanoma skin cancer and small cell lung cancer. Not so for ovarian cancer. Cancer immunologists at the University of Virginia have now discovered what underlies this failure. Their research discovered that flagellin protein from gut bacteria blocks the effectiveness of the checkpoint inhibitors that power most current immunotherapy. This bacterial flagellin inhibits immune cell communication helping tumors flourish rather than die. Using a mouse model and blocking flagellin action restored immunotherapeutic effectiveness with 80% of treated animals enjoying long-term tumor control. If this approach is effective for human ovarian cancer patients, coupling flagellin blocking with checkpoint immunotherapy may be a winning therapeutic strategy …..someday soon. https://newsroom.uvahealth.com/2025/02/11/ovarian-cancer-discovery-could-turn-ailed-treatment-into-lifesaver/ https://aacrjournals.org/cancerimmunolres/article-abstract/doi/10.1158/2326-6066.CIR-24-0513/751676/TLR5-signaling-causes-dendritic-cell-dysfunction?redirectedFrom=fulltext #immunotherapy #checkpointinhibitor #ovarian #cancer #biome #flagellin".
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Auscandoc

It checks the 12 most common forms of the disease: , , , , , , , , , , and soft tissue , and .

Scientists at Southampton University are understood to have used clinical information from 20,000 cancer patients to develop the screening.

The next stage involves improving the efficacy of the artificial intelligence involved, which analyses the test samples and biomarkers”

(2/2)

Public
Scientific Frontline

Treatment with the #nanoparticle reduced #ovarian #tumor growth by more than 50% in human cells and animal models. Women diagnosed with ovarian #cancer may initially respond well to #chemotherapy, but the majority of them will develop resistance to treatment and die from the disease.
#Medical #sflorg
sflorg.com/2024/02/med02222402

www.sflorg.comOutsmarting chemo-resistant ovarian cancerNew approach with nanoparticle starves cells of cholesterol and reduces tumor growth by 50%
Public
Carolyn Barber, MD

What a beautiful gift. Casey McIntyre died of but the fundraiser she started has raised nearly $220K. This should pay off ~$20M of others . 👏👏👏

$1 donated abolishes about $100 of medical debt

“To see that Casey’s good and happy life is continuing in this way is very beautiful to me,” her husband said.

Her fundraiser: tinyurl.com/5rks9c2z
NYT piece: tinyurl.com/mr2vtem7

RIP Medical DebtNationwide - RIP Medical DebtCasey Ryan McIntyre, 38, beloved mother, wife, sister, daughter, niece, and aunt died on November 12th, 2023. As Publisher at Razorbill, an imprint of Penguin Random House, she derived great joy from publishing books for a new generation of readers, and saw herself in every child sprawled out on a couch, rug, or bunk bed engrossed in their latest book obsession. She was an consummate New Yorker who always knew which bodegas had the best magazine selections, whether to take the B or the Q, what restaurants were best to spot celebrities, and gave every […]
Public
Matt Willemsen

The $3 Lifesaver: New Blood Test Could Detect Common Deadly Cancers Sooner
Researchers have developed a cost-effective, multi-cancer blood test that can detect a protein, LINE-1-ORF1p, produced by cancer cells, potentially leading to early detection. This protein is elevated in many cancers and the test’s ability to spot it early can save lives.
scitechdaily.com/the-3-lifesav #BloodTest #cancer #biomarkers #diagnostic #protein #carcinoma #ovarian #gastroesophageal #colorectal

SciTechDaily · The $3 Lifesaver: New Blood Test Could Detect Common Deadly Cancers SoonerMost cancers become deadly by maintaining a low profile, only showing symptoms when they're too advanced to treat. Ovarian and gastroesophageal cancers are among the most notorious for this sly disease progression, often leading to late-stage diagnoses. Now an international team of researchers, i
Public
Auscandoc

Phase 1 clinical trial underway to test City of Hope-developed cancer treatment news-medical.net/news/20230801

“Results have been promising. can suppress tumor growth as a monotherapy or combination treatment in cell and animal models without resulting in toxicity.

AOH1996 has been effective in preclinical research treating cells derived from , , , , , and ”

News-Medical.netPhase 1 clinical trial underway to test City of Hope-developed cancer treatmentResearchers at City of Hope, one of the largest cancer research and treatment organizations in the United States, today published a new study explaining how they took a protein once thought to be too challenging for targeted therapy, proliferating cell nuclear antigen (PCNA), and developed a targeted chemotherapy that appears to annihilate all solid tumors in preclinical research.
Public
Glasnozt

Set up in my calendar is a reminder that on this day, now 9 years ago, I was diagnosed with Stage 3 #Ovarian #cancer Two things about this. I've survived and apparently, I'm a miracle (the odds of survive for ovarian cancer are dire). The other is that it was my husband who set this reminder up in my calendar. Not long after I'd had my diagnosis and was undergoing treatment, he was diagnosed with Oesophageal cancer. 8 years ago, he died. So... yay, I lived to tell tale, but...

Public
Bruce Kendall

Cannabis and ovarian cancer: continuing Michelle Kendall’s legacy

This new article on Cannabis Health News tells the story of my dear Michelle's struggle to overcome #OvarianCancer using #MedicalCannabis and the research that we launched to study how #Cannabis might be a treatment for this terrible disease.

The article summarizes our recently published study showing how cannabis can kill #ovarian #cancer cells in a lab context.

cannabishealthnews.co.uk/2023/

#CannabisIsMedicine
#CancerWarrior

Cannabis Health NewsCannabis and ovarian cancer: continuing Michelle Kendall’s legacyBruce Kendall and Professor Hinanit Koltai share the remarkable story behind a promising new study.
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