#Cellular structure without a #membrane: Researcher discusses how #synapses use #liquids to create functional separations.

#LLPS #membrane-less_organelles #neurotransmission

https://phys.org/news/2025-03-cellular-membrane-discusses-synapses-liquids.html

Marveling the Mysteries of Memory: How Our Brain Reactivates and Perceives Sensory Experiences

#MemoryMagic #SensoryPerception #Neuroscience #Hippocampus #CognitiveFunction #Neuroplasticity #OlfactorySenses #PTSD #EmotionalHealth #BrainScience #CognitiveDysfunction #MindAndBody #Neurotransmission #MemoryReactivation #MentalHealthMatters

https://youtube.com/shorts/1BQGQkJ1LwY?feature=share

"We characterized the interaction of SNAP-25-derived peptides with Hsc70 and CSPα using a combination of biochemical and biophysical techniques, including native-PAGE, binding affinity by fluorescence anisotropy, ATPase-activity of Hsc70, and NMR. We have identified an Hsc70 binding site within SNAP-25 that is likely to represent the site used in the cell to facilitate SNARE complex formation."

https://www.jbc.org/article/S0021-9258(24)02503-1/fulltext

"Knock out of Noelins1-3 profoundly reduced AMPARs in synapses onto excitatory and inhibitory (inter)neurons, decreased their density and clustering in #dendrites, and abolished activity-dependent #synaptic plasticity. Our results uncover an endogenous mechanism for #extracellular anchoring of AMPARs and establish Noelin-organized networks as versatile determinants of constitutive and context-dependent #neurotransmission."

https://www.cell.com/neuron/fulltext/S0896-6273(23)00546-9?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0896627323005469%3Fshowall%3Dtrue

Screen in #Celegans yields potential targets to delay motor #aging, including the PI3K VPS-34. VPS-34 inhibition improves #neurotransmission & muscle integrity via increased PI(3)P-PI-PI(4)P conversion, improving #MotorAging in worms & mice #PLOSBiology https://plos.io/3XNjhHn

Is #neurotransmission to #consciousness as water is to a stream? Without the water, no stream. Yet to identify a particular spot along a stream, we do so not in terms of particular physical water molecules but rather in terms of "extra-stream" landmarks. Similarly, it is in terms of relatively fixed, not flowing, elements that we "navigate" consciousness. Such entities may be, eg, synaptically weighted habits; not particles of the stream's water, but features giving rise to riffles, pools, runs.

Cortical thinning is associated with altered neurotransmission in young adults with a history of heavy drinking since adolescence

The article discusses a recent study conducted in Finland that explored the effects of #heavy #alcohol #consumption during #adolescence on #brain #development.

The study followed a group of young adults over a 10-year period, comparing those with a history of heavy drinking in adolescence to those who consumed little or no alcohol. The researchers found that the heavy-drinking group had #lower #cortical #gray #matter #thickness in several brain regions and #altered #neurotransmission compared to the control group.

Specifically, they observed increased activity in inhibitory neurotransmitters and thinner gray matter in the #frontal and #parietal lobes.

The study highlights the potential negative impact of heavy alcohol use during adolescence on brain structure and function, emphasizing the need for further research to understand the underlying mechanisms

| University of Eastern Finland

https://www.uef.fi/en/article/cortical-thinning-is-associated-with-altered-neurotransmission-in-young-adults-with-a-history-of

Been wondering for many years: there must be undiscovered receptors in the brain? For me, #fresh #orange #juice consistently clears #brain #fog in seconds, and more strongly so than #coffee; no such effect after fermentation; #neuroscience #neurotransmission #neurotransmitter

Structures of my old friend kainate receptor GluK2 with the no-longer AMPA-receptor specific anti-epileptic drug Perampanel bound, and a blocker of desensitisation. Sobolevsky lab.

https://www.cell.com/cell-reports/fulltext/S2211-1247(23)00135-3

The RNA-binding protein #FMRP binds the Csw/SHP2 transcript, in turn regulating presynaptic MAPK/ERK signaling & #neurotransmission. This mechanistically links two cognitive disorders; #NoonanSyndrome & #FragileX syndrome #PLOSBiology https://plos.io/3JjpqG0

The RNA-binding protein #FMRP binds the Csw/SHP2 transcript, in turn regulating presynaptic MAPK/ERK signaling & #neurotransmission. This mechanistically links two cognitive disorders; #NoonanSyndrome & #FragileX syndrome #PLOSBiology https://plos.io/3JjpqG0

The RNA-binding protein #FMRP binds the Csw/SHP2 transcript, in turn regulating presynaptic MAPK/ERK signaling & #neurotransmission. This mechanistically links two cognitive disorders; #NoonanSyndrome & #FragileX syndrome #PLOSBiology https://plos.io/3JjpqG0