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Giuseppe Michieli<p>Variable <a href="https://mstdn.science/tags/DPP4" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>DPP4</span></a> <a href="https://mstdn.science/tags/expression" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>expression</span></a> in multiciliated cells of the <a href="https://mstdn.science/tags/human" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>human</span></a> <a href="https://mstdn.science/tags/nasal" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>nasal</span></a> <a href="https://mstdn.science/tags/epithelium" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>epithelium</span></a> as a determinant for <a href="https://mstdn.science/tags/MERS" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>MERS</span></a>-CoV tropism, <a href="https://etidiohnew.blogspot.com/2025/03/variable-dpp4-expression-in.html" rel="nofollow noopener noreferrer" translate="no" target="_blank"><span class="invisible">https://</span><span class="ellipsis">etidiohnew.blogspot.com/2025/0</span><span class="invisible">3/variable-dpp4-expression-in.html</span></a></p>
Doktor Overcomma :vepi:<p>Nose-shaping technology was at its height in the 1920s. But nasal Lamarckism kicked in, infants began to be born with acceptable noses, and within two generations nasal correction technology was first side-lined and then forgotten. We don't even have back-alley nose-modification clinics nowadays.<br><a href="https://dobbs.town/tags/Lamarckism" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Lamarckism</span></a> <a href="https://dobbs.town/tags/nose" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>nose</span></a> <a href="https://dobbs.town/tags/nasal" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>nasal</span></a></p>
I've got questions<p>Has anyone here had Deviated Septum Surgery? What was your experience like? Did you regret it at any point?</p><p>I'm scheduled to go under the knife tomorrow. I should have probably asked this months ago.</p><p><a href="https://hear-me.social/tags/surgery" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>surgery</span></a> <a href="https://hear-me.social/tags/deviatedseptum" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>deviatedseptum</span></a> <a href="https://hear-me.social/tags/nose" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>nose</span></a> <a href="https://hear-me.social/tags/ent" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>ent</span></a> <a href="https://hear-me.social/tags/earnosethroat" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>earnosethroat</span></a> <a href="https://hear-me.social/tags/nasal" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>nasal</span></a> <a href="https://hear-me.social/tags/septum" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>septum</span></a> <a href="https://hear-me.social/tags/snoring" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>snoring</span></a> <a href="https://hear-me.social/tags/cpap" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>cpap</span></a> <a href="https://hear-me.social/tags/sleep" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>sleep</span></a> <a href="https://hear-me.social/tags/sleepapnea" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>sleepapnea</span></a></p>
Steven Saus [he/him]<p>From 19 Sep: Homeopathic company refuses to recall life-threatening nasal spray, FDA says - EnlargeGetty Florian Gaertner The maker of a homeopathic nasal spray with a h... <a href="https://arstechnica.com/science/2024/09/fda-warns-of-life-threatening-infections-from-contaminated-nasal-spray/" rel="nofollow noopener noreferrer" translate="no" target="_blank"><span class="invisible">https://</span><span class="ellipsis">arstechnica.com/science/2024/0</span><span class="invisible">9/fda-warns-of-life-threatening-infections-from-contaminated-nasal-spray/</span></a> <a href="https://faithcollapsing.com/tags/fda" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>fda</span></a> <a href="https://faithcollapsing.com/tags/homeopathy" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>homeopathy</span></a> <a href="https://faithcollapsing.com/tags/nasal" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>nasal</span></a>-spray <a href="https://faithcollapsing.com/tags/science" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>science</span></a> <a href="https://faithcollapsing.com/tags/snorestop" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>snorestop</span></a></p>
Giuseppe Michieli<p>Comparative Characterization of <a href="https://mstdn.science/tags/Bronchial" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Bronchial</span></a> and <a href="https://mstdn.science/tags/Nasal" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Nasal</span></a> <a href="https://mstdn.science/tags/Mucus" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Mucus</span></a> Reveals Key <a href="https://mstdn.science/tags/Determinants" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Determinants</span></a> of <a href="https://mstdn.science/tags/Influenza" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Influenza</span></a> A Virus <a href="https://mstdn.science/tags/Inhibition" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Inhibition</span></a> <a href="http://biorxiv.org/cgi/content/short/2024.09.17.613498v1?rss=1" rel="nofollow noopener noreferrer" translate="no" target="_blank"><span class="invisible">http://</span><span class="ellipsis">biorxiv.org/cgi/content/short/</span><span class="invisible">2024.09.17.613498v1?rss=1</span></a> </p><p>The ability of mucus to neutralize influenza A virus varies with the anatomical origin of the <a href="https://mstdn.science/tags/airway" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>airway</span></a> cultures and correlates with the abundance of <a href="https://mstdn.science/tags/triglycerides" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>triglycerides</span></a> and sialylated <a href="https://mstdn.science/tags/glycoproteins" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>glycoproteins</span></a> and <a href="https://mstdn.science/tags/glycolipids" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>glycolipids</span></a>.</p>
Giuseppe Michieli<p>A <a href="https://mstdn.science/tags/OneHealth" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>OneHealth</span></a> <a href="https://mstdn.science/tags/Investigation" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Investigation</span></a> into <a href="https://mstdn.science/tags/H5N1" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>H5N1</span></a> Avian <a href="https://mstdn.science/tags/Influenza" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Influenza</span></a> Virus <a href="https://mstdn.science/tags/Epizootics" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Epizootics</span></a> on 2 Dairy <a href="https://mstdn.science/tags/Farms" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Farms</span></a>, MedRxIV: <a href="https://www.medrxiv.org/content/10.1101/2024.07.27.24310982v1" rel="nofollow noopener noreferrer" translate="no" target="_blank"><span class="invisible">https://www.</span><span class="ellipsis">medrxiv.org/content/10.1101/20</span><span class="invisible">24.07.27.24310982v1</span></a> </p><p>We detected H5N1 HPAIV in 64% (9/14) of <a href="https://mstdn.science/tags/milk" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>milk</span></a> specimens, 2.6% (1/39) of cattle <a href="https://mstdn.science/tags/nasal" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>nasal</span></a> swab <a href="https://mstdn.science/tags/specimens" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>specimens</span></a>, and none of 17 cattle <a href="https://mstdn.science/tags/worker" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>worker</span></a> nasopharyngeal swab specimens... we detected <a href="https://mstdn.science/tags/SARS" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>SARS</span></a>-CoV-2 in a nasal swab from a sick <a href="https://mstdn.science/tags/cow" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>cow</span></a>... 14.3% (2/14) of farm workers who donated <a href="https://mstdn.science/tags/sera" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>sera</span></a> were recently symptomatic &amp; had elevated neutralizing <a href="https://mstdn.science/tags/antibodies" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>antibodies</span></a> against a related H5N1 strain.</p>
Giuseppe Michieli<p><a href="https://mstdn.science/tags/Cow" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Cow</span></a> “<a href="https://mstdn.science/tags/Challenge" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Challenge</span></a>” <a href="https://mstdn.science/tags/Study" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Study</span></a> Should Help Turn Tables on <a href="https://mstdn.science/tags/H5N1" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>H5N1</span></a> in Dairy <a href="https://mstdn.science/tags/Herds" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Herds</span></a>, <a href="https://mstdn.science/tags/USDA" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>USDA</span></a>: <a href="https://www.ars.usda.gov/news-events/news/research-news/2024/cow-challenge-study-should-help-turn-tables-on-h5n1-in-dairy-herds/" rel="nofollow noopener noreferrer" translate="no" target="_blank"><span class="invisible">https://www.</span><span class="ellipsis">ars.usda.gov/news-events/news/</span><span class="invisible">research-news/2024/cow-challenge-study-should-help-turn-tables-on-h5n1-in-dairy-herds/</span></a> </p><p>In the first study, the <a href="https://mstdn.science/tags/respiratory" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>respiratory</span></a> exposed <a href="https://mstdn.science/tags/heifers" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>heifers</span></a> became infected but showed minimal <a href="https://mstdn.science/tags/clinical" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>clinical</span></a> <a href="https://mstdn.science/tags/signs" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>signs</span></a> of disease, limited to an increased but sporadic <a href="https://mstdn.science/tags/nasal" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>nasal</span></a> discharge 1 to 3 days after infection. Lesions were observed in one heifer 7 days after infection.</p>
Giuseppe Michieli<p><a href="https://mstdn.science/tags/Nasal" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Nasal</span></a> <a href="https://mstdn.science/tags/tissue" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>tissue</span></a>-resident <a href="https://mstdn.science/tags/memory" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>memory</span></a> <a href="https://mstdn.science/tags/CD4" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>CD4</span></a>+ T cells persist after <a href="https://mstdn.science/tags/influenza" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>influenza</span></a> A virus <a href="https://mstdn.science/tags/infection" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>infection</span></a> and provide heterosubtypic <a href="https://mstdn.science/tags/protection" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>protection</span></a>, BioRxIV, <a href="https://www.biorxiv.org/content/10.1101/2024.07.06.602325v1" rel="nofollow noopener noreferrer" translate="no" target="_blank"><span class="invisible">https://www.</span><span class="ellipsis">biorxiv.org/content/10.1101/20</span><span class="invisible">24.07.06.602325v1</span></a> </p><p>Here, we find that, after IAV infection, antigen-specific CD4 TRM persist in the nasal tissue (NT) compartment and play a prime role in local viral clearance.</p>
Zoomers of the Sunshine Coast<p>NIH-sponsored trial of <br>nasal COVID-19 vaccine opens</p><p>Candidate vaccine could provide enhanced breadth of protection against emerging SARS-CoV-2 variants.</p><p>With the continual emergence of new virus variants, there is a critical need to develop next-generation COVID-19 vaccines, including nasal vaccines, that could reduce SARS-CoV-2 infections and transmission.</p><p><a href="https://mstdn.ca/tags/Nasal" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Nasal</span></a> <a href="https://mstdn.ca/tags/Vaccine" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Vaccine</span></a> <a href="https://mstdn.ca/tags/Transmission" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Transmission</span></a> </p><p><a href="https://www.nih.gov/news-events/news-releases/nih-sponsored-trial-nasal-covid-19-vaccine-opens" rel="nofollow noopener noreferrer" translate="no" target="_blank"><span class="invisible">https://www.</span><span class="ellipsis">nih.gov/news-events/news-relea</span><span class="invisible">ses/nih-sponsored-trial-nasal-covid-19-vaccine-opens</span></a></p>
Auscandoc<p>“The candidate, MPV/S-2P, uses a live-weakened version of a virus called murine pneumonia virus (MPV), which does not cause disease in humans.</p><p>MPV will deliver a stabilized version of the <a href="https://med-mastodon.com/tags/spike" class="mention hashtag" rel="tag">#<span>spike</span></a> protein, which the <a href="https://med-mastodon.com/tags/SARSCoV2" class="mention hashtag" rel="tag">#<span>SARSCoV2</span></a> virus, that causes <a href="https://med-mastodon.com/tags/COVID19" class="mention hashtag" rel="tag">#<span>COVID19</span></a>, uses to attach and infect human cells. This will teach the body to recognize the protein and train immune cells to attack if a person is infected.” <a href="https://med-mastodon.com/tags/vaccine" class="mention hashtag" rel="tag">#<span>vaccine</span></a> <a href="https://med-mastodon.com/tags/COVIDvaccine" class="mention hashtag" rel="tag">#<span>COVIDvaccine</span></a> <a href="https://med-mastodon.com/tags/nasal" class="mention hashtag" rel="tag">#<span>nasal</span></a> <a href="https://bird.makeup/users/meetjess/statuses/1808464414053724252" target="_blank" rel="nofollow noopener noreferrer" translate="no"><span class="invisible">https://</span><span class="ellipsis">bird.makeup/users/meetjess/sta</span><span class="invisible">tuses/1808464414053724252</span></a></p>
Giuseppe Michieli<p><a href="https://mstdn.science/tags/H9N2" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>H9N2</span></a> <a href="https://mstdn.science/tags/Influenza" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Influenza</span></a> A Viruses Found to be <a href="https://mstdn.science/tags/Enzootic" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Enzootic</span></a> in <a href="https://mstdn.science/tags/Punjab" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Punjab</span></a> <a href="https://mstdn.science/tags/Pakistan" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Pakistan</span></a>'s Bird <a href="https://mstdn.science/tags/Markets" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Markets</span></a> with Evidence of <a href="https://mstdn.science/tags/Human" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Human</span></a> H9N2 <a href="https://mstdn.science/tags/Nasal" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Nasal</span></a> <a href="https://mstdn.science/tags/Colonization" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Colonization</span></a>, Int J Infect Dis.: <a href="https://www.ijidonline.com/article/S1201-9712(24)00217-0/fulltext" rel="nofollow noopener noreferrer" translate="no" target="_blank"><span class="invisible">https://www.</span><span class="ellipsis">ijidonline.com/article/S1201-9</span><span class="invisible">712(24)00217-0/fulltext</span></a> </p><p>H9N2 IAV is likely enzootic in Punjab Province Pakistan's live bird markets and may be colonizing the noses of <a href="https://mstdn.science/tags/workers" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>workers</span></a> and market visitors. Regular monitoring for avian influenza-associated human illness in Punjab seems to be a needed public measure.</p>
Giuseppe Michieli<p><a href="https://mstdn.science/tags/Evolution" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Evolution</span></a> of <a href="https://mstdn.science/tags/nasal" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>nasal</span></a> and <a href="https://mstdn.science/tags/olfactory" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>olfactory</span></a> <a href="https://mstdn.science/tags/infection" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>infection</span></a> characteristics of <a href="https://mstdn.science/tags/SARS" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>SARS</span></a>-CoV-2 <a href="https://mstdn.science/tags/variants" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>variants</span></a> <a href="https://www.jci.org/articles/view/174439" rel="nofollow noopener noreferrer" translate="no" target="_blank"><span class="invisible">https://www.</span><span class="">jci.org/articles/view/174439</span><span class="invisible"></span></a> J Clin Invest. </p><p>Together, our study characterized the nasal <a href="https://mstdn.science/tags/tropism" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>tropism</span></a> of SARS-CoV-2 strains, immune <a href="https://mstdn.science/tags/clearance" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>clearance</span></a>, and <a href="https://mstdn.science/tags/regeneration" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>regeneration</span></a> after infection. The shifting characteristics of viral infection at the <a href="https://mstdn.science/tags/airway" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>airway</span></a> <a href="https://mstdn.science/tags/portal" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>portal</span></a> provide insight into the variability of COVID-19 clinical features, particularly long COVID, and may suggest differing strategies for early local intervention.</p>
kaffando<p>Question for the <a href="https://mastodon.social/tags/COVID19" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>COVID19</span></a> Brains Trust.</p><p>Does anyone know what's happening with <a href="https://mastodon.social/tags/nasal" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>nasal</span></a> sprays for reducing transmission in Australia? I know the excellent Don Campbell at Northern Health is working on one, but not sure where it's up to.<br>Thanks!<br>FYI <br><span class="h-card" translate="no"><a href="https://mastodon.social/@mackayim2022" class="u-url mention" rel="nofollow noopener noreferrer" target="_blank">@<span>mackayim2022</span></a></span> <span class="h-card" translate="no"><a href="https://aus.social/@mike_honey_" class="u-url mention" rel="nofollow noopener noreferrer" target="_blank">@<span>mike_honey_</span></a></span> <br><span class="h-card" translate="no"><a href="https://aus.social/@DenisCOVIDinfoguy" class="u-url mention" rel="nofollow noopener noreferrer" target="_blank">@<span>DenisCOVIDinfoguy</span></a></span></p>
Giuseppe Michieli<p>Enrichment of <a href="https://mstdn.science/tags/SARS" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>SARS</span></a>-CoV-2 <a href="https://mstdn.science/tags/sequence" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>sequence</span></a> from nasopharyngeal <a href="https://mstdn.science/tags/swabs" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>swabs</span></a> whilst identifying the <a href="https://mstdn.science/tags/nasal" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>nasal</span></a> <a href="https://mstdn.science/tags/microbiome" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>microbiome</span></a>, J Clin Virol.: <a href="https://doi.org/10.1016/j.jcv.2023.105620" rel="nofollow noopener noreferrer" translate="no" target="_blank"><span class="invisible">https://</span><span class="ellipsis">doi.org/10.1016/j.jcv.2023.105</span><span class="invisible">620</span></a></p>
Arniepix<p>Everything I Thought I Knew About <a href="https://masto.nyc/tags/Nasal" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Nasal</span></a> <a href="https://masto.nyc/tags/Congestion" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Congestion</span></a> Is Wrong</p><p><a href="https://masto.nyc/tags/nose" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>nose</span></a> <a href="https://masto.nyc/tags/breathing" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>breathing</span></a> <a href="https://masto.nyc/tags/medicine" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>medicine</span></a> <a href="https://masto.nyc/tags/science" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>science</span></a> <a href="https://masto.nyc/tags/Sinus" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Sinus</span></a> </p><p><a href="https://www.theatlantic.com/health/archive/2023/10/humans-have-two-noses-really/675823/" rel="nofollow noopener noreferrer" translate="no" target="_blank"><span class="invisible">https://www.</span><span class="ellipsis">theatlantic.com/health/archive</span><span class="invisible">/2023/10/humans-have-two-noses-really/675823/</span></a></p><p>&gt; Start with this: You really have two noses.</p>
Janice Selbie<p>We live in amazing days! <a href="https://mas.to/tags/science" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>science</span></a> <a href="https://mas.to/tags/medicine" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>medicine</span></a> #<a href="https://mas.to/tags/Nasal" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Nasal</span></a> <a href="https://mas.to/tags/alzheimers" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>alzheimers</span></a> drug effective regardless of <a href="https://mas.to/tags/brain" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>brain</span></a> <a href="https://mas.to/tags/plaque" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>plaque</span></a> levels <a href="https://newatlas.com/medical/nasal-alzheimers-drug-effective-regardless-of-brain-plaque-levels/?amp=true" rel="nofollow noopener noreferrer" target="_blank"><span class="invisible">https://</span><span class="ellipsis">newatlas.com/medical/nasal-alz</span><span class="invisible">heimers-drug-effective-regardless-of-brain-plaque-levels/?amp=true</span></a></p>
Stephen<p>Berlin scientists move closer to a nasal Covid vaccine which may be more effective than the intramuscular ones we have now.</p><p><a href="https://mastodon.green/tags/GoodNews" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>GoodNews</span></a> <a href="https://mastodon.green/tags/Covid" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Covid</span></a> <a href="https://mastodon.green/tags/Vaccine" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Vaccine</span></a> <a href="https://mastodon.green/tags/Nasal" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Nasal</span></a> <a href="https://mastodon.green/tags/Health" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Health</span></a> <a href="https://mastodon.green/tags/Care" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Care</span></a> <a href="https://mastodon.green/tags/Research" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Research</span></a> </p><p><a href="https://medicalxpress.com/news/2023-06-nasal-vaccine-coronavirus.html" rel="nofollow noopener noreferrer" target="_blank"><span class="invisible">https://</span><span class="ellipsis">medicalxpress.com/news/2023-06</span><span class="invisible">-nasal-vaccine-coronavirus.html</span></a></p>
Giuseppe Michieli<p><a href="https://mstdn.science/tags/Human" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Human</span></a> <a href="https://mstdn.science/tags/airway" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>airway</span></a> and <a href="https://mstdn.science/tags/nasal" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>nasal</span></a> <a href="https://mstdn.science/tags/organoids" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>organoids</span></a> reveal escalating replicative <a href="https://mstdn.science/tags/fitness" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>fitness</span></a> of <a href="https://mstdn.science/tags/SARS" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>SARS</span></a>-CoV-2 emerging <a href="https://mstdn.science/tags/variants" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>variants</span></a>, <a href="https://doi.org/10.1073/pnas.2300376120" rel="nofollow noopener noreferrer" target="_blank"><span class="invisible">https://</span><span class="ellipsis">doi.org/10.1073/pnas.230037612</span><span class="invisible">0</span></a></p>
Anita Y Cheng<p>An experiment with Syrian hamsters show that a live-attenuated <a href="https://mastodon.publicinterest.town/tags/nasal" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>nasal</span></a> <a href="https://mastodon.publicinterest.town/tags/vaccine" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>vaccine</span></a> performed better than injected Pfizer. The virus was cleared to undetectable levels 2 days after <a href="https://mastodon.publicinterest.town/tags/COVID" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>COVID</span></a> exposure. So there’s definitely something to vaccinating at a mucosal site where the virus is gonna replicate! Although the hosts also pointed out that durability will be something to seep an eye on - not even previous infection will maintain high mucosal antibodies. 11/</p><p> <a href="https://mastodon.publicinterest.town/tags/TWiVTLDR" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>TWiVTLDR</span></a></p>
Scientific Frontline<p>Scientists at the Cambridge Institute of Therapeutic <a href="https://mastodon.social/tags/Immunology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Immunology</span></a> and <a href="https://mastodon.social/tags/Infectious" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Infectious</span></a> Disease (CITIID) and Wellcome Sanger Institute showed that following <a href="https://mastodon.social/tags/SARS" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>SARS</span></a>-CoV-2 <a href="https://mastodon.social/tags/infection" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>infection</span></a>, cells in the lining of the <a href="https://mastodon.social/tags/lungs" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>lungs</span></a>, <a href="https://mastodon.social/tags/nasal" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>nasal</span></a> cells, and immune <a href="https://mastodon.social/tags/cells" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>cells</span></a> in the <a href="https://mastodon.social/tags/blood" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>blood</span></a> show a blunted inflammatory response in obese patients, producing suboptimal levels of <a href="https://mastodon.social/tags/molecules" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>molecules</span></a> needed to fight the infection.<br><a href="https://mastodon.social/tags/Covid19" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Covid19</span></a> <a href="https://mastodon.social/tags/Medical" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Medical</span></a> <a href="https://mastodon.social/tags/Biology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Biology</span></a> <a href="https://mastodon.social/tags/Virology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Virology</span></a> <a href="https://mastodon.social/tags/sflorg" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>sflorg</span></a><br><a href="https://www.sflorg.com/2023/03/med03202302.html" rel="nofollow noopener noreferrer" target="_blank"><span class="invisible">https://www.</span><span class="ellipsis">sflorg.com/2023/03/med03202302</span><span class="invisible">.html</span></a></p>