katch wreck<p>"deletion of..Mitofusin2 (MFN2), which serves as a tether for MAM, in human induced pluripotent stem (iPS) cells or the reduction of MAM in differentiated <a href="https://mastodon.social/tags/myotubes" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>myotubes</span></a> caused by microgravity..increased susceptibility to <a href="https://mastodon.social/tags/muscle" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>muscle</span></a> <a href="https://mastodon.social/tags/atrophy" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>atrophy</span></a>, as well as the activation of..Notch..The atrophic phenotype..in microgravity & the regenerative capacity of Mfn2-deficient muscle stem cells in dystrophic mice were both ameliorated by treatment with the gamma-secretase inhibitor DAPT"</p><p><a href="https://elifesciences.org/articles/89381" rel="nofollow noopener noreferrer" translate="no" target="_blank"><span class="invisible">https://</span><span class="ellipsis">elifesciences.org/articles/893</span><span class="invisible">81</span></a></p>