michael<p>21-Jul-2025<br><a href="https://mastodon.social/tags/Gecko" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Gecko</span></a>-inspired <a href="https://mastodon.social/tags/cancer" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>cancer</span></a> <a href="https://mastodon.social/tags/therapy" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>therapy</span></a> could lead to fewer side-effects, better patient outcomes<br>The new ultra-sticky particles can be loaded with <a href="https://mastodon.social/tags/chemotherapy" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>chemotherapy</span></a> drugs and attached to tumors, minimizing impact to healthy tissue </p><p><a href="https://www.eurekalert.org/news-releases/1091643" rel="nofollow noopener" translate="no" target="_blank"><span class="invisible">https://www.</span><span class="ellipsis">eurekalert.org/news-releases/1</span><span class="invisible">091643</span></a> <a href="https://mastodon.social/tags/science" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>science</span></a> <a href="https://mastodon.social/tags/medicine" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>medicine</span></a> <a href="https://mastodon.social/tags/biomimetic" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>biomimetic</span></a> <a href="https://mastodon.social/tags/nanoworld" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>nanoworld</span></a></p>
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23-Oct-2024
Little-studied #RNA might be key to regulating genetic disorders like #epilepsy, #autism
Future studies that manipulate this RNA could help treat neurodevelopmental diseases in humans
https://www.eurekalert.org/news-releases/1061951 #science #nanoworld #neuroscience #CellBiology
EurekAlert!Little-studied RNA might be key to regulating genetic disorders like epilepsy, autismWhen a gene produces too much protein, it can have devastating consequences on brain development and function. Patients with an overproduction of protein from the chromodomain helicase DNA binding (CHD2) gene can develop a rare and severe neurodevelopmental disorder that renders them wheelchair-bound, nonverbal and with profound intellectual delays.
Now, scientists at Northwestern Medicine and the Broad Institute of MIT and Harvard have discovered an RNA that acts like the brake in one’s car to control how much or how little protein is produced by a gene. In patients with this rare disorder, a long non-coding RNA called CHASERR (CHD2 adjacent, suppressive regulatory RNA) is deleted — the “foot” is taken off the “brake” — and CHD2 protein production goes into overdrive, reports a new Northwestern Medicine study.
The study will be published Oct. 23 in the New England Journal of Medicine.
25-Sep-2024
#Nanostructures in the deep ocean floor hint at life’s origin
https://www.eurekalert.org/news-releases/1059126 #science #OriginOfLife #astrobiology #nanoworld
EurekAlert!Nanostructures in the deep ocean floor hint at life’s originResearchers from the RIKEN Center for Sustainable Resource Science (CSRS) in Japan and The Earth-Life Science Institute (ELSI) of Tokyo Institute of Technology have discovered inorganic nanostructures surrounding deep-ocean hydrothermal vents that are strikingly similar to molecules that make life as we know it possible. These nanostructures are self-organized and act as selective ion channels, which create energy that can be harnessed in the form of electricity. Published Sep. 25 in Nature Communications, the findings impact not only our understanding of how life began, but can also be applied to industrial blue-energy harvesting.
28-Aug-2024
Shocking revelation: an electrically-activated protein regulates #spermatogenesis
Researchers from Osaka University find that a voltage-dependent phosphatase is crucial for translating electrical signals into chemical signals that promote proper #sperm maturation
Of course it takes a spark to make the love happen ...
https://www.eurekalert.org/news-releases/1056061 #science #physiology #proteins #nanoworld
EurekAlert!Shocking revelation: an electrically-activated protein regulates spermatogenesisResearchers from Osaka University found that voltage-sensing phosphatase (VSP) is activated by electrical signals during sperm maturation and is crucial for establishing the optimal phosphoinositide environment to generate functional spermatozoa. Modulating VSP function to promote appropriate sperm maturation could be used to develop clinical treatments for infertility in the future.
8-AUG-2024
Largest protein yet discovered builds algal #toxins
The findings could enhance monitoring efforts for harmful algal blooms, and unlock potential for new medicines or materials
<< how lovely that people are still discovering real things like #proteins
https://www.eurekalert.org/news-releases/1053949 #science #nanoworld #algae #ecology
EurekAlert!Largest protein yet discovered builds algal toxinsWhile seeking to unravel how marine algae create their chemically complex toxins, scientists at UC San Diego’s Scripps Institution of Oceanography have discovered the largest protein yet identified in biology. Uncovering the biological machinery the algae evolved to make its intricate toxin also revealed previously unknown strategies for assembling chemicals, which could unlock the development of new medicines and materials.
17-JUL-2024
#Llama #nanobodies: A breakthrough in building HIV immunity
Biology researchers at Georgia State have developed a new antibody therapy that can neutralize a wide variety of #HIV-1 strains. They found success in an unlikely source — llamas.
It's 24 years since I wrote my first articles about camel and llama #antibodies, so the PR people could tone down the "unlikely" a little bit.
https://www.eurekalert.org/news-releases/1051719 #science #nanoworld
EurekAlert!Llama nanobodies: A breakthrough in building HIV immunityBiology researchers at Georgia State have developed a new antibody therapy that can neutralize a wide variety of HIV-1 strains. They found success in an unlikely source — llamas.