No road? No problem! Squeezing through cell tunnels helps leukocytes reach their target sites

Felipe Del Valle Batalla highlights a recent, highly collaborative #preprint revealing a previously unrecognised level of complexity in leukocyte trafficking. #NoursharghLab @JoachimGoedhart #VanBuul_lab

Check out his #preLight

https://prelights.biologists.com/highlights/leukocytes-use-endothelial-membrane-tunnels-to-extravasate-the-vasculature/

"We propose that WNK1-induced water entry is required to swell the #membrane at the leading edge, generating space into which #actin filaments can polymerize, thereby facilitating forward movement of the cell. Given the broad expression of WNK1 pathway proteins, our study suggests that ion and water influx are likely to be essential for migration in many cell types, including #leukocytes and metastatic #tumor cells."

https://www.nature.com/articles/s41467-023-43423-8

A brief compilation of these years sharing about #CellMigration, #Organelles #Leukocytes & more...

With the @cellcommlab we'll keep transmitting from http://mstdn.science if you want to follow our new sci adventures !

@AnhHLe2702 @tlnagy @robinsall hahaha
well actually we are already pretty much generating our gradient, just like #leukocytes even if it's not yet shown...