Giuseppe Michieli<p>Development of <a href="https://mstdn.science/tags/DNA" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>DNA</span></a> and <a href="https://mstdn.science/tags/mRNA" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>mRNA</span></a>-LNP <a href="https://mstdn.science/tags/vaccines" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>vaccines</span></a> against an <a href="https://mstdn.science/tags/H5N1" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>H5N1</span></a> clade 2.3.4.4b <a href="https://mstdn.science/tags/influenza" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>influenza</span></a> virus, <a href="https://etidiohnew.blogspot.com/2025/07/development-of-dna-and-mrna-lnp.html" rel="nofollow noopener" translate="no" target="_blank"><span class="invisible">https://</span><span class="ellipsis">etidiohnew.blogspot.com/2025/0</span><span class="invisible">7/development-of-dna-and-mrna-lnp.html</span></a></p>
Administered by:
#mrna
7 posts6 participants0 posts today
‘Tremendous uncertainty’ for cancer research as US officials target #mRNA vaccines - https://www.theguardian.com/us-news/2025/jul/12/mrna-vaccine-cancer-research-trump-administration idiot #trump wants to #MCGA: Make Cancer Great Again...
The Guardian · ‘Tremendous uncertainty’ for cancer research as US officials target mRNA vaccines
mRNA 3′UTRs chaperone intrinsically disordered regions to control protein activity.
#RNA #mRNA #3UTR #IntrinsicallyDisorderedRegions #IDRs #IntrinsicallyDisorderedProteins #Chaperones #Preprint
bioRxiv · mRNA 3′UTRs chaperone intrinsically disordered regions to control protein activityMore than 2,700 human mRNA 3′UTRs have hundreds of highly conserved (HC) nucleotides, but their biological roles are unclear. Here, we show that mRNAs with HC 3′UTRs mostly encode proteins with long intrinsically disordered regions (IDRs), including MYC, UTX, and JMJD3. These proteins are only fully active when translated from mRNA templates that include their 3′UTRs, raising the possibility of functional interactions between 3′UTRs and IDRs. Rather than affecting protein abundance or localization, we find that HC 3′UTRs control transcriptional or histone demethylase activity through co-translationally determined protein oligomerization states that are kinetically stable. 3′UTR-dependent changes in protein folding require mRNA-IDR interactions, suggesting that mRNAs act as IDR chaperones. These mRNAs are multivalent, a biophysical RNA feature that enables their translation in network-like condensates, which provide favorable folding environments for proteins with long IDRs. These data indicate that the coding sequence is insufficient for the biogenesis of biologically active conformations of IDR-containing proteins and that RNA can catalyze protein folding.
### Competing Interest Statement
The authors have declared no competing interest.
Pershing Square Foundation, https://ror.org/04tce9s05
G. Harold & Leila Y. Mathers Foundation
National Institutes of Health, DP1GM123454, R35GM144046
Memorial Sloan Kettering Cancer Center, https://ror.org/02yrq0923, P30 CA008748
Efficacy, immunogenicity, and safety of a next-generation #mRNA-1283 #COVID19 #vaccine compared with mRNA-1273 vaccine (NextCOVE)..., https://etidiohnew.blogspot.com/2025/07/efficacy-immunogenicity-and-safety-of.html
etidiohnew.blogspot.comEfficacy, immunogenicity, and safety of a next-generation #mRNA-1283 #COVID19 #vaccine compared with mRNA-1273 vaccine (NextCOVE)...
Replied in thread
@holeinthehead2
Tens of thousands? Ha. Their Vax policies will kill COVID level fatalities. Even without a pandemic: we are so close to #mRNA protecting us from many cancers.
"An #mRNA-based seasonal #flu #vaccine from #Moderna was 27 percent more effective at preventing influenza infections than a standard flu shot..." https://arstechnica.com/health/2025/07/moderna-says-its-mrna-seasonal-flu-shot-is-27-better-than-current-vaccine/
Ars Technica · Moderna says mRNA flu vaccine sailed through trial, beating standard shot
Sen. Cassidy finally grew a pair!
“Although the appointees to [the Advisory Committee for Immunization Practices] have scientific credentials, many do not have significant experience studying microbiology, #epidemiology or #immunology. In particular, some lack experience studying new technologies such as #mRNA #vaccines, and may even have a preconceived bias against them,” Sen. Bill Cassidy (R-La.) wrote on the social media site X Monday evening. (paywalled)
STAT · Cassidy calls to delay meeting of CDC's vaccine panel in challenge to RFK Jr.A key GOP senator is calling for the CDC's vaccine meeting to be postponed after RFK Jr. shook up the panel.
Dr. Judy Stone has an update at Forbes about #vaccine policy since #RFKJr replaced longstanding #CDC advisors: "Kennedy has previously lied about #mRNA vaccines. He has unilaterally delayed and limited #COVID19 vaccines and is demanding unethical blinded trials be done in the future. It is likely that the new #ACIP members will further restrict the vaccines. We also won’t have a #BirdFlu vaccine for the foreseeable future because of their fears about mRNA vaccines." https://www.forbes.com/sites/judystone/2025/06/23/what-to-expect-as-the-new-vaccine-advisory-committee-meets-this-week/
ForbesWhat To Expect As The New Vaccine Advisory Committee Meets This WeekRobert F. Kennedy, Jr's new ACIP vaccine advisors are likely to undo years of evidence-based recommendations. Here's what's at stake.
Replied in thread
@CaroleDuckyIrPsych
I mourn the lives lost to cancer from US’s current hiccup in #mRNA research. Sure hope Kennedy, Murdoch, or Trump don’t get cancer!
#Vaccini #mRNA anticancro: la svolta europea sui tumori solidi
I vaccini mRNA, da strumento di emergenza, si stanno trasformando in terapie intelligenti e personalizzate, capaci di dialogare con il nostro sistema immunitario in modi mai visti prima. L’Europa,per una volta, non rincorre gli Stati Uniti, ma li affianca nella corsa (e forse li supera: NDR)
“questa è solo la prima fase, ma la risposta immunitaria che stiamo osservando ci dice che siamo sulla strada giusta”
https://italia-informa.com/salute-anti-cancro-anticancro-vaccini-mrna-scoperta-tumori-solidi.aspx
italia-informa.com · Vaccini mRNA anticancro: la svolta europea sui tumori solidi
Replied in thread
@flexghost the #USA is likely gonna ban any #mRNA #vaccines soon, so yeah, they'll likely paywall it for like $2,5M and require RFK Jr. himself to personally sign a permit to be allowed to get treatment!
The people who think COVID was a Chinese bio attack are also OK with letting China take the lead in #mRNA research.
What is it about vaccines and Republicans?
As top US health officials turn against some mRNA vaccines, experts fear for the country’s preparedness for the next pandemic and worry that other vaccines will be targeted next.
https://www.theguardian.com/us-news/2025/jun/14/mrna-vaccines-trump-rfk-jr
In addition to claiming the Covid vaccines are deadly, Kennedy has “also said no vaccine is beneficial”
The Guardian · US experts fear all vaccines at risk as Trump officials target mRNA jabs
www.msn.comMSN