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#lassa

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Public
Giuseppe Michieli

#Italy, #traveler from #DRC tested negative after molecular diagnostics performed, iltirreno.it/lucca/cronaca/202

Patient was negative for #Alphavirus, #Flavivirus, #RVF, #Lassa, #influenza A, influenza B, #SARS-CoV-2, #rhinovirus, NL63, 229E, OC43 e HKU1, PIV 1, 2, 3 e 4, #metapneumovirus A/B, #bocavirus, #RSV A/B, #adenovirus, #parechovirus, Borrelia spp, Borrelia recurrentis, Borrelia duttoni, Borrelia TBRF group, Bartonella spp, Erlichia spp, Rickettsia spp, virus del morbillo, Plasmodium spp.

Il TirrenoLucca, test negativi sul paziente rientrato dal CongoL’esito degli esami del sangue dopo il ricovero per febbre del 50enne lucchese
Public
Giuseppe Michieli

#France, Un cas de fièvre de #Lassa confirmé en Île-de-France : les autorités sanitaires pleinement mobilisées sante.gouv.fr/actualites/press

The Ministry of Labor, Health and Solidarity was informed on May 1, 2024 of a confirmed case of Lassa fever. The patient, a soldier returning from abroad, was hospitalized in Ile-de-France. His state of health does not cause concern. A thorough epidemiological investigation is underway to determine the people who may have been in risky contact with the patient.

Ministère du travail, de la santé et des solidarités · Un cas de fièvre de Lassa confirmé en Île-de-France : les autorités sanitaires pleinement mobilisées – Ministère du travail, de la santé et des solidaritésLe ministère du Travail, de la Santé et des Solidarités a été informé le 1er mai 2024 d'un cas confirmé de fièvre de Lassa. Le patient, un militaire revenant de l'étranger, a été hospitalisé en…
Public
Thiago Carvalho

'To address this critical knowledge gap, we conducted a comprehensive cross-species analysis of transcriptomic data from over 6000 blood samples from macaques and humans infected with one of 31 viruses, including #Lassa, #Ebola, #Marburg, #Zika, and #dengue.'
#Immunology #Virology #preprint

biorxiv.org/content/10.1101/20

bioRxivSystems immunology of transcriptional responses to viral infection identifies conserved antiviral pathways across macaques and humansViral pandemics and epidemics pose a significant global threat, with emerging and re-emerging viruses responsible for four pandemics in the 21st century alone. While macaques have been utilized as a model for understanding viral disease in a controlled setting, it remains unclear how conserved the antiviral responses to diverse viruses are between macaques and humans. To address this critical knowledge gap, we conducted a comprehensive cross-species analysis of transcriptomic data from over 6000 blood samples from macaques and humans infected with one of 31 viruses, including Lassa, Ebola, Marburg, Zika, and dengue. Our findings demonstrate that irrespective of primate or viral species, there are conserved antiviral responses which are consistent regardless of infection phase (acute, chronic, or latent) and viral genome type (DNA or RNA viruses). Moreover, by leveraging longitudinal data from experimental challenges, we identified virus-specific response dynamics such as host responses to Coronaviridae and Orthomyxoviridae infections peaking 1-3 days earlier than responses to Filoviridae and Arenaviridae viral infections. Additionally, through comparative analysis of immune responses across viruses, we identified a unique enrichment of lymphoid cellular response modules in macaque Flaviviridae infection that persists in human responses to dengue. Our results underscore macaque studies as a powerful tool for gaining new insights into viral pathogenesis and immune responses that translate to humans, which can inform viral therapeutic development and enable pandemic preparedness. ### Competing Interest Statement P.K. is a shareholder and a consultant to Inflammatix, Inc.
Public
BNITM

Point-of-care ultrasound #POCUS is possibly a promising low-cost imaging technique to manage most-at-risk #Lassa Fever patients.
Check out this study by @CyrilErameh @ISTH_Irrua & @infektiodoc @UKEHamburg & al. @BNITM_de publ. in the #Journal_of_Infection:
bit.ly/3mLHgbX
---
RT @infektiodoc
Can point-of-care ultrasound be a helpful tool in the management of Lassa fever patients? – a 🧵 1/9

#POCUS
#Lassafever🐀🦠🤒
#Nigeria 🇳🇬

htt…
twitter.com/infektiodoc/status

Three figures: 1. showing the modes of transmission of Lassa Virus to humans from Mastomys rodents, contaminated food or between humans. A globe shows Nigeria as endemic area. 2. showing a graphic with a point-of-care ultrasound and a patient 3. showing an ultrasound. ©Journal of infection
Public *
Noam Ross

A new paper by @davidsimons: "Lassa fever cases suffer from severe underreporting based on reported fatalities."

Using current estimates of case fatality and severe outcome rates, he calculates the gap between expected and reported sever cases: "The expected number of severe cases between 2012 and 2022 is 8995, with current reported numbers 58% of what is expected."

academic.oup.com/inthealth/adv

@epiverse #epiverse #epidemiology #lassa #zoonoses

Figure 1 from paper "Lassa fever cases suffer from severe underreporting based on reported fatalities". A graph showing distributions of case fatality rates using density (or raincloud) plots, as calculated by three methods, and bar plots showing the absolute value and ratio of reported and exected cases for seven countries, ranging from a ratio 17% (Ghana) to a ratio of 63% (Nigeria). Caption of of figure: "CFR of Lassa fever following development of symptomatic disease and presenting to healthcare using three data sources for estimation. Method 1 uses all reported cases and deaths where the CFR is not equal to 0% or 100%. Method 2 uses all reported cases and deaths provided by NCDC data prior to 2021 where the CFR is not equal to 0% or 100%. Method 3 uses all reported cases and deaths from Edo and Ondo states from 2017 to 2021. The black line represents the weighted mean CFR. (B) The difference between reported cases and expected cases derived from the number of reported deaths divided by the CFR (note that the y-axis scale varies by country)."
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