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#Heme

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CellBioNews<p>How <a href="https://scientificnetwork.de/tags/Staphylococcus" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Staphylococcus</span></a> aureus 'steals' <a href="https://scientificnetwork.de/tags/iron" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>iron</span></a> from our <a href="https://scientificnetwork.de/tags/blood" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>blood</span></a> during infections.</p><p><a href="https://scientificnetwork.de/tags/kleptophagy" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>kleptophagy</span></a> <a href="https://scientificnetwork.de/tags/kleptoparasitism" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>kleptoparasitism</span></a> <a href="https://scientificnetwork.de/tags/heme" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>heme</span></a> </p><p> <a href="https://phys.org/news/2025-02-staphylococcus-aureus-iron-blood-infections.html" rel="nofollow noopener" translate="no" target="_blank"><span class="invisible">https://</span><span class="ellipsis">phys.org/news/2025-02-staphylo</span><span class="invisible">coccus-aureus-iron-blood-infections.html</span></a></p>
Rhyothemis<p>old but interesting research article [2017]:</p><p>Extracellular glycine is necessary for optimal hemoglobinization of erythroid cells<br><a href="https://pmc.ncbi.nlm.nih.gov/articles/PMC5541866/" rel="nofollow noopener" translate="no" target="_blank"><span class="invisible">https://</span><span class="ellipsis">pmc.ncbi.nlm.nih.gov/articles/</span><span class="invisible">PMC5541866/</span></a></p><p>"Vertebrate heme synthesis requires three substrates: succinyl-CoA, which regenerates in the tricarboxylic acid cycle, iron and glycine. For each heme molecule synthesized, one atom of iron and eight molecules of glycine are needed."</p><p><a href="https://zeroes.ca/tags/biology" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>biology</span></a> <a href="https://zeroes.ca/tags/biochemistry" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>biochemistry</span></a> <a href="https://zeroes.ca/tags/heme" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>heme</span></a> <a href="https://zeroes.ca/tags/RBCs" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>RBCs</span></a> <a href="https://zeroes.ca/tags/glycine" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>glycine</span></a> <a href="https://zeroes.ca/tags/anemia" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>anemia</span></a></p>
Hao Yin<p><a href="https://qoto.org/tags/Heme" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Heme</span></a> biosynthesis <a href="https://qoto.org/tags/Angigoenesis" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Angigoenesis</span></a></p><p>Roles of <a href="https://qoto.org/tags/EndothelialCell" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>EndothelialCell</span></a> FLVCR1a, a heme exporter to extracellular space in<br>✅Developmental Angiogenesis-🐭Retina🐟ISV <br>✅Tumor angiogenesis<br>❎Vascular homeostasis</p><p>Dr. Sara Petrillo lab Angiogenesis 2023 <br><a href="https://link.springer.com/article/10.1007/s10456-023-09865-w" rel="nofollow noopener" target="_blank"><span class="invisible">https://</span><span class="ellipsis">link.springer.com/article/10.1</span><span class="invisible">007/s10456-023-09865-w</span></a></p><p>FLVCR1a deficiency-&gt; <a href="https://qoto.org/tags/EndothelialCell" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>EndothelialCell</span></a>-autonomous defects in Mitochondria, ER stress &amp; Angiogenic behaviors</p><p>Heme accumulation triggers <a href="https://qoto.org/tags/Paraptosis" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Paraptosis</span></a> (Organelle swelling-&gt; Cytoplasic vacuolation)💀</p><p>Dr. Emanuela Tolosano lab Cell Death Diff 2018 <br><a href="https://www.nature.com/articles/s41418-017-0001-7" rel="nofollow noopener" target="_blank"><span class="invisible">https://www.</span><span class="ellipsis">nature.com/articles/s41418-017</span><span class="invisible">-0001-7</span></a></p><p>Other enzymes in Heme metabolism in <a href="https://qoto.org/tags/Angiogensis" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Angiogensis</span></a>👇</p><p>Ferrochelatase is a therapeutic target for ocular neovascularization<br><a href="https://www.embopress.org/doi/full/10.15252/emmm.201606561" rel="nofollow noopener" target="_blank"><span class="invisible">https://www.</span><span class="ellipsis">embopress.org/doi/full/10.1525</span><span class="invisible">2/emmm.201606561</span></a></p><p>Serine Synthesis via PHGDH Is Essential for Heme Production in Endothelial Cells<br><a href="https://www.cell.com/cell-metabolism/fulltext/S1550-4131(18)30391-7" rel="nofollow noopener" target="_blank"><span class="invisible">https://www.</span><span class="ellipsis">cell.com/cell-metabolism/fullt</span><span class="invisible">ext/S1550-4131(18)30391-7</span></a></p>
DrSarahEJBowman<p>Hi <span class="h-card"><a href="https://mstdn.social/@DNPFred" class="u-url mention" rel="nofollow noopener" target="_blank">@<span>DNPFred</span></a></span> <br>In grad school I worked on heme proteins using <a href="https://fediscience.org/tags/paramagnetic" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>paramagnetic</span></a> <a href="https://fediscience.org/tags/NMR" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>NMR</span></a> and <a href="https://fediscience.org/tags/NRVS" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>NRVS</span></a>. Then I shifted to <a href="https://fediscience.org/tags/XRayCrystallography" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>XRayCrystallography</span></a>, using <a href="https://fediscience.org/tags/EPR" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>EPR</span></a> <a href="https://fediscience.org/tags/UVVis" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>UVVis</span></a> and <a href="https://fediscience.org/tags/EDX" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>EDX</span></a> on <a href="https://fediscience.org/tags/crystals" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>crystals</span></a> when a postdoc. My research group works on <a href="https://fediscience.org/tags/NonHemeIron" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>NonHemeIron</span></a> <a href="https://fediscience.org/tags/enzymes" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>enzymes</span></a>, &amp; <a href="https://fediscience.org/tags/heme" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>heme</span></a>, <a href="https://fediscience.org/tags/copper" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>copper</span></a> &amp; <a href="https://fediscience.org/tags/manganese" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>manganese</span></a> <a href="https://fediscience.org/tags/metalloproteins" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>metalloproteins</span></a>. Really interested in combining <a href="https://fediscience.org/tags/spectroscopy" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>spectroscopy</span></a> on <a href="https://fediscience.org/tags/protein" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>protein</span></a> <a href="https://fediscience.org/tags/crystals" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>crystals</span></a> to examine <a href="https://fediscience.org/tags/structure" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>structure</span></a> <a href="https://fediscience.org/tags/function" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>function</span></a> relationships.</p>
Thiago Carvalho<p>Serious heart damage is the most severe side effect of doxorubicin in cancer chemo, but the cause is not clear.<br>New work from Abe et al shows that</p><p>"DOX accumulated in mitochondria by intercalating into mitochondrial DNA (mtDNA), inducing ferroptosis in an mtDNA content-dependent manner. In addition, DOX disrupted heme synthesis by decreasing the abundance of 5'-aminolevulinate synthase 1 (Alas1), the rate-limiting enzyme in this process, thereby impairing iron utilization, resulting in iron overload and ferroptosis in mitochondria in cultured cardiomyocytes."</p><p><a href="https://qoto.org/tags/Chemotherapy" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>Chemotherapy</span></a> <a href="https://qoto.org/tags/doxorubicin" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>doxorubicin</span></a> <a href="https://qoto.org/tags/mitochondria" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>mitochondria</span></a> <a href="https://qoto.org/tags/heme" class="mention hashtag" rel="nofollow noopener" target="_blank">#<span>heme</span></a> </p><p><a href="https://www.science.org/doi/10.1126/scisignal.abn8017?utm_campaign=SciMag&amp;utm_source=Twitter&amp;utm_medium=ownedSocial" rel="nofollow noopener" target="_blank"><span class="invisible">https://www.</span><span class="ellipsis">science.org/doi/10.1126/scisig</span><span class="invisible">nal.abn8017?utm_campaign=SciMag&amp;utm_source=Twitter&amp;utm_medium=ownedSocial</span></a></p>