Med-Mastodon

Rxiv mechanobio📰 "Liquid-Liquid Phase Separation-Mediated Cellular-Scale Compartmentalization of Hydrogel Covalent Cross-Linking Promotes Microtubule-Based Mechanosensing" <a href="https://doi.org/doi:10.1021/jacs.5c00079" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://doi.org/doi:10.1021/jacs.5c00079</a> <a href="https://pubmed.ncbi.nlm.nih.gov/40252026/" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://pubmed.ncbi.nlm.nih.gov/40252026/</a> <a href="https://biologists.social/tags/Mechanosensing" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Mechanosensing</a> <a href="https://biologists.social/tags/Extracellular" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Extracellular</a> <a href="https://biologists.social/tags/Microtubule" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Microtubule</a> <a href="https://biologists.social/tags/Mechanical" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Mechanical</a>

Rxiv mechanobio📰 "Microtubule-driven cell shape changes and actomyosin flow synergize to position the centrosome" <a href="https://doi.org/doi:10.1083/jcb.202405126" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://doi.org/doi:10.1083/jcb.202405126</a> <a href="https://pubmed.ncbi.nlm.nih.gov/40243666/" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://pubmed.ncbi.nlm.nih.gov/40243666/</a> <a href="https://biologists.social/tags/Extracellular" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Extracellular</a> <a href="https://biologists.social/tags/Microtubule" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Microtubule</a> <a href="https://biologists.social/tags/Mechanical" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Mechanical</a>

Rxiv mechanobio📰 "Tekt3 Safeguards Proper Functions and Morphology of Neuromast Hair Bundles" <a href="https://doi.org/doi:10.3390/ijms26073115" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://doi.org/doi:10.3390/ijms26073115</a> <a href="https://pubmed.ncbi.nlm.nih.gov/40243732/" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://pubmed.ncbi.nlm.nih.gov/40243732/</a> <a href="https://biologists.social/tags/Microtubule" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Microtubule</a> <a href="https://biologists.social/tags/Mechanical" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Mechanical</a>

Rxiv mechanobio📰 "Rethinking tubulin acetylation: From regulation to cellular adaptation" <a href="https://doi.org/doi:10.1016/j.ceb.2025.102512" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://doi.org/doi:10.1016/j.ceb.2025.102512</a> <a href="https://pubmed.ncbi.nlm.nih.gov/40220734/" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://pubmed.ncbi.nlm.nih.gov/40220734/</a> <a href="https://biologists.social/tags/Microtubule" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Microtubule</a> <a href="https://biologists.social/tags/Mechanical" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Mechanical</a>

Rxiv mechanobio📰 "Peptide-mediated display of Tau-derived peptide for construction of microtubule superstructures" <a href="https://doi.org/doi:10.1039/d4cb00290c" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://doi.org/doi:10.1039/d4cb00290c</a> <a href="https://pubmed.ncbi.nlm.nih.gov/40162136/" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://pubmed.ncbi.nlm.nih.gov/40162136/</a> <a href="https://biologists.social/tags/Microtubule" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Microtubule</a> <a href="https://biologists.social/tags/Mechanical" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Mechanical</a> <a href="https://biologists.social/tags/Cell" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Cell</a>

Rxiv mechanobio📰 "Microtubule Deformation Modulates Intracellular Transport by Kinesin Differently than Dynein" <a href="https://doi.org/doi:10.1109/TNB.2024.3507021" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://doi.org/doi:10.1109/TNB.2024.3507021</a> <a href="https://pubmed.ncbi.nlm.nih.gov/40030316/" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://pubmed.ncbi.nlm.nih.gov/40030316/</a> <a href="https://biologists.social/tags/Microtubule" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Microtubule</a> <a href="https://biologists.social/tags/Mechanical" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Mechanical</a> <a href="https://biologists.social/tags/Cell" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Cell</a>

Rxiv mechanobio📰 "Control of the force-bearing properties of microtubule-associated proteins via stalk/linker regions: insights from the NDC80 complex" <a href="https://www.biorxiv.org/content/10.1101/2025.02.12.637486v1?rss=1" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://www.biorxiv.org/content/10.1101/2025.02.12.637486v1?rss=1</a> <a href="https://biologists.social/tags/Microtubule" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Microtubule</a> <a href="https://biologists.social/tags/Mechanical" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Mechanical</a> <a href="https://biologists.social/tags/Force" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Force</a>

Jocelyn Etienne<a href="https://biologists.social/@Rxiv_mechanobio" class="u-url mention" rel="nofollow noopener noreferrer" target="_blank">@Rxiv_mechanobio</a> Interesting review !"Far from being homogeneous beams, cytoskeletal filaments have complex mechanical properties, which are directly related to the specific structural arrangement of their subunits. They are also versatile, as the filaments’ mechanics and biochemistry are tightly coupled, and their properties can vary with the cellular context."<a href="https://scicomm.xyz/tags/actin" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#actin</a> <a href="https://scicomm.xyz/tags/microtubule" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#microtubule</a> <a href="https://scicomm.xyz/tags/vimentin" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#vimentin</a>

Rxiv mechanobio📰 "Liquid-solid coexistence at single fibril resolution during tau condensate ageing" <a href="https://www.biorxiv.org/content/10.1101/2025.02.06.636870v1?rss=1" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://www.biorxiv.org/content/10.1101/2025.02.06.636870v1?rss=1</a> <a href="https://biologists.social/tags/Microtubule" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Microtubule</a> <a href="https://biologists.social/tags/Mechanical" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Mechanical</a>

Rxiv mechanobio📰 "Tubulin Acetylation Enhances Microtubule Stability in Trabecular Meshwork Cells Under Mechanical Stress" <a href="https://doi.org/doi:10.1167/iovs.66.1.43" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://doi.org/doi:10.1167/iovs.66.1.43</a> <a href="https://pubmed.ncbi.nlm.nih.gov/39820277/" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://pubmed.ncbi.nlm.nih.gov/39820277/</a> <a href="https://biologists.social/tags/Microtubule" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Microtubule</a> <a href="https://biologists.social/tags/Mechanical" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Mechanical</a> <a href="https://biologists.social/tags/Cell" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Cell</a>

Rxiv mechanobio📰 "Microtubule acetylation is not required for HIV-1 infection or TRIM69-mediated restriction of HIV-1 infection" <a href="https://doi.org/doi:10.1128/jvi.01026-24" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://doi.org/doi:10.1128/jvi.01026-24</a> <a href="https://pubmed.ncbi.nlm.nih.gov/39804091/" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://pubmed.ncbi.nlm.nih.gov/39804091/</a> <a href="https://biologists.social/tags/Microtubule" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Microtubule</a> <a href="https://biologists.social/tags/Mechanical" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Mechanical</a>

PLOS BiologyA previous study in <a href="https://fediscience.org/tags/plosbiology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#plosbiology</a> found that Wnt receptors are housed in early endosomes and required for dendritic <a href="https://fediscience.org/tags/microtubule" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#microtubule</a> nucleation. This Update Article shows that microtubule dynamics in <a href="https://fediscience.org/tags/dendrites" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#dendrites</a> can be influenced non-autonomously by surrounding epithelial cells plos.io/3DK0M0J

Rxiv cytoskeleton📰 "Optogenetically Induced Microtubule Acetylation Unveils the Molecular Dynamics of Actin-Microtubule Crosstalk in Directed Cell Migration" <a href="http://biorxiv.org/cgi/content/short/2024.12.01.626286v1?rss=1" rel="nofollow noopener noreferrer" translate="no" target="_blank">http://biorxiv.org/cgi/content/short/2024.12.01.626286v1?rss=1</a> <a href="https://biologists.social/tags/Microtubule" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Microtubule</a>

Rxiv cytoskeleton📰 "CAMSAP3 forms dimers via its alpha-helix domain that directly stabilize non-centrosomal microtubule minus ends" <a href="https://pubmed.ncbi.nlm.nih.gov/39479887/" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://pubmed.ncbi.nlm.nih.gov/39479887/</a> <a href="https://botsin.space/tags/Cytoskeleton" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Cytoskeleton</a> <a href="https://botsin.space/tags/Microtubule" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Microtubule</a>

PLOS BiologyArl2 regulates asymmetric division in fly neural stem cells via control of <a href="https://fediscience.org/tags/microtubule" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#microtubule</a> growth. @HongyanWang9 &co show that, in mammalian <a href="https://fediscience.org/tags/cortex" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#cortex</a>, Arl2 binds to Cdk5rap2 to control microtubule growth, so regulating <a href="https://fediscience.org/tags/corticogenesis" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#corticogenesis</a> <a href="https://fediscience.org/tags/PLOSBiology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#PLOSBiology</a> <a href="https://plos.io/4dqDo5q" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://plos.io/4dqDo5q</a>

PLOS BiologyMutations in <a href="https://fediscience.org/tags/microtubule" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#microtubule</a> regulatory protein Katnal2 have been linked to <a href="https://fediscience.org/tags/autism" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#autism</a>. This study finds that loss of Katnal2 in mice leads to autism-related phenotypes, driven in part by altered <a href="https://fediscience.org/tags/ciliary" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#ciliary</a> function in the lateral <a href="https://fediscience.org/tags/ventricles" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#ventricles</a> <a href="https://fediscience.org/tags/PLOSBiology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#PLOSBiology</a> <a href="https://plos.io/4aezHNy" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://plos.io/4aezHNy</a>

PLOS BiologyCFDP1 regulates cell proliferation & higher-order <a href="https://fediscience.org/tags/chromatin" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#chromatin</a> structure. This study shows that CFDP1 is essential for structural stability of centromeric <a href="https://fediscience.org/tags/heterochromatin" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#heterochromatin</a>, so influencing <a href="https://fediscience.org/tags/microtubule" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#microtubule</a> nucleation during <a href="https://fediscience.org/tags/MitoticSpindle" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#MitoticSpindle</a> formation <a href="https://fediscience.org/tags/PLOSBiology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#PLOSBiology</a> <a href="https://plos.io/3W5eFhc" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://plos.io/3W5eFhc</a>

mechanochemistryCalling <a href="https://mstdn.science/tags/Microtubule" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Microtubule</a> enthusiasts and cytoskeletonistas!The UK Microtubule Meeting is on 13th May 2024 in Edinburgh. Organised by Julie Welburn, Andrew Carter and Mark Dodding.<a href="https://www.ed.ac.uk/biology/microtubule" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://www.ed.ac.uk/biology/microtubule</a>

PLOS BiologyAnti-cancer activity of microtubule-targeted drugs is assumed to occur via mitotic arrest. This study reveals that diverse <a href="https://fediscience.org/tags/microtubule" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#microtubule</a> poisons instead exert <a href="https://fediscience.org/tags/AntiCancer" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#AntiCancer</a> effects due to aberrant transit through <a href="https://fediscience.org/tags/mitosis" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#mitosis</a> without mitotic arrest <a href="https://fediscience.org/tags/PLOSBiology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#PLOSBiology</a> <a href="https://plos.io/3MmTKR3" rel="nofollow noopener noreferrer" target="_blank">https://plos.io/3MmTKR3</a>

katch wreck`Prof. Gunning says we now know that this mechanism arises because the <a href="https://mastodon.social/tags/cancer" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#cancer</a> cells activate a signal that recognises <a href="https://mastodon.social/tags/microtubule" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#microtubule</a> fragmentation and causes the arms to reach toward the edge of the cell and pull on the cortex to bring the fragments back together.“This allows the arms to stabilise and generate the force necessary to physically grab and pull the <a href="https://mastodon.social/tags/chromosomes" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#chromosomes</a> into each daughter cell and ensure the cancer cell multiplies.”` <a href="https://www.cell.com/current-biology/fulltext/S0960-9822(23)01268-X" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://www.cell.com/current-biology/fulltext/S0960-9822(23)01268-X</a>

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