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#neurosalience

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Outstanding wisdom-packed #NeuroSalience interview of Mesulam, for instance:
"...(different) methods give you different visions about how the brain is put together."
--Marsel Mesulam

podcasters.spotify.com/pod/sho

Spotify for PodcastersNeurosalience #S4E9 with Marsel Mesulam - 50+ years of brain research and importance of bubbles by OHBM NeurosalienceIt is our great pleasure and deep honor to host Dr. Marsel Mesulam who is a giant in the field of Neurology and one of founders of OHBM. Dr. Mesulam is Chief of Behavioral Neurology and the Ruth Dunbar Davee Professor of Neuroscience at Northwestern University Feinberg School of Medicine, and Professor of Behavioral Neurology at the Weinberg College of Arts and Sciences.Dr. Mesulam received his MD from Harvard Medical School in 1972, and in 1976 completed residencies at Boston City Hospital and Beth Israel Deaconess Medical Center in Boston. After a 1 year postdoc at Harvard University he began his tenure in Chicago at Northwestern. Dr. Mesulam's work has been both prodigious and impactful over the years, as his almost 1000 papers have been cited over 140 thousand times. He has written the seminal book, Principles of Behavioral and Cognitive Neurology, and has produced many landmark papers - a few of which we'll discuss in the podcast. One paper that we consider a masterpiece was published in Brain in 1998 and titled From Sensation to Cognition. This can be considered as a required reading for everyone in the field of brain mapping as it lays out so concisely and eloquently, a breathtaking perspective of the structure and functional organization of the human brain. Dr. Mesulam's research is extremely broad and diverse, having impacted such areas as neural networks and functional imaging, Dementia, Alzheimer's Disease, Primary Progressive Aphasia (PPA), Cholinergic Pathways, Acetylcholinesterase Studies, Cognitive Psychology, Neurology, and Neuropsychiatry. He also developed, early in his career, a neuronal marker, Tetramethyl benzidine, that profoundly impacted research in this area. In this inspiring conversation, Peter and Marsel discuss his early career and what was important for his success, delve into research culture and the value of opportunistic research, and the value of having the freedom and resources to try many things and rapidly change directions that follow interesting leads. They also discuss some of the exciting early days of Neuroimaging and OHBM. Lastly, we go into some of his current research on Primary Progressive Aphasia (PPA) and the study of temporal pole disease as a window to temporal pole functional significance. We hope that you enjoy this conversation. Episode producers:Alfie WearnOmer Faruk Gulban
Spotify for PodcastersS04E03: Paradigm shifts and big picture challenges in fMRI with Russ Poldrack by OHBM NeurosalienceIn this episode our guest is Dr. Russ Poldrack who has been so influential to the fields of fMRI, cognitive neuroscience, and brain imaging in general for the past 30+ years. Russ is the Albert Ray Lang Professor of Psychology at Stanford University and Director of the Center for Open and Reproducible Science. Over the years, he has helped elevate how we do fMRI by creating resources and standards for sharing data and code. He is also working to advance the precision with which we think about task design and data interpretation through his Cognitive Atlas project, which is a knowledge base for cognitive neuroscience.   Russ Poldrack received his Bachelors in Psychology from Baylor University in 1989, and his Ph.D. from the University of Illinois, Urbana/Champaign in 1995. After a postdoc at Stanford, he started, in 1999, as an assistant professor at Harvard University and Mass General Hospital, in 2002 he moved to UCLA, then in 2009, he became the director of the imaging research center at the University of Texas at Austin. Finally, in 2014 he was recruited to Stanford, where he has been ever since.  In this discussion, Peter and Russ look back into some of the paradigm shifts in fMRI best practices that Russ helped foster, as well as some of the big picture challenges that we face when using brain imaging, modeling, and precision task design to derive new insights into brain organization and mechanisms of computation. Here, Russ also weighs in on the prospects of fMRI for biomarker derivation and the exciting potential for single subject deep imaging.  Peter mentioned to Russ that this was one of the fastest hours he has experienced in quite some time as it was an engrossing discussion. Enjoy listening!  Episode producers Jeff Mentch Omer Faruk Gulban Brain Art Artist: Mia Coutinho Title: Represent, Connect, Empower