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#Neurotransmitter

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"We characterized the interaction of SNAP-25-derived peptides with Hsc70 and CSPα using a combination of biochemical and biophysical techniques, including native-PAGE, binding affinity by fluorescence anisotropy, ATPase-activity of Hsc70, and NMR. We have identified an Hsc70 binding site within SNAP-25 that is likely to represent the site used in the cell to facilitate SNARE complex formation."

jbc.org/article/S0021-9258(24)

wanna know why western democracies consider sleep deprivation to be a form of physical and psychological torture?

after a certain point even the strongest of minds will capitulate, they will fold, and they will admit to whatever is demanded just to be able to rest. they may have no recollection, no memory, nor cognitive capacity to comprehend the passage of time... the brain eventually shuts down non-critical functions, leaving only the autonomic nervous system to maintain its most basic functions.

they'll give you five minutes that feels like an hour, six that feels like a month, but never truly rest, prodded back to the conscious realm to simply say, "yes... yes, yes... just leave me be..."

what may remain of those scattered memories? just rest your head little one, and you may see, in the mind's eyes, that nothing ever changed... "WAKE UP! five minutes!"

New paper from our lab linking #computational #models to chemoarchitecture in the #human #brain.

Chemoarchitecture, i.e. the spatial distribution of #neurotransmitter receptor densities, plays a vital role in human brain function. In sensory cortices, receptive fields also play a vital role in human brain function. We recently introduced a computational model of (population) receptive fields that incorporates divisive normalization to explain a variety of seemingly distinct responses through local variations in model parameters (pnas.org/doi/10.1073/pnas.2108).

Here, we link chemoarchitecture to computational models of population receptive fields and divisive normalization. Specifically, we report a striking alignment between variations in computational model parameters and the spatial distribution of neurotransmitter receptor densities, in particular GABA and serotonin receptors. We show that chemoarchitecture provides a plausible biological implementation for modulations of information processing in the human brain.

With Marco Aqil and @tknapen

science.org/doi/full/10.1126/s

Central Nervous System: Is creatine a CNS neurotransmitter?
A range of experiments suggests that creatine, a molecule known for recycling ATP in muscle and brain tissue, may also function as a neurotransmitter in the central nervous system.
elifesciences.org/articles/918 #CNS #creatine #neurotransmitter

eLifeCentral Nervous System: Is creatine a CNS neurotransmitter?A range of experiments suggests that creatine, a molecule known for recycling ATP in muscle and brain tissue, may also function as a neurotransmitter in the central nervous system.

What happens in the #tango is between the two people and no-one else. The couple dance to please each other not t crowd.
When they dance for t crowd, that is called 'showing off', or 'show-dancing', like u see on TV in UK Strictly.
#argentinetango is a subtle, intellectual dance which begins with the monumental #cabeceo.

Ivica Anteski writes about it here>> tangomentor.com/why-cabeceo-mi

Tango MentorWhy do we need cabeceo/mirada? | There's a better wayThe five reasons why should you respect the cabeceo/mirada rule and how can they help you to have smoother experience in milognas no matter where you are.