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#nanoparticle

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Public
Giuseppe Michieli

#Immunogenicity & #biodistribution of lipid #nanoparticle formulated self-amplifying #mRNA #vaccines against #H5 avian #influenza, npj Vaccines: nature.com/articles/s41541-024

Cellular immune responses & #antigen-specific #IgA antibodies in #lungs were also observed. Comparison of sa-mRNA vaccines encoding secreted & membrane-anchored full-length HA revealed that anchoring of HA to the membrane significantly enhanced the antibody and cellular responses.

NatureImmunogenicity and biodistribution of lipid nanoparticle formulated self-amplifying mRNA vaccines against H5 avian influenza - npj VaccinesThis study reports on the immunogenicity and biodistribution of H5 hemagglutinin (HA)-based self-amplifying (sa) mRNA vaccines in mice. Four sa-mRNA vaccines encoding either a secreted full-length HA, a secreted HA head domain, a secreted HA stalk domain, or a full-length membrane-anchored HA were investigated. All vaccines elicited an adaptive immune response. However, the full-length HA sa-RNA vaccines demonstrated superior performance compared to head and stalk domain vaccines. The antibody titers positively correlated with the vaccine dose. Cellular immune responses and antigen-specific IgA antibodies in the lungs were also observed. The comparison of the sa-mRNA vaccines encoding the secreted and membrane-anchored full-length HA revealed that anchoring of the HA to the membrane significantly enhanced the antibody and cellular responses. In addition to the injection site, the intramuscularly injected sa-mRNA-LNPs were also detected in the draining lymph nodes, spleen, and to a lesser extent, in the lung, kidney, liver, and heart.
Public
Scientific Frontline

Treatment with the #nanoparticle reduced #ovarian #tumor growth by more than 50% in human cells and animal models. Women diagnosed with ovarian #cancer may initially respond well to #chemotherapy, but the majority of them will develop resistance to treatment and die from the disease.
#Medical #sflorg
sflorg.com/2024/02/med02222402

www.sflorg.comOutsmarting chemo-resistant ovarian cancerNew approach with nanoparticle starves cells of cholesterol and reduces tumor growth by 50%
Public
Scientific European

Lithium Battery for Electric Vehicles (EVs): Separators with coatings of Silica Nanoparticles enhance Safety  
Lithium-ion batteries for electric vehicles (EVs) face safety and stabilityissues due to overheating of separators, short circuits and reduced...........
#ElectricVehicles #EV #Lithium #LithiumBattery #Nanoparticle #Separators
Ume

scientificeuropean.co.uk/techn

Continued thread
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Lorraine

I’m really shite at explaining things. I shovel info into my brain, note what repeated actions practically I have to take or what to avoid & leave the rest. Explaining is not my gift which is why I love others whose gift it is🖤

His response: (which came really quickly I might add🥰😍)

“No studies have been performed to measure nanoparticle-spike persistence in local or distal tissues”

And no studies have tested whether there’s a blue teapot orbiting Jupiter either (scientist snark) Point is that sure, this could be an issue. Sure, the nanos could also infest your brain, or it could this or that, but that doesn’t invalidate anything. This is FUD, (fear, uncertainty & doubt) - not invalid, but not a valid issue

“ ◦#Novavax expects a low potential for serious unwanted effects and toxicities in neonates, infants, and children” (they don’t know)
◦ “Novavax expects a low potential for serious unwanted effects and toxicities in pregnant women and fetuses” (they don’t know)
◦ “Novavax does not believe there are other special populations which would be more susceptible for serious unwanted effects and toxicities” (they don’t know)”

This is just dumb - who is this guy? Probably a MD, they think they understand science. Science doesn’t find Truth, it discovers truth. It will never be all encompassing. Short answer, we always will know less than can be known, so saying “they don’t know” is just asinine, of course they don’t! They can’t.

Addendum - studies cherry pick, you have to there’s never enough time or money. They studied the big issues, doubtful these are anything which is why they weren’t studied, and for darn sure getting COVID is worse (dumbass)

biodistribution of Novavax nanoparticle-spike has never been done and company “assumes” that it “mostly” stays in local lymph nodes because it should behave like a “conventional protein antigen” (it’s NOT, it’s a nanoparticle)

This looks like scare mongering, he doesn’t say anything but the word NANOPARTICLE is supposed to inspire fear, or something. A null statement.

OK

ALSO contains a saponin-based #MatrixM #adjuvant (40nm #nanoparticle, remarkably stable, held together by saponin-cholesterol interactions” (in rodents causes decreased body weight and red cell mass) – “may contribute to immunotoxicity”

This also is stupid - ask **** about how many times she’s heard **** or I say ANYTHING for certain - we don’t. We qualify everything. Built into techy types, we know nothing is known for 100% certainty - if you want that go join a religion

Yeah that’s probably enough too much to bother with, another technique FUD masters use is loooong, highly detailed posts that look smart and scientific, but it’s part of the advertising. Real scientists cut it short - that’s why there’s a précis/summary at the top. Get the idea in a paragraph and read the rest if you care

-End

Also his response to my Halloween wishes cracked me up🎃

Alas, must continue on that ball gown pattern I started yesterday (wrap apron dress but put anything poufy underneath instant ball gown) hence goblin trick 2 for tomorrow. These goblins & ghouls are so draining

Response to happy Halloween wishes Thanks for the reminder to turn all the lights off tonight :)
Public
Scientific European

Chemistry Nobel Prize 2023 for the discovery and synthesis of Quantum dots  
This year’s Nobel Prize in Chemistry has been awarded jointly to Moungi Bawendi, Louis Brus and Alexei Ekimov “for the discovery and synthesis of...........
#Nanoparticle #Nanotechnology #Nobelprize #NobelPrizeinChemistry #QLEDtechnology #Quantumdots #Quantumeffect #Semiconductor
Umes

scientificeuropean.co.uk/scien

Public
katch wreck

"For induction of photothermal assembly around targeted living cells in cell culture medium, infrared continuous-wave laser light was focused onto high-density gold-particle-bound glass bottom dishes exhibiting plasmonic superradiance or thin gold-film-coated glass bottom dishes. In this system, the biofunctional molecules can be concentrated around the targeted living cells and internalized into them only by 100 s laser irradiation"
pubs.acs.org/doi/10.1021/acs.n

#laser#nanoparticle#drugDelivery
Public
Thomas Moore

I guess it's customary to make an #introduction post:

I'm a postdoctoral researcher at the #IstitutoItalianoDiTecnologia. My background is #nanomedicine #drugdelivery and #bionanointeractions. Currently working on #nanoparticle delivery across the blood--brain barrier for treating neurodevelopmental diseases. Originally from the U.S. but have been living and working in Europe for close to a decade.

I don't think that Twitter will ultimately die, but I'm a big fan of #FOSS.

#academia#science
Public
Freckled Science

Hi! #introduction ! I am a #phd student in #chemistry in #vancouver ! I study #nanoparticle #liquidcrystal self-assembly, which has implications in our understandings of #biology nanostructures, #materials chemistry, and #nanotechnology

I’ve been #scicomm ing my #research live on #twitch where I am developing #3dprinting inks made from seaweed and other #biomaterials !

I also interview scientists weekly, so if you are ever interested, let me know! I’d love to have you as a guest!

#phdchat#academic#academia
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